Posted by admin on Apr 1, 2014 in |
Niosomes, an emerging class of novel vesicular systems, are non-ionic surfactant vesicles which can entrap both hydrophilic and lipophilic drugs. Niosomes are incorporated into in situ gels for sustained release of drug and to prolong the residence time. The aim of present study is to formulate and evaluate ocular niosomal in situ gels of Linezolid. Linezolid is a potent synthetic oxazolidinone derivative active against a broad range of gram positive and gram-negative aerobic and anaerobic bacteria. Niosomes were prepared using various surfactants (span 20, span 40, span 60 and span 80) in different ratios using thin film hydration technique. They were evaluated for particle size, entrapment efficiency and in vitro drug release. Niosomes prepared using cholesterol and span 60 in the ratio 1:2 showed higher entrapment efficiency and better in vitro drug release. The optimized formulation was formulated as in situ gels using Carbopol 971P and HPMC K4M in different ratios and evaluated for gelling capacity, pH, viscosity, in vitro drug release, drug content, antimicrobial activity and ocular irritation...
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Posted by admin on Apr 1, 2014 in |
Cutaneous leishmaniasis (CL) is a public health problem in Syria call for this parasite’s epidemiological and evolutionary investigation. Evaluation of its population structure by multilocus enzyme electrophoresis (MLEE), current gold standard for classification, has some drawbacks ,such as the lack of discriminatory power below species level, it is labour intensive and time-consuming. In this study , MLEE has been replaced by applying PCR-RFLP of the internal transcribed spacer 1 (ITS1) for identification of leishmania at species level, on 37 samples were obtained from patients with suspected CL referred to Damascus Dermatology Hospital, 19 of them from Damascus and 18 from Aleppo. Intraspecific variation could be detected by the use of 9 hypervariable microsatellite markers. Our results showed that all samples were L. tropica. 26 genotype were detected, of wich 20 were unique to individual strains and 6 were shared by more than sample. Results also showed that there was amoderate genetic differentiation and a clear genetic flow between Aleppo and Damascus. In conclusion, in the present study, the first...
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Posted by admin on Apr 1, 2014 in |
The colon is a site where both local and systemic delivery of drugs can take place. Local delivery allows topical treatment of inflammatory bowel disease. However, treatment can be made effective if the drugs can be targeted directly into the colon, thereby reducing the systemic side effects. The aim of the present research work was to develop sustained release multi-layered formulation of Methotrexate, targeted to colon by using the combination of pH- dependent release, timed release and microbially triggered system. Multi-layered tablets were prepared by wet granulation technique method using starch paste as binder. Prepared formulations were subjected to various studies like hardness, friability, thickness, % drug content, weight variation etc. The influence of core tablet compositions, polymer combination ratios and coating levels on the in vitro release rate of Methotrexate from coated tablets was investigated. The results showed that less than 10% drug was released within %hrs (0.1 N HCl for2 hr and phosphate buffer pH 7.4 for 3hrs), and about 40% of the drug was released in...
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Posted by admin on Apr 1, 2014 in |
In this paper, an attempt was made to develop a Group-Quantitative Structure Activity Relationship (GQSAR) model on a series of substituted Quinoline derivatives as anti-Tubercular agents. The dataset was fragmented based on substitution points on the quinolone ring. Various 2D descriptors were calculated and used in the present analysis. For model validation, the dataset was divided into various training and test sets using sphere exclusion method. The developed G-QSAR models were found to be statistically significant with respect to training (r2>0.7), cross-validation (q2>0.6), and external validation (pred_r2>0.5). The developed GQSAR model suggests that substitutions on fragment R4 have an important role in determining biological...
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Posted by admin on Apr 1, 2014 in |
ABSTRACT: The main objective of the study is to promote awareness and assess the knowledge of adolescents on medication use, importance of balanced diet and physical activity. The study was conducted among the adolescents’ aged from16-18 years in regions of Guntur. The volunteers are allowed to fill their informed consent to be a part of the study. The questionnaire was distributed to all the volunteers included in the study, which includes questions on their medication taking behaviour, dietary habits and physical activity. The response was then analysed to assess the knowledge on medication use, balanced diet and physical activity. Among the 165 individuals on assessment of their medication taking behaviour 78% of them do not follow their prescription, 61% of the individuals do not have any idea on their medication use and a majority of 74% are not aware of the unwanted effects caused by the medication. On assessment of their dietary habits and physical activity, 62% of the individuals include meal rich in fat, 42% of the individuals...
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