Posted by admin on May 1, 2014 in |
Hair fall is a very common phenomenon and a matter of concern within whatever young or aged. This study is formulated a herbal hair oil and made a clinical trial over selected person under the research and development unit at Routi Herbal Limited. To see the efficacy of the experimental oil made up of Kala Jera Toil (Nigella sativa) Narkal Toil (Cocos nucifera) Amloki (Emblica officinalis) Henna ( Lawsonia alba) Durba Ghas ( Cynodon dactylon) Mathi (Trigonella foenum-graecum) in different concentration over the simple Coconut Oil (purified). Total 90 volunteers man and women were selected for 90 days and arranged in 3 groups, one for experimental oil recipient, one for control group another for the simple Coconut Oil (purified) recipient. And it is found that hair fall reduced to 76%, 72%, 67%, 59%, 32%, 0% on 15days, 30 days, 45 days, 60 days, 75 days, and 90 days by using of this experimental herbal hair oil. Aims of the study: To find out the efficacy of test herbal hair...
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Posted by admin on Apr 6, 2014 in |
The present study was carried out to investigate the diuretic activity of the ethanolic extract of Teucrium polium L. Capitatum (Lamiaceae)in normal albino rats. The diuretic activity of extract was evaluated by determining the urine volume and electrolyte concentration in albino rats (n=4). Furosemide (20 mg/kg) was used as the reference diuretic drug while normal saline (0.9%) was used as control. Alcoholic extract of the drug (25 mg/kg and 50mg/kg) were used as tests. Urine output and electrolytes (Na+, K+ and Cl−) excretion were estimated at the end of 8 hours. Ethanolic eextract has significantly increased the volume of urine (6.70±0.09ml/100g/8hr and 8.40 ±0.46ml/100gm/8hr), and has also increased the diuretic index to 1.09 and 1.37 for 25mg/kg and 50mg/kg dose ranges respectively (P< 0.01). The test drug, when compared to the control group, displayed a significant increase in the excretion of potassium and chloride. There was an increase in the saluretic index as reflected by the Na+/K+ ratio to 5.03 and 5.44 respectively for the two dosages studied when...
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Posted by admin on Apr 1, 2014 in |
Diabetes mellitus basically a chronic metabolic disorder that results in boosting up blood glucose level to higher concentrations. It is associated with bunch of diseases. To overcome patient’s common problems i.e. throat pain, vomiting, non-compliance, inconvenience and ineffective therapy plan or to enhance patient compliance and effectiveness of therapy scientists have launched orodispersible tablets to attract patients for improving their quality of life. Methods of preparation along with superdisintegrants are the major players in the success of this dosage form. In the present work, antidiabetic orodispersible tablets (ODT’s) containing drugs (Metformin HCl and Glibenclamide) and superdisintegrants (pregelatinize starch and sodium starch glyconate) were prepared by three different techniques i.e. direct compression, effervescent method and sublimation technology. Fifteen formulations (F1-F15) were prepared by using these techniques. Pre-compression studies including rheological analysis (Bulk density, Tapped density, Angle of repose, Carr’s compressibility index, Hausner’s ratio) and compatibility studies such as Differential Scanning Calorimetry (DSC) and Fourier Transform Infrared spectroscopy (FTIR) were performed. Post compression studies on various parameters i.e. tablet hardness, weight...
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Posted by admin on Apr 1, 2014 in |
To evaluate phytochemical constituents and antioxidant potential of aqueous and hydroalcoholic extracts of root of Mentha arvensis L from Kashmir region. The antioxidant activity of aqueous and hydroalcoholic extracts of Mentha arvensis L was evaluated by using 1, 1-diphenyl, 2-picrylhydrazyl (DPPH) scavenging, reducing power, metal chelating, hydrogen peroxide scavenging and nitrous oxide scavenging assays. The total phenolic content (mg/g) was found to be 9.12 and 211.11 mg/g in aqueous and hydroalcoholic extracts respectively and total flavonoid content (mg/g) was found to be 32.14and 230.18 mg/g in aqueous and hydroalcoholic extracts respectively. The percentage inhibition values of DPPH scavenging for aqueous and hydroalcoholic extracts was found to be 35.83 and 57.63 respectively. The percentage inhibition values of Nitrous oxide scavenging for aqueous and hydroalcoholic extracts was found to be 39.11 and 63.25 respectively. The percentage inhibition values of H2O2 scavenging for aqueous and hydroalcoholic extracts was found to be 21.72 and 39.66 respectively. The percentage inhibition values of metal chelating activity for aqueous and hydroalcoholic extracts was found to be...
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Posted by admin on Apr 1, 2014 in |
A new Reversed Phase-High Performance Liquid Chromatographic method was developed and validated for the quantitation of Cefpodoxime proxetil (Cef) and Potassium clavulanate (Pot. clav.) in pharmaceutical formulations. Determination was performed using a Hypersil-BDS (C-18) column (5 μm, 250 mm 4.60 mm), a mobile phase containing phosphate buffer (5.5 pH): acetonitrile (51:49 v/v), in isocratic flow rate 1 mL/min. with UV detection at 233.0 nm. The retention time (tR) for Cef and Pot. clav. were 5.63 min. and 2.49 min. respectively. Linear relationships were obtained between response and amount of drug with high correlation coefficients (r2) in the range 1-60 µg mL-1 for Cef (r2 = 0.9966 ) and 0.5-60 µg mL-1 for Pot. clav. (r2 = 0.9954). The method was validated for precision, accuracy and robustness as per ICH guidelines. Inter- and intraday relative standard deviation values for Cef were 0.801% and 0.692% respectively and 0.905% and 1.042% for Pot. clav. respectively. Total recoveries of Cefand Pot. clav. from the tablet formulation were 99.71% and 99.51% respectively. The specificity of the method...
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