Posted by admin on Jul 31, 2023 in |
Transfersomes, which may penetrate mammalian skin, are notably ultra deformable (ultraflexible) lipid supramolecular aggregates. A type of formulation carrier system called a transfersome can transport medications with both low and high molecular weights transdermally. Transfersomes enter the underlying viable skin in an undamaged state through skin’s stratum corneum pores that are smaller than its size. The major goal of the transferosome in treating the condition psoriasis is drug penetration through the skin. However, the stratum corneum is the most formidable defence against drug penetration via the skin. In order to assist penetrate the stratum corneum barrier, the use of lipid vesicles like transfersomes in delivery systems has attracted increasing interest in recent years. The current study set out to statistically improve the vesicular formulations (Transfersomes) of a model medicine, boswellic acid which is obtained from Boswellia serreta known as for the treatment of...
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Posted by admin on Jul 31, 2023 in |
The Present study was planned to gauge the immune-modulatory activity of the ethanolic extract and the isolated compound Stachydrine from the leaves of Capparis sepiaria L. (Capparidaceae). The study was extended to research the chemical compounds within the EECS (Ethanolic Extract of Capparis sepiaria). The preliminary phytochemical screening revealed that EECS evidenced the presence of varied phytoconstituents like alkaloids, glycosides, reducing sugars, flavonoids, saponins, starch and terpenoids. The alkaloidal compound Stachydrine was isolated and further evaluated by using UV, IR and NMR. Both in-vitro and in-vivo studies were administered to gauge the immunomodulatory effect of ethanolic extract of C. sepairia and the isolated alkaloid Stachydrine using Phagocytosis and Jerne plaque assay. Both ethanolic extract (25.82% for 70mcg/ml) and the isolated compound (21.28% for 25 mcg/ml) showed the enhancement of phagocytic index compared to regulate (18%) also because the number of plaques proportional to the amount antibody-producing lymphocytes within the cell population after the treatment with extract of C. sepiaria (551.25± 4.26 and 620 ± 7.25 for the 100mg/kg and...
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Posted by admin on Jul 31, 2023 in |
A number of the population in developing countries use herbs and herbal products to treat various diseases including malaria. However, most of them have not been evaluated for their efficacy and toxicity and their use is not standardized in some instances. Poly-herbal extracts may yield better treatment outcomes compared to extracts from a single plant due to the combined effects of bioactive compounds from the multiple sources. Cassia obtusifolia and Hyptis suaveolens are two plants commonly used in herbal preparations for treating malaria in Ghana. This study was to investigate Plasmodium falciparum asexual growth inhibitory activities of the individual and combined leaf extracts of the two plants. Leaves of the C. obtusifolia and H. suaveolens were extracted separately with methanol, ethanol and water. The six extracts, as well as in combination were evaluated in a dose-dependent manner for their antiplasmodial activities against the chloroquine-sensitive Plasmodium falciparum 3D7. Aqueous extract of C. obtusifolia, including the mixture of the two plants were highly active with mean IC50 less than 4.0 µg/mL....
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Posted by admin on Jul 31, 2023 in |
Objective: This work aims to evaluate in in-vivo the Antiarthritic and Anti-inflammatory activities and in-vitro antioxidant activity on Poly Herbal Formulation in rats. Method: Arthritis is a disorder of change in joint architecture and ligament degeneration. In this polyherbal formulation, medicinal plants were Zingiber officinale (33.931mg), Piper nigrum (33.931), Piper longum (33.931mg), Spergularia daemia (30 mg), Delonix elates (30 mg), Acalypha indica (30 mg), and Carum copticum (101.79 mg), which are well-known plants throughout India. They are commonly used to treat various disorders like cancer, diabetes, arthritis, rheumatoid arthritis, atherosclerosis, and chronic inflammatory disorders. The quality of finished products was evaluated as per the World Health Organization’s guidelines for the quality control of herbal materials. Arthritis and inflammation were induced in both male and female Sprague-Dawley rats. Freund’s complete adjuvant (FCA) is used for antiarthritic effect. Carrageenan-induced is used for the anti-inflammatory effect of polyherbal formulation (Rheumatigo) was studied at doses of 250 and 500 mg/kg and the effects were compared with prednisolone (10 mg/kg) and diclofenac (20 mg/kg)....
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Posted by admin on Jul 31, 2023 in |
Post-COVID syndrome is defined as COVID-19 associated illness that extends for more than three weeks from the onset of symptoms, and chronic COVID-19 is an illness that extends beyond 12 weeks from the onset of symptoms. An online survey was conducted where 400 Covid-19 infected, participated from various areas of India. Among 400, 58% (232) had complaints of persistence of Covid symptoms. The most common long-term clinical manifestations identified based on this study include fatigue, cough, shortness of breath, and myalgia. Patients who exhibit symptoms such as fatigue, cough, and shortness of breath early in their condition are more prone to developing post-COVID syndrome. The results show that long-term clinical manifestations after mild and moderate COVID-19 are common and lead to limitations of activities and participation. However, in most cases, they are not severe and do not lead to frequent or serious issues with quality of life or workability. Thus, early rehabilitation is needed during the acute phase of illness, including mobilization, psychological support, and respiratory...
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