Posted by admin on May 1, 2014 in |
BCR-ABL Tyrosine Kinase inhibitor is an ideal pharmacological target for Chronic Myeloid Leukemia (CML). After the effective use of Imatinib as a therapeutic agent for Chronic Myeloid Leukemia, resistance has been observed in much patience with the treatment of Imatinib. The main objective of this study is to develop some new novel BCR-ABL Tyrosine Kinase inhibitor for the treatment of Chronic Myeloid Leukemia by Structure Activity Relationship (SAR) and Pharmacophore based drug design approach with Imatinib as a prototype drug. Moreover to overcome the resistance with Imatinib and get some new innovative BCR-ABL Tyrosine Kinase inhibitor with increased potency. In this study, we have designed some new BCR-ABL Tyrosine Kinase inhibitor and reported them as potentially new BCR-ABL Tyrosine Kinase inhibitor by using molecular docking analysis and various free internet based Insilco tools. The drug properties like toxicity, metabolic site, Binding energy, Inhibition constant, Ligand efficiency and many other parameters are predicted through In-silico...
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Posted by admin on May 1, 2014 in |
Bacteriocins are proteinaceous substance produced by bacteria to inhibit the growth of similar or closely related bacterial strains. They are typically considered to be narrow spectrum antibiotics produced by both gram negative and gram positive range of bacteria which possess antimicrobial properties and inhibitory towards sensitive strains. Bacterocins are safer than antibiotic. They can be used from natural material (probiotics). Bacteriocins of lactic acid bacteria are considered as safe natural preservatives or bio preservatives. A total of nineteen colonies were picked from the various samples i.e. Curd, Condensed milk, Soil and Raw milk. All were subjected to bacteriocin assay and a total of six (6) strains showing relative positive results were selected and subjected for further characterization. Among all six (6) isolates (P1, R3, R6, R7, R8, T7), P1and R7 strains showed promising results against various test organisms with the observed bacteriocin activity. During preservative studies, addition of cell free bacteriocin extract of P1 strain showed positive result for preservation of raw milk up to 4days without any change...
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Posted by admin on May 1, 2014 in |
Phytochemicals are non-nutritive chemical constituents of plants which occur naturally in it such as Steroid, Terpenoids, Tannins, Carotenoids, Flavonoids, Alkaloids and Glycosides. The aim of the present study was to carryout qualitative and quantitative phytochemical analysis of ethanolic and 50% ethanolic extracts of Tinospora cordifolia (stems), Momordica chirantia (fruit), Cucurbita maxima (fruit) and Raphanus sativus (root). The result of the qualitative phytochemical screening revealed the presence of various secondary metabolites with highest activity in 50% ethanolic extracts of T. cordifolia, C. maxima and ethanolic extract of Tinospora cordifolia. Quantitative phytochemical analysis revealed that the total flavonoids content was found to be varied in different extracts wherein high activity was noted in 50% ethanolic extract of T.cordifolia (9.91 ± 1.46 mg CE/gm)followed by 50 % ethanolic extract of Cucurbita maxima (9.79 ± 0.35 mg CE/gm)and absolute ethanolic extract of T.cordifolia (9.75 ± 0.4 mg CE/gm) among all 8 tested extracts. Total phenol content was significantly high in 50% ethanolic extracts of Tinospora cordifolia (24.70 ± 2.04 mg GAE/gm) followed by...
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Posted by admin on May 1, 2014 in |
Montelukast Sodium is a leukotriene receptor antagonist (LTRA) used for the treatment of asthma and to relieve symptoms of seasonal allergies. In present research work an attempt has been made to prepare mouth dissolving films of Montelukast Sodiumwere prepared using different polymers like PVA, HPMC by solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling index, surface pH, in-vitro disintegration time, drug content, drug polymer compatibility (IR Study), and in-vitro drug release. The physical appearance and folding endurance properties were found to be good and electron microscopy shows that films are clear, colorless with smooth surface without any scratches. The surface pH was found to be in the range of 6.35 to 6.75 which is close to salivary pH, which indicates that films may have less potential to irritate the oral mucosa, thereby they are comfortable. The drug content of all the films was in the range of 95.54 to 98.68 suggesting that drug was uniformly dispersed throughout all films. The In-vitro disintegration time of...
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Posted by admin on May 1, 2014 in |
Aim: To evaluate the antidiarrhoeal activity of methanolic leaf extract of Anogeissus latifolia. Material and Methods: The methanolic extract was evaluated using rodent animal models like castor-oil induced diarrhoea and castor-oil induced enteropooling. The phytochemical constituents were also planned to screen by using standardized methods. The plant is traditionally used for the treatment of dysentery, snakebite, lepsory, diabetes, wounds and ulcers & skin diseases. Thus, the present study is therefore undertaken to investigate the antidiarrhoeal activity. Result: The methanolic extract of Anogeissus latifolia given orally at the dose of 200 and 300 mg/kg, showed significant antidiarrhoeal activity in castor oil induced diarrhoea by decreasing fecal episodes, and castor oil induced enteropooling by decreasing the volume of intestinal fluid. Conclusion: The results suggested that the extract may contain biologically active component that may be useful against diarrhoea, thereby validating its mention in the ancient Indian texts and justifying its use in ethanomedical...
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