Posted by admin on Oct 1, 2014 in |
Siddha is one among the ancient systems of Indian medicine. Its reliability lies in the fact that it is time-tested, devoid of any drastic adverse effects and deep-rooted in the culture and heritage of India. The role of this system in treating chronic diseases is being widely felt nowadays. The challenges in treating such conditions with the currently available drugs (Non-Steroidal Anti-inflammatory Drugs – NSAID) often results in gastric irritation, renal damage, dependence, etc. Traditional Siddha medicines offer a wide range of Anti-inflammatory drugs which are polyherbal in nature and devoid of the above-said side-effects 1. This paper deals with Anti-inflammatory screening of such a medicine ‘Ashwathi chooranam’ documented in Classic Siddha text “Agathiar Vaithiya Kaaviyam” indicated for arthritis 2. Withania somnifera (Ashwagandha) is widely used in Siddha medicine. It is the main ingredient in many formulations prescribed for a variety of musculoskeletal conditions (e.g., arthritis, rheumatism), and as a general tonic to increase vitality, improve overall health and facilitates longevity 1. In our study, we reproduced an inflammatory...
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Posted by admin on Oct 1, 2014 in |
A series of 1-(2-(4H-1,2,4-triazol-4-yl)ethylamino)-3-ch-loro-4-(5-methoxy/ehthoxy-2-substituted alkyl/aryl-1H-indol-3-yl)azeti-dinones (4a-4h) and 1-(2-(4H-1,2,4-triazol-4-yl) ethylamino)-3-chloro-4-(5-methoxy/ethoxy-2-substituted alkyl/aryl-1H-indol-3-yl) thiazolidi-nones (5a-5h) have been synthesized by the reaction of 3-((2-(2-(4H-1,2,4-triazol-4-yl)ethyl)hydrazono)methyl)-5-methoxy/ethoxy-2-substi-tuted-1H-indoles (3a-3h) with chloroacetyl chloride and thioglycolic acid respectively. All the newly synthesized compounds were screened for their antibacterial activity against S. aureus, E. coli, P. vulgaris, K. pneumonia and antifungal activity against A. fumigatus, C. albicans, C. albicans ATCC and C. krusei G03. The antibacterial activity of newly synthesized compounds compared with standard drug gatifloxacin and ciprofloxacin against different bacteria and antifungal activity of new compounds compared with standard drug fluconazole against different fungi. The compounds 5d, 5e, 5g, and 5h exhibited good antibacterial activity while compounds 4g, 5g, and 5h also showed notable antifungal activity. The purity of the newly synthesized compounds was checked by thin-layer chromatography (TLC) on silica gel-G coated plates using different solvent systems. The structure of all the compounds was established by the elemental (C, H, N) and spectral (IR, 1HNMR, and mass)...
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Posted by admin on Oct 1, 2014 in |
Loratadine a long-acting tricyclic antihistamine with selective peripheral histamine H1-receptor antagonistic activity, is used for the symptomatic relief of allergic conditions like runny nose, itchy or watery eyes, sneezing and nasal or throat itching and chronic urticaria. It is stable in acidic pH, has a narrow therapeutic absorption window in the GI tract and found to be absorbed in the proximal part of the small intestine. Thus, it is decided to prolong the gastric residence time in terms of making floating gastro retentive drug delivery system to increase drug absorption and hence bioavailability. In this study, Loratadine floating tablets were prepared by using HPMC K15 M and Sodium Alginate as polymers and gas generating agents like sodium bicarbonate and calcium carbonate at varying polymer concentrations and combinations. The tablets prepared by direct compression technique were evaluated in terms of their pre-compression parameters and post-compression characteristics such as physical characteristics, total buoyancy, buoyancy lag time, swelling index, and in-vitro release. The best formulation showed no significant change in physical appearance,...
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Posted by admin on Oct 1, 2014 in |
Cosmetic applications of spices and herbs are well recognized. Apart from preservative and antimicrobial activities, spices display copious antioxidant activity. Inclusion of these antioxidants in topical supplements has proved to be effective against oxidative aging. However, food and contact allergy to most spices make it mandatory to screen for skin and eye irritation activities before cosmetic applications. In this report, we have aimed to compare ethanolic extracts of five seeds belonging to family Apiaceae (C. carvi, C. cyminum, C. sativum, T. ammi, A. graveolens) concerning their antioxidant activities, phenol and flavonoid content, in-vitro cytotoxicity, and eye irritation tests. Our investigation illustrates that C. carvi expresses the highest antioxidant activity among these. Further, the polyphenol content and antioxidant activity are positively correlated in all samples. In-vitro cytotoxic analysis on chick embryo fibroblasts and in-vitro eye irritation assays demonstrate 200µg/ml concentration of these extracts can be safely used for cosmetic...
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Posted by admin on Oct 1, 2014 in |
Objective: Modulation of the immune responses to alleviate the diseases has been of interest for many years. Thus, a real need exists to protect our immune systems and lead healthier lives. Hence the present study is aimed to evaluate the immunomodulatory activity of the Flavonoid of Kigelia africana (Family: Bignoniaceae). Methods: The assessment of immunomodulatory activity on cell-mediated and humoral mediated immunity were studied by Carbon clearance test; Cyclophosphamide induced neutropenia, Indirect Haemagglutination reaction, Neutrophil adhesion test, and effect on Serum immunoglobulin level. Results: Flavonoid of Kigelia africana was administered orally at a low dose and a high dose of 100mg/kg/day, po and 200 mg/kg/day, po respectively and Levamisole (2.5 mg/kg/day, po) was used as standard drug. Flavonoid of Kigelia africana in both doses showed a significant increase in the phagocytic index in carbon clearance assay, significant protection against Cyclophosphamide induced neutropenia. It also increased the circulating antibody titer in an indirect haemagglutination test and increased the adhesion of neutrophils in the neutrophil adhesion test. Hence, it was concluded...
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