Posted by admin on Jan 1, 2014 in |
In this study, the methanol extract of bark of Cordia dichotoma Forst., belonging to the family Boraginaceae was prepared by successive extraction procedure ( petroleum ether, ethyl acetate, methanol) in soxhlet apparatus and subsequently, the extract was evaluated for its phytoconstituents and pharmacological activity. Comparatively, higher yield (7.11%) of methanol extract was obtained. Phytochemical tests revealed the presence of alkaloid, glycosides, proteins, amino acids, phenolic compounds, flavonoids, tannins and saponins in the extract. The methanol extract was evaluated for its in vitro antioxidant property by 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical assay; sodium nitroprusside generated nitric oxide (NO), hydrogen peroxide (H2O2).Total phenolic content and total flavonoid contents were also carried out. The extract showed IC50 values of 62.46 µg/mL, 48.75µg/mL, 63.5 µg/mL for DPPH free radical, total phenolic content and flavonoid content, respectively. The current study is carried out to investigate the free radical scavenging potential of methanolic extract of bark of Cordia dichotoma using in-vitro models. These models demonstrate antioxidant activity in a concentration dependent...
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Posted by admin on Jan 1, 2014 in |
Comparative antibacterial study of ethyl acetate extract of Cuscuta reflexa parasite grown on Cassia fistula and Ficus benghalensis was performed using disc diffusion method. Four different concentrations, 50, 100, 150 and 200 mg/ml of ethyl acetate extract of Cuscuta reflexa grown in two different host plants were prepared and tested against Escherichia coli, Bacillus subtilis, Klebsiella pneumoniae, Staphylococcous aureus and Salmonella typhi in disc diffusion method. Cuscuta reflexa extract from both the host trees showed effect but difference in their activity to the test organisms was found. Significantly higher activity was shown by Cuscuta reflexa grown on Cassia fistula against all the pathogenic bacteria and produced zones of inhibition ranging from 14.18-22.5 mm at 100 mg/ml concentration but extract was found inactive against Salmonella typhi at all tested concentration. In the same way Cuscuta reflexa grown on Ficus benghalensis was active against all the bacterial strains and produced zones of inhibition ranging from 10.4-12.98 mm at 100 mg/ml concentration but extract was found inactive against Escherichia coli at all...
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Posted by admin on Jan 1, 2014 in |
The purpose of this study is to prepare a bilayer gastro retentive tablet of Propranolol HCl using direct compression technology and optimize the type and concentration of polymer to give maximum retentive effect with good drug release profile. Propranolol hydrochloride, a nonselective β-adrenergic blocker having short half-life (3-4 hr)and first pass metabolism favors for sustained release dosage form. In this study, a bilayer tablet was prepared which contains an immediate release portion and a floating layer. Gaur gum, Pectin were used as gel forming agents either alone or in combination, Sodium bicarbonate and citric acid as gas generating agent, superdisintegrant sodium starch glycolate for the fast release layer. The formulations gave an initial burst effect to provide the loading dose of the drug followed by sustained release for 14 h from the sustaining layer of tablets. The bilayer tablets were characterized by lag time, floating time, weight variation, drug content and dissolution profile. Best Formulation BFT1 [Gaur gum-Pectin (2:1)] shows lag time of 8.0min, floating time of 14 h...
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Posted by admin on Jan 1, 2014 in |
The aim of current research work was to develop sustain release formulation of Theophylline. Modified plant derived Fenugreek gum (FG) polymer was synthesized and used as matrix forming agent. Matrix tablet formulations were prepare by wet granulation technique using modified fenugreek gum in different concentration. The prepared formulations were evaluated for physical properties such as tablet hardness, weight variation, drug content and In vitro drug release. Formulation prepared with drug: polymer weight ratio of 1:2 showed desired release profile as per USP specification. FTIR study showed absence of chemical interaction between drug and polymer. The optimized formulation was found to show stability for two month as per ICH guideline. Study suggested that modified fenugreek gum can be used as extended release...
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Posted by admin on Jan 1, 2014 in |
Croton membranaceus (Mull. Arg.) Euphorbiaceae is a shrub that grows wild in West Africa. It is used by Ghanaian Traditional Medical Practitioners in the treatment of benign prostatic hyperplasia (BPH). Research findings have provided some scientific bases for the use of this plant in the treatment of BPH. Therefore, the aim of the present study was to investigate the antihyperglycaemic and antioxidant activities of C. membranaceus. There isalso evidence suggesting an association between BPH and diabetes through a common pathogenic mechanism. Research findings also suggest that oxidative stress may be one of the major factors responsible for the development of BPH and diabetes. The antihyperglycaemic activity of three different doses (100, 300, 600 mg/kg body weight) of the ethanol (70 %) extract of C. membranaceus root was studied in streptozotocin-induced diabetic rats. The antioxidant activity of the ethanol extract of C. membranaceus root was also investigated using the spectrophotometric 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging method. C. membranaceus root extract showed a dose-dependent reduction of glucose levels over both short term and...
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