Posted by admin on Feb 1, 2014 in |
The purpose of this study was to develop and optimise the formulation of mucoadhesive patches of Diltiazem hydrochloride using chitosan as base matrix. The patches were prepared by solvent casting method. PVP (K30) and propylene glycol were introduced into the patches formulae to improve the filming properties. The patches were found to be smooth in appearance, uniform in thickness, weight, and drug content and also showed good mucoadhesive strength and folding endurance and moderate swelling properties. The permeation study of the patches indicated a drug release of 80% in 10 hrs. The data analysis of the release profile using Peppas model indicated a non Fickian type of release profile. It can be concluded that buccal patch of Diltiazem hydrochloride can be an alternate for improving bioavailability with a control release...
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Posted by admin on Feb 1, 2014 in |
Tiemonium Methylsulfate is an antispasmodic drug. It strengthens calcium bonding with phospholipids and proteins. A simple, sensitive and highly accurate UV spectroscopic method has been developed for the determination of Tiemonium Methylsulfate in bulk and its tablet dosage form. Tiemonium Methylsulfate in its distilled water solutions was determined at the wavelength range of 200-400 nm by the spectroscopic method. Solution of Tiemonium Methylsulfate in distilled water shows a maximum absorbance at 234 nm. Beer’s law was obeyed in the concentration of 10-30µgmL-1, correlation coefficient, detection and quantification limit were also calculated. The proposed method has been applied successfully to assay of Tiemonium Methylsulfate in pure and tablet dosage form. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The percentage of assay of Tiemonium Methylsulfate in tablet was 99.90-100.12% of the label claimed 50 mg per tablet. The method was then validated statistically as per ICH guidelines which yielded good results concerning range, precision, accuracy, reproducibility, specificity and...
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Posted by admin on Feb 1, 2014 in |
The human fungal infections have increased tremendously in our country, especially candidal infections. Cryptococcus neoformans is encapsulated yeast, causes life-threatening infections in immuno-compromised individuals such as AIDS. Meningoencephalitis is the serious consequence of C. neoformans infection. Studies are therefore, required for identification of these fungal agents and search for suitable antifungal therapy. Keeping this in view, Candida spp. and Cryptococcus neoformans strains were characterized. Also, the comparative in vitro antifungal susceptibility to conventional Amphotericin B (AMB-d) and Indian Liposomal Amphotericin B (FungisomeTM) shall be determined. Candida albicans, non-Candida albicans and Cryptococcus neoformans strains originating from clinical cases have been characterized using phenotypic methods and selective virulence traits. The isolates were obtained from National Culture Collection of Pathogenic Fungi, PGIMER, Chandigarh, India. The MIC ranges of conventional Amphotericin B (AMB-d) and Indian Liposomal Amphotericin B, FungisomeTM against all the strains of Candida spp. and Cryptococcus neoformans were also determined. Both the fungal genera could be identified using various phenotypic characteristics and selective virulence factors. The MIC ranges of FungisomeTM ranged...
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Posted by admin on Feb 1, 2014 in |
The aim of this study was to evaluate the behavioural, muscle coordination and anxiolytic activities of methanolic extracts of Sophora interrupta (papilionaceae) in mice. The behavioural, muscle coordination and anxiolytic activities were evaluated by using various models of CNS using mice. Diazepam was used as standard drug for muscle coordination and anxiolytic studies. The extracts were administered orally at 400 mg/kg. The results of the present study indicates that the methanolic extract of Sophora interrupta leaves are effective in inducing a significant protection against behavioural, muscle coordination and anxiolytic activities, as evidenced by various CNS models with respect to control. This study confirmed the behavioural, muscle coordination and anxiolytic activities of this plant as it is used in traditional...
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Posted by admin on Feb 1, 2014 in |
The aim of the study was to develop sustained release matrix tablet of Losartan potassium and to evaluate its efficacy in reducing hypertension. In this experiment, sustained release matrix tablets were prepared by direct compression method and Methocel K4M CR and Methocel K100M CR were used as polymer. The evaluation involves three stages: the micromeritic properties evaluation of powder blend, physical property studies of tablets and in-vitro release kinetics studies. The powder blend was evaluated for angle of repose, loose bulk density, tapped bulk density, Carr’s index, Hausner’s ratio, moisture content and total porosity and the tablets were evaluated for hardness, friability, thickness, drug content and in vitro dissolution parameters. The weight variation was observed to be within the prescribed limits for each formulation. In vitro release studies were carried out using USP apparatus type II at 100 rpm and dissolution medium consisted of 0.1N hydrochloric acid for the first 2 hours and phosphate buffer pH 6.8 from 3 to 24 hours, maintained at 37±0.5°C. Drug release at different...
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