Posted by admin on Feb 1, 2014 in |
Clitoria ternatea Linn is used both in traditional system and folk medicine to treat various inflammatory diseases such as arthritis and burns. The aim of the present study was to evaluate the analgesic and anti-inflammatory activity on scientific basis of different extracts of Clitoria ternatea Linnusing carrageenan-induced paw edema and tail flick method in rats respectively at various dose levels. From the results obtained among different extracts, only ethanol extract (400 mg/kg) showed maximum inhibition (23.80%) at 6th h and the early onset of action was found at 3rd h with only petroleum ether extract (400 mg/kg) showed statistical significant effect (p<0.001) compared to positive control group. Petroleum ether extracts (100 mg/kg, 200 mg/kg & 400 mg/kg) showed statistical significant inhibition from 4th to 6th h. In analgesic activity, both ethanol & petroleum ether extract showed the same type of effect but ethanol treated extract exhibited long lasting effect up to 2 h. The findings of the study proved justification of the use of the plant in the treatment...
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Posted by admin on Feb 1, 2014 in |
In the present study, different extracts of Lophopetalum javanicum (Zoll) leaves were evaluated for erythrocyte membrane stabilizing and thrombolytic activities. Phytochemical analysis of the plant was also performed to detect presence of different kinds of phytoconstituents. In order to predict anti-inflammatory activity the plant extracts were subjected to check erythrocyte membrane stabilization using heat and hypotonic solution induced hemolysis method. The crude methanolic extract, the aqueous and chloroform, pet-ether soluble fractions of L. javanicum leaves demonstrated strong membrane stabilizing activity compared to acetyl salicylic acid. In thrombolytic study, the crude methanolic extract, pet-ether, chloroform and carbon tetrachloride soluble fractions demonstrated strong thrombolytic activity in human blood specimen. Phytochemical screening revealed the presence of flavonoids, steroids, tannins and triterpenoids as major constituents in the extracts of the plant which may be responsible for the observed biological...
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Posted by admin on Feb 1, 2014 in |
An isocratic, reversed phase HPLC method was developed, using an Inertsil ODS C8 (100 x 4.6) mm,5u column and the mobile phase containing an homogenous mixture of buffer and acetonitrile (65:35,v/v). The flow rate of the mobile phase was maintained at 1.0ml/min and the detection was carried out at wavelength 250 nm. The developed method was validated with respect to linearity, accuracy (recovery), precision, system suitability, selectivity, ruggedness to prove the stability indicating ability of the...
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Posted by admin on Feb 1, 2014 in |
The aim of this article was to develop pidotimod dispersible tablet and optimize the ingredients for the tablets. The effect of ingredients (diluents, disintegrants and lubricants) on the characteristics of the tablets was evaluated. The pidotimod dispersible tablets were prepared by wet granulation. The effect of diluents on the tablets was investigated by Carr’s index, dissolution, hardness, friability and taste. The effect of disintegrants on the tablets was determined by dissolution and cost. And the effect of lubricants on the tablets was studied by weight, hardness and dissolution behavior. The results showed that the optimum proportion was 400mg pidotimod, 120mg MCC, 80mg mannitol, 120mg CMS-Na, 60mg lactose, 20mg aspartame, 10mg magnesium stearate and 6%PVP 50% ethanol solution. Pidotimod dispersible tablets with optimum proportion showed acceptable taste, hardness, friability, dissolution behavior. The preparation process was simple and the tablets could be prepared by ordinary tablet production equipment. So it is suitable for mass industrialized production. The final tableting formulation and the simplified process both had tremendous potentials in commercial large-scale...
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Posted by admin on Feb 1, 2014 in |
The liquisolid technique is a novel concept, where a liquid may be transformed into a free flowing, readily compressible and apparently dried powder by simple physical blending with selected carrier and coating material. The in vitro dissolution property of poorly water soluble Nifedipine was improved by exploring the potential of liquisolid technique. Different liquisolid tablets were prepared by suspending Nifedipine in PEG 400 with Avicel PH 102 as carrier, Aerosil 200 as coating material and Sodium starch glycolate as disintegrating agent. The liquid load factors for liquid vehicle was calculated to obtain the optimum amounts of carrier and coating materials necessary to produce acceptable flowing and compactable powder admixtures viable to produce tablets. The formulated liquisolid tablets were evaluated for post compression parameters such as weight variation, hardness, friability and drug content uniformity. The interaction between drug and excipients in prepared Liquisolid tablets were studied by differential scanning calorimetry (DSC) and FT-IR. The result showed that liquisolid formulation of Nifedipine exhibited higher percentage of drug release than directly compressed...
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