Posted by admin on Jan 1, 2014 in |
Microspheres are the carrier linked drug delivery system in which particle size ranges from 1-1000μm. Microspheres constitute an important part of drug delivery systems by virtue of their small size and reliable means to deliver the drug to the target site with specificity. However, the advantages of microspheres are limited due to their short residence time at site of absorption. This can be achieved by coupling bioadhesion characteristics to microspheres and developing “mucoadhesive microspheres”. Glipizide is an oral hypoglycemic drug with short half-life. So to provide prolonged action glipizide microspheres were prepared by ionic gelation technique using different concentration of mucoadhesive polymers. The prepared microspheres were characterized for various physicochemical prarameters such as particle size, percentage yield, encapsulation efficiency, scanning electron microscopy, in-vitro drug release and kinetics study. The in-vitro drug release studies were performed in buffer media and shown the controlled release pattern of drug up to 10 hours. Drug release from the microspheres was found following zero order release kinetics with non-fickian release mechanism. The satisfactory results...
Read More
Posted by admin on Jan 1, 2014 in |
A food borne illness or disease is exactly what the term indicates a disease or illness caused by the consumption of contaminated foods or beverages. It would seem rather obvious that a food borne microbial pathogens, or a microbial toxic product, or another poison such as a poisonous chemical that has somehow contaminated the food and beverages leads to one of the many different food borne illness. Many microorganisms present are associated with infection, spoilage and contamination of food in home, restaurants, dhabas and other various sites. We collected and isolated bacterial and fungal strains by various morphological characteristics, biochemical identification etc. Disc diffusion method was used to study antibiotic resistant capability against infectious microorganisms. In the antibiotics Kirby Bauer (disk diffusion) test only 3 tested S. aureus displayed a inhibition zone against some antibiotic, and they resistant against by Amoxicillin, Oxacillin, Ciprofloxin, but sensitive to Doxycycline, Erythromycin. We tested Bacillus subtilis and Pseudomonas also by antibiotic disc diffusion method and observation of investigators in which only few antibiotics...
Read More
Posted by admin on Jan 1, 2014 in |
Olanzapine is a thienobenzodiazepine class of drugs, which has been approved by the Food and Drug Administration (FDA), for the treatment of schizophrenia, depressive episodes associated with bipolar disorder, acute manic episodes, and maintenance treatment in bipolar disorder. Recently many formulations developed such as parenteral formulations to improve compliance in the treatment of schizophrenia and to treat agitation in patients with schizophrenia and bipolar mania. Olanzapine palmate long acting injection (depot) is a novel formulation of the atypical antipsychotic Olanzapine. The aim of the study is to prepare tablet with similar elegancy, therapeutically effective, bioequivalent formulations to that of zyprexa. Here Olanzapine tablets were prepared by wet granulation method using following ingredients: Lactose monohydrate, Mannitol, L-HPC, Microcrystalline cellulose, Crospovidone, HPC EX, HPC LF, Magnesium Stearate, HPMC, Poloxamer, pectin. The tablets were evaluated for weight variation, thickness, hardness, friability, disintegration, dissolution and stability study for the best formulation F10 which is having similar release profile as that of zyprexa. Content uniformity of F10 formulation is 99-99.6%. Total impurities for the...
Read More
Posted by admin on Jan 1, 2014 in |
The aim of the study was to evaluate the effect of Musa sapientum methanolic fruit extract on volume of gastric juice and pepsin activity in aspirin induced peptic ulcer in albino rats. The extract was prepared by percolation method. Volume of gastric juice was estimated by the method of Deshpande SS et al (2003). Pepsin activity was studied with the methods of Debnath PK et al (1974) and Lowry OH et al (1951). Twenty four healthy albino rats of 100-200 gms were divided into 4 groups of six animals each. Group I or control (3% gum acacia, 5 ml/kg orally for 7 days). Group II or experimental control (aspirin 400 mg/kg orally single dose on the 7th day). Group III or MSE group (MSE 100 mg/kg orally for 7 days and aspirin 400 mg/kg orally single dose on the 7th day). Group IV or standard (ranitidine 150 mg/kg orally for 7 days and aspirin 400 mg/kg orally single dose on the 7th day). On 8th day the stomachs of...
Read More
Posted by admin on Jan 1, 2014 in |
Kushta literally means burning of drugs of metallic, mineral or animal origin into their ash. Qalai (tin) based Unani compound formulation Kushta qalai (KQ) is used since antiquity for the treatment of various ailments. Although it is used on consistent basis by Hakims but at present there are no scientific data available about its quality control parameters. So, in this research article an emphasis is given on preparation and physicochemical assessment of KQ using classical as well as modern scientific parameters with an eye towards its standardization. In finished product floating test, grain floating test, thumb finger test and fineness test were positive. The mean value of bulk density and tapped density were 1.32±0.00gm/ml and 2.24±0.02gm/ml respectively. Hausner’s Ratio and Compressibility Index were 1.77±0.02 and 44.15±0.86% respectively. pH in 1% and 10% solution were 10.47±0.00 and 11.17±0.02 respectively. Loss of weight on drying was 0.019±0.00%. Total ash, acid insoluble ash, water soluble ash and water insoluble ash were 96.47±0.07%, 36.87±0.06%, 5.1±0.10% and 91.64±0.20% respectively. The water soluble extractive value...
Read More
