Posted by admin on May 1, 2014 in |
Oxidative stress is found to be one of the major causes of health hazards in the present global scenario. The traditional herbs and medicinal plants have been investigated for the presence of natural antioxidants, which have incredible effects in the prevention of various oxidative stress associated diseases. The objective of present investigation is to assess the antioxidant capacity and phytochemical analysis of selected endemic medicinal plants viz., Abutilon indicum, Albezia odoratissima, Aglaia elaegnoides, Calicarpa tomentosa, Colebrookia oppostifolia and Pterocarpus marsupium. The antioxidant potentiality of these medicinal plants was assayed by 1,1-Diphenyl-2-picryl hydrazyl (DPPH), hydroxyl, superoxide radical scavenging and lipid peroxidation assays, total antioxidant potential by Ferric reducing antioxidant power (FRAP) assay. Qualitative phytochemical analysis revealed that ethanolic bark extract of A. odoratissima showed positive results for the presence of alkaloids, phenols, flavonoids, tannins, anthraquinones and saponins. The plants with high phenol contents showed high antioxidant activity. The results showed that ethanolic bark extract of A. odoratissima exhibited highest antioxidant activity by possessing considerably high...
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Posted by admin on May 1, 2014 in |
Human immunodeficiency virus (HIV) is a lent virus that cause acquired immunodeficiency syndrome (AIDS), a state in humans in which progressive failure of the immune system allows life-threatening opportunistic infections and cancers to thrive. HIV-1 protease is a retroviral aspartyl protease (retropepsin) that is essential for the life-cycle of HIV, the retrovirus that causes AIDS. HIV Wild type (PDB: 3EKV) and Mutated (PDB: 3NU9) proteins structures were retrieved from Protein Data Bank in order to check the consistency of ligand’s interactions even if mutated viral attack is present. Docking is frequently used to predict the binding orientation of small moleculedrug candidates to their protein targets in order to in turn predict the affinity and activity of the small molecule. Docking study of the target protein was done with natural compounds derived from Annona Squamosa to find the preferred orientation and binding affinity of drug with target protein using scoring functions. Annona squamosa is a small, well-branched tree or shrub from the family Annonaceae that bears edible fruits called sugar-apples....
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Posted by admin on May 1, 2014 in |
The present study is done to study and optimize the process of enzyme-assisted extraction of Chebulinic acid from the dried fruit of Terminalia chebula. A selective extraction process after the treatment with enzymes is proposed by using 30% (v/v) methanol which releases increased yield of the Chebulinic acid, present in the dried fruit compare to aqueous extract. The optimal conditions were as follows: pH value was 4.5, concentration of cellulase solution was 2.5 mg/mL, incubation time was 8 h, and incubation temperature was 50 º C and solid: solvent ratio was 1:8.Enzymes have the ability to degrade or disrupt cell walls and membranes, thus enabling better release and more efficient extraction of bioactives. Enzyme-assisted extraction methods are gaining more attention because of the need for eco-friendly extraction technologies. Enzyme-assisted extraction was proven to be highly efficient in the designing, process development and standardization of extraction of marker compound from herbal drugs and could be used in making enriched phytopharmaceuticals which may be translated into herbal drug for treating a...
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Posted by admin on May 1, 2014 in |
Hair fall is a very common phenomenon and a matter of concern within whatever young or aged. This study is formulated a herbal hair oil and made a clinical trial over selected person under the research and development unit at Routi Herbal Limited. To see the efficacy of the experimental oil made up of Kala Jera Toil (Nigella sativa) Narkal Toil (Cocos nucifera) Amloki (Emblica officinalis) Henna ( Lawsonia alba) Durba Ghas ( Cynodon dactylon) Mathi (Trigonella foenum-graecum) in different concentration over the simple Coconut Oil (purified). Total 90 volunteers man and women were selected for 90 days and arranged in 3 groups, one for experimental oil recipient, one for control group another for the simple Coconut Oil (purified) recipient. And it is found that hair fall reduced to 76%, 72%, 67%, 59%, 32%, 0% on 15days, 30 days, 45 days, 60 days, 75 days, and 90 days by using of this experimental herbal hair oil. Aims of the study: To find out the efficacy of test herbal hair...
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Posted by admin on Apr 6, 2014 in |
The present study was carried out to investigate the diuretic activity of the ethanolic extract of Teucrium polium L. Capitatum (Lamiaceae)in normal albino rats. The diuretic activity of extract was evaluated by determining the urine volume and electrolyte concentration in albino rats (n=4). Furosemide (20 mg/kg) was used as the reference diuretic drug while normal saline (0.9%) was used as control. Alcoholic extract of the drug (25 mg/kg and 50mg/kg) were used as tests. Urine output and electrolytes (Na+, K+ and Cl−) excretion were estimated at the end of 8 hours. Ethanolic eextract has significantly increased the volume of urine (6.70±0.09ml/100g/8hr and 8.40 ±0.46ml/100gm/8hr), and has also increased the diuretic index to 1.09 and 1.37 for 25mg/kg and 50mg/kg dose ranges respectively (P< 0.01). The test drug, when compared to the control group, displayed a significant increase in the excretion of potassium and chloride. There was an increase in the saluretic index as reflected by the Na+/K+ ratio to 5.03 and 5.44 respectively for the two dosages studied when...
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