Posted by admin on Apr 1, 2014 in |
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. The aim of the present research work was to develop sustained release multi-layered formulation of Methotrexate, targeted to colon by using the combination of pH- dependent release, timed release and microbially triggered system. Multi-layered tablets were prepared by wet granulation technique method using starch paste as binder. Prepared formulations were subjected to various studies like hardness, friability, thickness, % drug content, weight variation etc. The influence of core tablet compositions, polymer combination ratios and coating levels on the in vitro release rate of Methotrexate from coated tablets was investigated. The results showed that less than 10% drug was released within %hrs (0.1 N HCl for2 hr and phosphate buffer pH 7.4 for 3hrs), and about 40% of the drug was released in...
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Posted by admin on Apr 1, 2014 in |
In this paper, an attempt was made to develop a Group-Quantitative Structure Activity Relationship (GQSAR) model on a series of substituted Quinoline derivatives as anti-Tubercular agents. The dataset was fragmented based on substitution points on the quinolone ring. Various 2D descriptors were calculated and used in the present analysis. For model validation, the dataset was divided into various training and test sets using sphere exclusion method. The developed G-QSAR models were found to be statistically significant with respect to training (r2>0.7), cross-validation (q2>0.6), and external validation (pred_r2>0.5). The developed GQSAR model suggests that substitutions on fragment R4 have an important role in determining biological...
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Posted by admin on Apr 1, 2014 in |
ABSTRACT: The main objective of the study is to promote awareness and assess the knowledge of adolescents on medication use, importance of balanced diet and physical activity. The study was conducted among the adolescents’ aged from16-18 years in regions of Guntur. The volunteers are allowed to fill their informed consent to be a part of the study. The questionnaire was distributed to all the volunteers included in the study, which includes questions on their medication taking behaviour, dietary habits and physical activity. The response was then analysed to assess the knowledge on medication use, balanced diet and physical activity. Among the 165 individuals on assessment of their medication taking behaviour 78% of them do not follow their prescription, 61% of the individuals do not have any idea on their medication use and a majority of 74% are not aware of the unwanted effects caused by the medication. On assessment of their dietary habits and physical activity, 62% of the individuals include meal rich in fat, 42% of the individuals...
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Posted by admin on Apr 1, 2014 in |
The present investigation concerns the design and evaluation of floating tablets of Tizanidine hydrochloride, which after oral administration are designed to prolong the gastric residence time and increased drug bioavailability. It is a centrally acting α2 adrenergic agonist. It is used in the treatment of migraine headaches, spasms and anticonvulsant. The dosage was designed by using natural polymers, Guar gum, Xanthan gum, Karaya gum, Psyllium and HPMC. Floating tablets prepared by direct compression technique. The prepared floating tablets were evaluated in terms of their precompression parameters, friability, hardness, uniformity of weight, drug content, swelling index, in-vitro dissolution studies. The floating properties and drug release studies were determined using 0.1N HCl as a dissolution medium. The best formulation was determined based on the buoyancy and drug release...
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Posted by admin on Apr 1, 2014 in |
Organ weight analysis is an important endpoint for identification of potentially harmful effects of test compounds in toxicology studies. Organ weight differences are often accompanied by differences in body weights between treatment groups which make the organ weight interpretation more difficult. We have evaluated the relationship between organ weight and body/brain weight based on statistical analysis to determine which endpoint (absolute organ weight, organ-to-body weight ratio, or organ-to-brain weight ratio) is likely to accurately detect target organ toxicity by using data from control rats that were part of 43 toxicity studies conducted under similar conditions. All the organs weight data of both sexes were subjected to the linear regression; correlation was established with body weight and brain weight. Present data set revealed that there was a strong correlation between liver, kidneys and heart weights with body weights. Organs like spleen and adrenal weight also showed correlation with body weight. Other commonly weighed organs in toxicity studies viz. thymus, pituitary and thyroid- parathyroid did not show consistent pattern of relationship...
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