Posted by admin on Feb 1, 2014 in |
The toxicity profile of alcoholic extract of roots ofTragia cannabina Family: Euphorbiaceae was studied in wistar rats. The multiple oral administration of extract at single dose of 100, 500, 1000, 2000 and 3000 mg/kg body weight for 24 hrs. did not produce sign of toxicity, behavioral appearance, change on a gross appearance. The sun-acute toxicity was determined by administration of graded dosage (125, 250, and 500 mg/kg body weight; orally) of the extract daily for 28 days and the effect on body weight, organ weight and serum biochemical parameters were estimate. Body weight of dose and control rat increase throughout the duration of treatment. Our data demonstrate significantly no difference in serum concentration of aspartae amino transferase, alanine amino transferase, alkaline phosphate, protein, urea, creatinin were measured. The results showed that subacute treatment did not shows any change in corporal weight and hematological parameters. However, a change in liver weight but not in hepatic enzymes was observed. This suggests that the liver function is not altered by Tragia cannabina...
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Posted by admin on Feb 1, 2014 in |
The effects of 4-thiazolidinone-derivative – Les-589 as perspective anti-hypoxic agent under the experimental hypoxic hypoxia actions were studied. The values of peripheral blood and hematological indexes as well as parameters of cellular oxidative metabolism (level of lipoperoxidation products, activity superoxide dismutase and catalase, levels and ratio of lactic and pyruvic acids in the blood and liver tissue) of the experimental animals were investigated. The presented data confirm the anti-hypoxic properties of the Les-589 under study conditions and are the strong argument for further Les-589 study as perspective antihypoxant with preventative...
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Posted by admin on Feb 1, 2014 in |
The present study was performed with an objective to assess knowledge, awareness, frequency indication and pattern of uses and attitude towards Non-Steroidal anti-inflammatory drugs (NSAIDs) among the scholars. In this survey based qualitative research, 591 respondents from the C.S.J.M. University campus, Kanpur, were screened out during the changing weather of north India (January–February 2013) with the help of Questionnaire. All the respondents were having the experience of pain- 61.08% headache, 31.64% backache, 21.31% joint pain, 16.36% menstrual pain, 13.19% sport or exercise related pain; and as analgesic the aspirin and paracetamol with or without ibuprofen were found to be most commonly used drugs among 63.75% NSAIDs user as pain reliving remedy. 51.6% had taken drug multiple times in a day while 28.93% of them took multiple doses at a time. 53.3% of scholars were unaware about such irrational pattern and adverse effects of these NSAIDs, although they were pursuing higher studies. While 46.7% scholars, who were aware about some of the ADRs of NSAIDs were belonging to pharmacy (78.61%)...
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Posted by admin on Feb 1, 2014 in |
The objective of this study was to determine antibiotic susceptibility pattern of methicillin resistance Staphylococcus aureus in tertiary care center at Southern Rajasthan. Modified Kirby Baurer disc diffusion method was used for antimicrobial sensitivity testing of all samples. Maximum resistance among Staphylococcus aureus isolates (n=400) was observed against Methicillin (59%), Amikacin (53%) followed by other antimicrobial agents. Earlier Vancomycin, Linezolid and Pristinamycin were 100% sensitivity to MRSA. But results of this study shows that among MRSA isolates 13 % were found resistant to Vancomycin (VRSA), 12 % isolates found resistant to Linezolid and 9 % isolates Pristinamycin resistant. Pristinamycin was found sensitive in 75% of MRSA which were also Vancomycin resistant (VRSA) and Linezolid resistant (LRSA). The emergence of drug resistance and it’s dissemination in MRSA is worrisome. So we need to develop newer agents as well as slow down the spread of resistant strains by various...
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Posted by admin on Feb 1, 2014 in |
During the obtainment of herbal products, standardization of raw plant materials is ensured by the quality of herbal drugs, of the extraction conditions, followed by the determination of the content of one or more components or of the most representative compounds of their composition, which are adjusted to values previously defined, resulting in greater uniformity of plant derivatives, important for the production of safe and effective medicines. This study aimed to analyze the marker (3′, 4′, 7-tri-O-methoxyflavone) content of Peperomia pellucida L. (HBK) in three periods of collection in order to assess the seasonal changes and different extraction methods (maceration and percolation) with different solvent concentrations. The highest incidence of rain over a given period does not influence the marker content present in the sample. The maceration using 70% of ethyl alcohol obtained the highest marker content...
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