Posted by admin on Sep 1, 2014 in |
Several formulations are marketed globally, claiming to be useful in diabetes & other associated diseases. In the present study, an attempt has been made to study the comparative efficiency of herbal formulations, for their hypoglycemic activity. The study was conducted on healthy rats randomly distributed streptozotocin (STZ) induced diabetic control & test rat groups. In diabetes-induced rats fed with herbomineral formulation 500 mg/kg & 1000 mg/kg. The hypoglycemic activity was studied by measuring the reduction in blood glucose levels & increased body weight at different time intervals. The present investigation was undertaken to evaluate the Antidiabetic activity of herbomineral formulation containing five different herbs & two minerals in streptozotocin (STZ 50 mg/kg ip single dose) induced diabetic rats. Treatment with formulation F1 (500 mg/kg) & F2 (1000 mg/kg) by oral administration for 4 weeks produced a significant reduction in blood glucose level & increase body weight in diabetic rats. The efficacy of plant extract was comparable with Glibenclamide & Insulin, a well known hypoglycemic drug. In STZ induced diabetic...
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Posted by admin on Sep 1, 2014 in |
A novel series of transition metal complexes of [M(C19H18N2O2S)X2], where M = Ni(II), Cu(II), X = Cl–, NO3–, ½ SO42- and (C19H18N2O2S) moiety corresponds to the tetradentate aza-oxo macrocyclic species, were synthesized by template condensation reaction of 1,4-bis(2-formylphenoxy)butane and thiourea in the presence of divalent metal salts in 1:1:1 ratio. The metal complexes were characterized and analyzed by elemental analyses, molar conductance, magnetic measurements, and spectral techniques like IR, mass, UV-VIS, electron paramagnetic resonance spectroscopy, and thermal studies. The low values of the molar conductance values indicate the non-electrolytic nature of synthesized complexes except nitrato complex of Ni (II) which is 1:2 electrolytic in nature. Based on aforesaid spectral studies, [Cu(C19H18N2O2S)(SO4)] complex may possess trigonal bipyramidal geometry, [Ni(C19H18N2O2S)](NO3)2 complex tetrahedral geometry and rest of the complexes six coordinated octahedral/tetragonal geometry. To explore the complexes in the biological field, synthesized transition metal complexes were examined against the pathogens A. niger, S. rolfsii, F. oxysporum, and A. brassicae. All metal complexes displayed good antifungal...
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Posted by admin on Sep 1, 2014 in |
The present study was aimed to investigate the methanolic (MEMP), ethyl acetate (EEMP) and n-hexane (HEMP) extracts of the whole plant of Mucuna pruriens for their in-vitro Antiurolithiatic potential. Calcium oxalate crystallization was induced by the addition of 0.01M sodium oxalate solutions in synthetic urine. The in-vitro anti-urolithiatic activity of various extracts of M. pruriens was investigated by measuring the turbidity of various concentrations of (50µg m/ml, 100µg m/ml, 150µg m/ml, 200µg m/ml, and 250µg m/ml) each extract in synthetic urine, by using UV/Visible spectrophotometer at 620 nm after incubating them for 10 min and microscopically under microscope equipped with digital camera at 10X. The results of the present study showed that the MEMP, EEMP dose-dependently inhibited the formation of calcium oxalate (CaOx) crystallization in the synthetic urine which was evident from the spectroscopic as well as in the microscopical studies. It was concluded that the antiurolithiatic activity of Mucuna pruriens was possibly mediated through inhibition CaOX crystals in the synthetic urine. But, further, in-vivo, preclinical studies are required...
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Posted by admin on Sep 1, 2014 in |
Objective: To study the nephroprotective activity of Bauhinia purpurea unripe pods and bark against gentamicin-induced nephrotoxicity. Materials and Methods: Twenty four healthy adult albino rats of either sex (150-200 g) were randomly divided into four groups of six animals each. Group, I served as vehicle control and Group II as the negative control (gentamicin 80 mg/kg/d, i.p). Groups III and IV (test groups) were administered ethanolic extract of Bauhinia purpurea bark (BBE) and unripe pods (BPE) in the dose of 400 mg/kg/day, one hour before gentamicin administration. All the treatments were given for 8 days. On the 9th day, blood and urine samples were used for biochemical analysis and kidneys for histology and assessing anti-oxidant activity. Results: Gentamicin caused nephrotoxicity as evidenced by highly significant (p<0.001) elevation of blood urea, serum creatinine and urine glucose in Group II as compared to Group I. Also administration of Gentamicin in group II caused oxidative stress in rats suggested by significant increase in MDA level and significant decrease in Catalase and Reduced...
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Posted by admin on Sep 1, 2014 in |
The kinetics of oxidation of quinine sulphate [8α, 9R-61– methoxycinchonan- 9 – ol sulphate], (QS) by Chloramine-B (Sodium N-Chlorobenzene Sulphonamide, CAB) has been studied in aqueous hydrochloric acid medium at 303 K. The reaction rate shows a first order with respect to [CAB], fractional order with respect to [HCl] and [QS]. Activation parameters were evaluated from the kinetic data at different temperatures. Negative entropy of activation indicated the involvement of a rigid complex in the activated state. The dielectric constant of the medium has a small effect on the rate. Ionic strength and the reduction product benzene sulphonamide [BSA] do not affect the reaction rate. The solvent isotope effect is studied. The reaction products are identified and characterized by spectral (IR and NMR) data. The proposed reaction mechanism and the derived rate equation are consistent with the observed kinetic...
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