Posted by admin on Mar 1, 2014 in |
Inflammation is a cellular reaction to injury and plays a central role in pathophysiology of a variety of diseases.Oil derived from Emu (Dromais novaehollandiae) fat, is reported to have healing property. The present investigation was performed to demonstrate in vivo anti-inflammatory effect of Emu oil using phorbol ester induced acute inflammatory ear edema model. Also, the efficacy of Emu oil was compared with Virgin Coconut Oil extracted from coconut (Cocos nucifera) which is traditionally being used in India. Acute inflammation was induced applying 20 μl of 2% Croton oil (a phorbol ester) in Swiss Albino mice inner pinna. After 2 hours, ears were treated with single application of 20 μl of Emu oil and Virgin Coconut oil. Pinna thickness was measured pretreatment and 6 and 24 hours of post treatment. After 24 hours, animals were euthanized and ear punches were collected and weighed. Peak edema was evidenced at 2 hours of croton oil application. Emu oil and Virgin Coconut oil significantly attenuated croton oil induced inflammation. Inhibition of edema...
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Posted by admin on Mar 1, 2014 in |
Acetylcholine satisfies all criteria for a transmitter substance. Its most widely recognized action sites are the endings of vertebrate motor nerves, the endings of the automatic pre ganglionics and the parasympathetic post ganglionics. It appears also to be the transmitter of motor nerves in all advanced invertebrate animals except the arthropods where it seems to separate at the endings of sensory nerves. Acetylcholine is concerned with various visceral functions in both invertebrates and vertebrates. The impact of 20% ethanol (w/v) at selected doses of 5gm/kg wt over 5 and10 weeks in vivo and 100-1000 µl in vitro on the heart and aortic tissue acetylcholine content activity was reported. Alcohol is selected doses appeared to inhibit the rat and aortic tissue based Ach levels both in vitro and in...
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Posted by admin on Mar 1, 2014 in |
The pet ether and chloroform extracts of Durenta repens leaves was screened for antidepressant action in tail suspension model. Both the extracts showed antidepressant action at the dose of 200mg/kg. Chloroform extract produced significant (p<0.001) mobilisation of the animals when compared with that of the standard drug Imipramine (10mg/kg) and acts as a potent centrally acting antidepressant drug. Results obtained for pet ether extract was not significant in treating the depression in the animal model. The antidepressant action may be mediated by the centrally releasing catecholamine’s possesses antidepressant...
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Posted by admin on Mar 1, 2014 in |
Herbal medicines are gaining more and more attention all over the world, due to their long historical clinical usage and comparatively less side effects. Standardization of herbal drugs and their quality control is needed with proper integration of modern scientific techniques and traditional knowledge. The analysis and quality control of herbal medicines are moving towards an integrative and comprehensive direction, in order to better address the inherent holistic nature of herbal medicines. The techniques used in standardization of plant material include its morphological, anatomical and biochemical characteristics. The present study highlights the pharmacognostical studies including parameters such as powder analysis by microscopical evaluation, and study of physicochemical parameters i.e. proximate analysis and preliminary phytochemical screening of seed kernel of Caesalpinia bonducella Linn. and fruits and roots of Coccinia indica Wight & Arn. which are used as antidiabetic agents. The present study, thus, will help to provide important information with respect to the proper identification of the plant for utilization in different herbal...
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Posted by admin on Mar 1, 2014 in |
The main aim of the extended release tablets is to reduce the dose frequency and to improve the patient compliance. The objective of the present study was to formulate and optimize the extended release tablets of Pramipexole dihydrochloride monohydrate for 24hrs, which made the advantage of this formulation as once daily with more patient compliance. The combination of different hydrophilic polymers and hydrophobic polymer in varying concentrations were used to get the desired extended release profile over a period of 24 h. The drug and excipients mixed granules was subjected to evaluate the physical properties like angle of repose, bulk density, compressibility index were found to be satisfactory. The hydrophilic polymer Hydroxy propyl methyl cellulose (HPMC K200M) at 41.7% and( HPMC E 3LV) at 5% in combination with hydrophobic polymer (Eudragit L100) at 5% level produced desired extended release Pramipexole dihydrochloride monohydrate matrix tablets. The in vitro drug release of optimized formulation (F9) was 99% and was more release than innovator product of Mirapex ER (94.5%) which extended up...
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