Posted by admin on Jun 1, 2014 in |
This work aimed to formulate amlodipine besylate Oro flash release films by solvent casting method. Various film forming polymers like Hydroxy propyl methyl cellulose (HPMC) E5, HPMC E15, sodium carboxymethyl cellulose, sodium alginate, xanthan gum were used and out of which HPMCE5 was found to be satisfactory. Propylene glycol was used as plasticizer at a range of 13-32%w/w of the film and 31%w/w was found to be the best concentration based on the flexibility and the strength of the film. Optimized formulation contains HPMC E5 as a film forming agent, propylene glycol as a plasticizer, tween 80 as a surfactant, peppermint oil as flavoring agent and aspartame as sweetening agent. Films were prepared by solvent casting method and found to satisfy the mouth dissolving time and other film parameters. 1.5 x 1.5 cm of film is required to be placed on to patient tongue which gets wet by saliva, rapidly hydrates, adheres to tongue and rapidly disintegrates and dissolves to release the drug for the oro – mucosal absorption...
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Posted by admin on Jun 1, 2014 in |
A protocol was devised for callus induction and in vitro micro propagation of Anisochilus carnosus. Leaf, nodal and immature inflorescence explants were cultured for callusing on solid MS medium with best callusing response achieved at higher concentrations of BAP (12mg/l) alone and in combination with 2,4-D (3mg/l) and IAA (5mg/l). Bud regeneration from inflorescence callus giving maximum (9.67±0.58) shoots per bud was achieved at 12mg/l BAP+5mg/l IAA. Elongated shoots were transferred to half strength MS liquid medium for in vitro rhizogenesis, with best rooting achieved in 2mg/l IBA giving maximum number of 13.00±1.00 roots per shoot. The rooted plantlets were hardened by transferring to polycups containing sterile soil and vermicompost in the ratio of 1:1. After 15 days of hardening, established plantlets were transferred to field with maximum...
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Posted by admin on Jun 1, 2014 in |
For more than a century Peptic Ulcer Disease (PUD) has been considered to be a major cause of morbidity and mortality. Most first line treatment for PUD involves use of acid suppressing drugs and target against the eradication of Helicobacter pylori (H. pylori) infection. However, the treatment strategy employed in India is not well studied. Hence, this study aims to provide insight into the prescription pattern of drugs used in PUD in India. The data was extracted from the medical records of all patients diagnosed with PUD from June 2011 to May 2012. A retrospective analysis was done to study the prescribing pattern of the drugs. The data was noted down on a pre-designed proforma and analysed. Records of 200 patients were assessed. About 91% of patients were prescribed anti H. pylori kit and the most commonly prescribed kit being Esomeprazole H.P kit (59.7%) followed by Pantoprazole H P kit. Following this, all patients were started on Proton pump inhibitors (PPI) for duration of about 6.89±2.25 weeks. On the...
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Posted by admin on Jun 1, 2014 in |
We studied 90 patients undergoing elective as well as emergency caesarean section under spinal anaesthesia who developed hypotension after subarachnoid block (SAB). They were randomly divided in three groups: Group P Phenylephrine 100µg (n=30), Group E Ephedrine 6mg (n=30) or Group M Mephentermine 6mg (n=30) as IV bolus. Hypotension was defined as decrease in systolic arterial pressure > 20% of baseline values. Elevation of systolic arterial pressure in group P was significantly high for first 6 min of bolus dose as compared to group E and M. There was significant reduction in heart rate in group P. Neonatal Apgar score was >7 in all three...
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Posted by admin on Jun 1, 2014 in |
Acne vulgaris is a most common skin disorder of pilosebaceous unit that affect areas containing the largest oil glands, including the face, back, and trunk. It is generally characterized by formation of seborrhea, comedone, inflammatory lesions. Propionibacterium acnes and Staphylococcus epidermidis have been recognized as pus-forming bacteria triggering an inflammation in acne. Staphylococcus aureus support to cause inflammation in acne. The present research work deals with formulation and evaluation of herbal gels against this etiologic agent of acne vulgaris. The ethanolic extract of Neem (leaves), Nutmeg (fruit), and Black pepper (fruit) were prepared and formulated into a topical gel. In vitro antibacterial activity was performed against P. acnes, S. epidermidis and S. aureus, using agar well diffusion method. The measured zones of inhibitions of the prepared formulations were compared with standard antibiotic (Clindamycin) and standard marketed topical herbal formulation. The prepared gels were evaluated for pH, viscosity, spreadability, stability, drug content, acute skin irritancy activity and in vitro diffusion. The results from the agar well diffusion showed that Neem,...
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