Posted by admin on Jan 31, 2024 in |
The present research aims to develop a transdermal Cubosomal gel formulation of Indomethacin, which would attenuate the gastrointestinal toxicities associated with oral administration and also aimed to encapsulate high drug pay load in Cubosomes for improved therapeutic efficiency. Indomethacin is an NSAID commonly recommended for the relief of pain and inflammation. Indomethacin was formulated as Cubosome to avoid the gastric irritaion. Top- down techniques were used for the preparation of cubosomes. Different formulations (F1-F6) were prepared and optimized for better performance in terms of drug content, SEM analysis, Zeta potential, entrapment efficiency and drug release. Then it is formulated into gel using carbopol as gel base. The physical parameters like appearance, pH, viscosity, spreadability, extrudability, ex-vivo drug release and in-vitro skin irritation test using HET- CAM were also evaluated. The cubosomal gel formulation (F5) was found to be clear without any aggregate indicating excellent homogeneity. The ex-vivo drug release study shows that the formulation (F5) has a good release rate. The kinetic study of the optimized formulation (F5) was...
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Posted by admin on Jan 31, 2024 in |
Background: Betel nut and different variants of tobacco and smoking is hazardous causing oral and or pharyngeal squamous cell carcinomas (SCC). In Assam, “Tamol”, a raw, unprocessed betel nut is mixed with lime and betel leafis an alarming factor for oral and oropharyngeal SCC. Aim: To assess the patterns of tobacco, betel nuts and smoking causing variations in morphological differentiation of oral and oropharyngeal SCC. Methods: Morphological variations of 40 oral and oropharyngeal SCC’s were studied. A self answered predesigned questionnaire was used regarding the patterns and years of abuse of tobacco, betel nuts and smoking. Results: 90% of cases show tobacco prevalence, 90% show betel nut prevalence in the form of raw betel nut (58.3%), dried betel nut (27.8%) and betel nut in the form of panmasala/gutkha (13.9%). 50 % show smoking prevalence in the form of beed is (80%), cigarettes (10%) and weeds (10%) respectively. Among 22 cases of well differentiated SCC, 86.3%, 90.9% and 36.3% consumed tobacco, betel nuts and smoke respectively for at least 10...
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Posted by admin on Jan 31, 2024 in |
Oral administration is the preferred route of drug administration owing to its convenience, patient compliance, and cost-effectiveness. The study aspired to augment the solubility and dissolution rate of Rosuvastatin calcium (RST) by using the solid dispersion (SD) technique with various generations of hydrophilic polymers. Hot melt and solvent evaporation methods were employed to prepare SD using various hydrophilic carriers such as Urea, PEG-6000, Poloxamer-F127 and β-cyclodextrin (β-CD). The prepared SD was evaluated and the optimized formulation was subjected to tablet formulation by direct compression method and a quality control test was performed. After screening all the hydrophilic polymers, SD was prepared by using β-CD shows a remarkable increase in solubility and dissolution. Among the ratios 1:1, 1:5 and 1:7, SD with 1:5 showed increased solubility and maximum drug release and shows good surface characteristics were identified by SEM analysis. Finally, the prepared core tablet CF2 was found to have better dissolution efficiency of 96.34% drug release at 60mins, when compared with CF1 (81.46%) and the Marketed tablet (85.44%). The...
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Posted by admin on Jan 31, 2024 in |
Background: Melasma is a frequent hyper pigmentary disorder characterized by the presence of brown to grey patches on the face. For melasma management, various modalities available that includes kojic acid, azelaic acid, Kligman’s regimen, peels like glycolic acid, trichloroacetic acid (TCA), jessner’s etc are in use but unsatisfactory results, recently tranexamic acid (TA) has added to treatment armamentarium for resistant melasma. Objective: To know the efficacy of oral tranexamic acid with glycolic acid 35% peel verses oral tranexamic acid with modified jessner’s peel in treating melasma. Materials and Methods: Present study includes 60 patients with melasma, divided into group A and group B. Group A treated with glycolic acid peel and oral TA and group B treated with modified jessners peel with oral TA. Severity of melasma was assessed after 4th, 8th and 12th weeks after combination treatment using mMASI score. Results: Present study mean age affected 43.2+/-5.4 years, predominantly affected were females (75%). There is a significant difference in the severity of melasma between both groups at the...
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Posted by admin on Dec 31, 2023 in |
Video games can be symbolized as an escapism from the anxiety and pressure during the COVID-19 pandemic where social distancing is inevitable. Their growing popularity over the past decade has built the questions on how they might affect the physical health of the population. Our study aimed to determine the physical activity level with the frequency of exposure to video gaming among the pharmacy students during the pandemic. The cross-sectional study was conducted using an online survey consisting of a set of validated questionnaires modified from published literatures and the International Physical Activity Questionnaire (iPAQ) among the students at the Faculty of Pharmacy, Universiti Teknologi MARA. The survey was distributed to the students via e-mail and social network from April until June 2020 amid the Movement Control Order. A total of 314 sample were collected and majority of the respondents were females (55.1%) and Malay (96.5%). Our results showed that most students spent an average of 1 to 3 days per week playing video games (48.1%), with the frequency...
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