Posted by admin on Aug 31, 2023 in |
Parkinson’s disease (PD) is the second most prevalent type of neurodegenerative disorder and is a chronic, progressive condition. In the current investigation, we used a rotenone (ROT)-developing rat model of PD to assess the neuroprotective efficacy of ethanolic Withania somnifera root extract (EWSR) in comparison to the known neuroprotectants i.e., Doxycycline (Doxy), and ellagic acid (EA) individually and in combination (EWSR-Doxy-EA). Male Wistar rats were given ROT at a dose of 2.5 mg/kg body weight daily for 4 weeks to develop a PD in-vivo model. Once the PD model is confirmed, the rats were treated with individual neuroprotectants for next 5 weeks and kept under observation for next 7 days for reversal of PD. ROT administration has altered behavioural parameters (Cognitive, motor dysfunction, sniffing, grooming, raring, crossing, etc.) and neurotransmitter profile (Acetylcholine, epinephrine, nor-epinephrine, dopamine, glutamate and aspartate) in rats. The administration of neuroprotectants has ameliorated the deleterious effects of rotenone and restored cognitive and motor control by rectifying the levels of neurotransmitters which are responsible for the functions....
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Posted by admin on Aug 31, 2023 in |
Objective: The study’s key objective is to evaluate the Antidiabetic activity of methanolic root extract of Daucus carota in normal, streptozotocin-induced Diabetic, and alloxan-induced diabetic rats. Materials and Methods: Albino Wistar rats were administered at a dose of streptozotocin 50mg/kg /day and alloxan monohydrate 150mg/kg/day i.p. for 30 days. Experimental rats were given Daucus carota root extract in two different doses of 200mg and 400mg/kg/day orally. Results: The Preliminary phytochemical investigation of Daucus carota shown that the presence of sterols, saponins, flavonoids, and triterpenoids. In this study, Daucus carota root extract was administered for 30 days and showed antidiabetic activity in STZ diabetic rats and alloxan-induced rats. Conclusion: The methanolic extract of Daucus carota roots also has potential antidiabetic activity in STZ-Nicotinamide diabetic rats. The extract also normalized the altered diabetic parameter viz. glycosylated hemoglobin, plasma cholesterol and glutathione. The decreased level of cholesterol indicates that the plant extract also has hypolipidemic...
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Posted by admin on Aug 31, 2023 in |
Effective treatment depends on early and successful disease detection. A timely, cost-effective diagnostic method is the principal part of the treatment plan. The invention of saliva-based microbial, immunologic, and molecular biomarkers offers novel opportunities to bypass the shortcomings of other methods by utilizing oral fluids to evaluate the condition of both healthy and diseased individuals. Periodontitis is a common oral disease characterized by inflammation, connective tissue breakdown & alveolar bone loss. One of the important features of inflammation is enzymes from different oral tissue. The aim of the study is to detect salivary & serum enzyme levels in patients with periodontitis. The aim of the present study was to evaluate salivary enzyme levels in patients with periodontitis. Our present study aims to assay the salivary Aspartate & Alanine Aminotransferase, Alkaline & Acid Phosphates levels in a patient with generalized periodontitis before & after treatment. Material & Method: A total of 212 participants, males & females, were selected. Group A comprised 106 healthy adults, and Group B 106 patients generalized...
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Posted by admin on Aug 31, 2023 in |
Diabetes mellitus is a challenging human disorder for medical researchers, and the patients suffering from it are from all age groups and countries. BSL-150 tablets is a polyherbal formulation used for the treatment of diabetes mellitus. It contains seeds of Syzygium cumini, bark of Tinospora cordifolia, leaves of Gymnema sylvestre and seeds of Phyllanthus emblica. These plants’ dried, powdered parts in the same quantities as marketed tablets were mixed to obtain the in-house formulation. The phytochemical analysis of the methanolic extracts of in-house and marketed samples showed presence of flavonoids, steroids, alkaloids, terpenoids, phenols, saponins and tannins. Berberine, an isoquinoline alkaloid, was identified in samples using HPTLC andn-Butanol: Ethyl acetate: Glacial acetic acid: Water (3:5:1:1) as mobile phaseon silica gel 60 F254 TLC plates. This led to the development of a validated standardization method using Berberine as a chemical marker, following the guidelines of USP and ICH. The Rf of Berberine was found to be 0.322 ± 0.010. In the calibration curve the linearity was found to be in...
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Posted by admin on Aug 31, 2023 in |
Aripiprazole is a biopharmaceutics classification system (BCS) II drug used to treat schizophrenia and bipolar disorders. A fast-dissolving tablet will be an appropriate drug delivery route in these conditions. Therefore, the objective of the work was to convert aripiprazole into a solid dispersion via a spray drying process and further present it as an oral fast-dissolving tablet for improving patient compliance. The solid dispersion of the drug in mannitol from solvent evaporation via spray-drying forms porous amorphous solid dispersions. The spray drying trials were optimized using a custom design approach via Design Expert software version 13. Oral fast-disintegrating tablets containing optimized solid dispersions were evaluated for tableting properties, in-vitro drug release profile, and pharmacokinetic profile compared to aripiprazole. The optimized solid dispersion exhibited a 2-fold increase in solubility compared to pure aripiprazole. The tablet disintegrated in 27.1± 1.1seconds. The in-vitro drug dissolution showed a four-fold increase in drug release profile compared to pure aripiprazole in one h. The pharmacokinetic profile observed a two-fold increase in the bioavailability of solid dispersion in comparison to...
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