Posted by admin on May 1, 2014 in |
Mucoadhesive buccal patches containing diclofenac sodium were prepared using the solvent casting method. HPMC used as bioadhesive polymer and different ratio of propylene glycol and glycerin also used. FT-IR and UV spectroscopic methods revealed that there is no interaction between Diclofenac sodium and polymers. The patches were evaluated for their physical characteristics like mass variation, drug content uniformity, folding endurance, surface pH, and in vitro drug release, in vitro buccal permeation study. Incorporation of DMSO generally enhanced the release rate. Swelling index was proportional to the concentration of HPMC. Optimized patches (F) showed satisfactory bioadhesive strength. The surface pH of all batches was within ± 0.4 units and thus no mucosal irritation is expected. Patches containing of F5 had higher bioadhesive strength with sustained drug release as compared to patches with other ratios of polymer. Data of in-vitro release from patches were fit in to different equations and kinetic models to explain release kinetics. The models used were zero and first-order, Hixon-Crowell, Higuchi and Korsemeyer-Peppas models equation. The optimized...
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Posted by admin on May 1, 2014 in |
Back ground: The study was designed to determine antiadipogenesis properties of crude methanolic extracts from four species of Caralluma R.Br. such as Caralluma adscendens (Roxb.) R. Brown var. attenuata (Wight) Grav. & Mayur. (CAA), Caralluma adscendens (Roxb.) R. Brown var. fimbriata (Wall.) Gravely & Mayur. (CAF), Caralluma stalagmifera C.E.C. Fisch. (CS) and Caralluma stalagmifera C.E.C. Fisch. var. longipetala Karupp. & Pull. (CSL) and as well as two species of Boucerosia Wight & Arn. such as Boucerosia lasiantha Wight.(BL) and Boucerosia umbellata (Haw.) Wight & Arn. (BU) at intervarietal and interspecific levels along with bioactivity studies. (BU) along with an isolated compound pregnane steroid using different cell lines. Methods: In vitro inhibitory activity of adipogenesis and facilitating activity on adipolysis were evaluated in 3T3 L1 adipocytes. Results: The percentage anti adipogenesis (50 µg/ml ) was also observed with values of 15.29%, 4.20%, 12.27%, 21.85%, 0 and 9.75% respectively. The percentage inhibition of pregnane steroid in adipogenesis of 3T3 L1 preadipocytes by 1 and 5 µg/ml were 21.22% and 35.97% respectively. Discussion: Four of...
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Posted by admin on May 1, 2014 in |
The study was designed to determine the phytocomponents and in-vitro anthelmintic activity of chloroform fraction of methanolic extract of Antigonon leptopus leaves. GC-MS analysis of chloroform fraction of the methanolic extract of Antigonon leptopuswas performed on a GC–MS equipment (Thermo Scientific Co. Thermo GC-TRACE ultra ver.: 5.0, Thermo MS DSQ II). The extract under study has been screened for anthelmintic activity on Pheretima posthuma. The chloroform fraction was analysed by GC-MS which revealed the presence of many diversified compounds including phenols, hydrocarbons, quinazolines, coumarins, steroids and terpenes like cadinene, juniper camphor etc. All the compounds were identified from Wiley spectral library. Mass spectral data of 16 compounds is presented. The results obtained from the study indicate significant anthelmintic activity, supporting folk use of the plant when compared with the standard. From the results, it is evident that Antigonon leptopus contains various bioactive compounds and biological activity which is recommended as a plant of phytopharmaceutical...
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Posted by admin on May 1, 2014 in |
Some transitional metal ions complexes with 3-{[(Z)-(4-hydroxyphenyl) methylidene] amino} benzoic acid with general formula [M(L2)xH2O], [where M = Mn(II),Co(II), Ni(II),Cu(II), Zn(II), Pd(II) and Pt(II)metal ions and L=3-{[(E)-(4-fluorophenyl) methylidene] amino} benzoic acid ] have been synthesized and characterized on the basis of elemental analysis, conductance, magnetic susceptibility, IR, UV-Visible, ESR, X-RD and TGA/DTA. The complexes are covalent in nature with octahedral geometry. The covalency factor (β), bonding parameter were calculated. The dentistry of the complexes was in the range between 1.5 to 1.90 m/dm3 in toluene and the spectral line indicates low crystallinityof the complexes. All the complexes are non-electrolytic in nature. All the complexes are paramagnetic in nature expect Zn(II) complexes indicates slight participation of the 3d electron in bond formation. The ligand and its complexes have been screened for their antimicrobial activity with some bacteria it shows that antibacterial and antifungal activity complexes are more active towards these bacteria than Schiff...
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Posted by admin on May 1, 2014 in |
Hypoglycaemic and anti-hyperglycaemic effects of Portulaca oleracea Linn. (POL) was evaluated in experimental rat models in vivo. The aqueous extract of POL was subjected to preliminary toxicity screening by an acute toxicity study in Wister albino rats. The POL was found to be safe in the doses used and there was no mortality up to a dose of 3000mg/kg orally after 24 hours. Hypoglycaemic effects of POL extract with doses 200mg, 400mg and 800mg were evaluated on Wistar albino rats by using a standard protocol. Anti-hyperglycaemic effect of POL extract with the same doses i.e. 200mg, 400mg and 800 mg were also studied in alloxan induced diabetic albino rats. The aqueous POL extract at doses 800mg showed significant hypoglycaemic effects as compared with a standard drug like glibenclamide. The same doses of POL also showed anti-hyperglycaemic properties in alloxan induced diabetic rats. The present study showed that the aqueous POL extract has hypoglycaemic as well as anti-hyperglycaemic...
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