Posted by admin on Jun 1, 2014 in |
The present study is aimed to elucidate the antioxidant property and anti-inflammatory activity of hydro-ethanolic extract of Ganoderma lucidum (HEGL)known to possess medicinal activity against numerous diseases. The chemical composition of HEGL was quantified by colorimeteric technique in terms of total phenol and flavonoid content. Antioxidant activity was determined by 2,2’-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) diammonium salt (ABTS), 2,2-diphenyl-1-picryl-hydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays. The extract possesses strong anti-oxidant property in terms of high content of phenols, flavonoids and reducing power. Coumarin a known antioxidant and anticoagulant compound was identified and quantified by HPLC. Further, a dose dependent in vitro study for HEGL extract was carried out to observe anti-inflammatory activity in THP1 cells. HEGL extract significantly suppressed lipopolysacharide (LPS) – induced release of TNF-α, IFN-g and IL-1β in THP1 cells and significantly suppressed nitric oxide (NO) release in macrophages cells without causing any toxic effect. Additionally, HEGL extract also decreased NF-kB expression in LPS-treated cells indicating anti-inflammatory activity of hydro-ethanolic extract of Ganoderma lucidum (HEGL) at the...
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Posted by admin on Jun 1, 2014 in |
A new series of transition metal complexes of the type ML where M = Cu(II), Co(III) and Fe(III) and L = 2-benzoyl-3-(nitrophenyl)quinoxaline have been characterized and the structural features were arrived from the elemental analysis, magnetic susceptibility, molar conductance, FT- IR, UV-Vis and NMR spectral data. From the spectral measurements and magnetic susceptibility values a square planar geometry was proposed for Cu(II) complex and an octahedral geometry for Co(III) and Fe(III) complexes. The qualitative and quantitative antimicrobial activity test results proved that all the prepared complexes are very active especially against E. coli, S. aureus, C. albicans and A....
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Posted by admin on Jun 1, 2014 in |
The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome by the use of in situ gel-forming systems that are instilled as drops into the eye and undergo a sol–gel transition in the cul-de-sac. Norfloxacin ophthalmic solution has been shown to be effective ocular infections and may be used in patients with chronic conjunctivitis or ocular irritation. Norfloxacin in-situ gel was prepared using various concentrations of polymers such as Carbopol-934 and HPMC K4M by pH triggered gelling system with objectives of increasing contact time, achieving controlled release, reduction in frequency of administration and greater therapeutic efficacy of drug. The prepared in-situ gels were then evaluated for their visual appearance, clarity, pH, drug content analysis, in-vitro gelation (Gelling capacity), rheological studies, sterility testing and in-vitro drug release studies. It is evident from these studies that, formed polymeric in-situ gels had transparent, clear possessing satisfactory gelling capacity. The developed formulation was light yellow in colour, therapeutically efficacious, stable, non-irritant...
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Posted by admin on Jun 1, 2014 in |
The present study was carried out to investigate the effects of oral administration of aqueous extracts of Cleome rutidosperma leavesand Senecio biafrae roots on blood glucose, biochemical parameters, lipid profile, antioxidant enzymes activity and hepatic glucose regulating enzyme activities in Streptozotocin (STZ)-induced diabetic rats. STZ was administered as a single dose (60mg/kg wt, i.p.) to induce diabetes. The effects of the extracts were compared with the standard drug Glibenclamide (600μg/kg b.wt). The aqueous extract of both plants at different doses (125mg/Kg, 250mg/Kg and 500mg/Kg) administered orally to the diabetic rats for 28 days, produced significant (p < 0.05) decrease in the level of blood glucose, feed and water intake as well as serum cholesterol, triacylglycerols, low density lipoprotein (LDL), creatinine, urea, bilirubin and activity of liver marker enzymes such as AST, ALT, ALP and TBARS in liver and kidney. Treatment also produced significant (p < 0.05) increase in body weight, PCV, High density lipoprotein (HDL), Superoxide dismutase (SOD), Catalase (CAT), Glutathione-S-Transferase (GST) and Glutathione Reductase(GR). Administration of both extracts...
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Posted by admin on Jun 1, 2014 in |
Background: Health care professionals, patients, public, patient caretakers, and other professionals prefer to ask their medication-related questions to community pharmacists as they are easily accessible to them. It is challenging for pharmacists to keep up the pace of medicine discovery and development and have better and effective information than the patients retrieve information independently. Aim and objectives: The aim of this study was to identify information resources of medicine used by the community pharmacists in various parts of Oman to update the knowledge and provide updated and effective information to the patient and other medical professionals. Other objectives of this study were to know the most common primary, secondary, tertiary, web based and other information resources used by the community pharmacists. Methods: Total of 71 community pharmacies in different parts of Oman were contacted personally. Pharmacists at the sample community pharmacies completed a self-administered questionnaire that consisted of six sections. First section presented demography of population for the study. Second section elicited type of sources of information the community...
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