Posted by admin on Jan 1, 2014 in |
This research evaluates patient satisfaction with the core and secondary attributes of hospital healthcare service, using two conventional methods, stated and derived importance explaining pros and cons related to each method. The study shows the significance of some of the core attributes and secondary attributes are recoverable equally well, regardless of the method. On the other hand, satisfaction obtained through some attributes diverges depending on the evaluation method. This variation is systematic and the reason for the variation is explained which provides the basis to researchers to employ both stated and derived methods for assessing the genuine measurement of satisfaction. Further article identifies the influence of demographics on satisfaction derived through core and secondary attributes and the relation between demographics and the type of hospital visited (i.e. govt. or private). Again the gap analysis and the correlation between satisfaction and recommendation provides better picture of opportunities or gaps live in hospital healthcare services and the directions to combat these gaps or exploit opportunities...
Read More
Posted by admin on Jan 1, 2014 in |
The present investigation was to prepare and evaluate bioadhesive vaginal gel containing clotrimazole loaded microspheres a novel delivery system for vaginal use. Bioadhesive gel was prepared by incorporating drug loaded microspheres using bioadhesive polymer carbopol 934. Microspheres were prepared by spray drying technique using Eudragit RS-100 and RL-100 polymers with different drug/polymer ratios. Microspheres were characterized by SEM, DSC, FT-IR and particle size analysis and evaluated for morphology, drug loading and in vitro drug release in simulated vaginal fluid. The FT-IR and DSC spectra revealed that there was no chemical interaction between drug and polymers used. SEM revealed that microspheres were spherical with a smooth surface morphology indicating that CTZ was well dispersed inside the carrier with a mean particle size ranging from 17 -58 μm. The in vitro drug release from formulation M1 to M6 was found to be 83.10% to 98.88% at the end of 12th h. Among various formulations M4 was found to have good control release pattern as it has shown 99% drug release in...
Read More
Posted by admin on Jan 1, 2014 in |
Objective: To evaluate the hypoglycemic activity of ethanolic extracts, of Convolvulus pluricaulis in normal and streptozocin-induced diabetic rats. Materials and Methods: Ethanolic extract of leaves of C. pluricaulis were orally tested at the dose of 400 mg/kg, 600 mg/kg & 800 mg/kg for hypoglycemic effect in normal and streptozocin-induced diabetic rats. In addition, changes in body weight, serum cholesterol, triglyceride and total protein levels, assessed in the ethanol extract-treated diabetic rats, were compared with diabetic control and normal animals. Results: 800 mg/kg of C. pluricaulis produced a significant reduction in fasting blood glucose levels in the normal and streptozocin-induced diabetic rats. Apart from 400 mg/kg, 600 mg/kg showed activity from day 14. Significant differences were observed in serum lipid profiles (cholesterol and triglyceride), serum protein, and changes in body weight by 800 mg/kg treated-diabetic animals, when compared with the diabetic control and normal animals. Conclusion: 800 mg/kg of C. pluricaulis exhibited significant antihyperglycemic activity in normal and streptozocin-induced diabetic rats. They also showed improvement in parameters like body weight...
Read More
Posted by admin on Jan 1, 2014 in |
The purpose of this research was to develop mouth dissolve tablets of Hydrochlorothiazide and Ramipril, were prepared by direct compression technique. Ramipril is an Angiotensin Converting Enzyme (ACE) inhibitor. It is an inactive prodrug that is converted to ramiprilat in the liver, the main site of activation, and kidneys. Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Sodium and Chlorine (Na+ and Cl-) reabsorption from the distal convoluted tubules in the kidneys. The tablets were prepared using microcrystalline cellulose and dicalcium phosphate as diluents along with three different levels of disintegrant. The superdisintegrant used in this study were CCS and Maize Starch. The tablets were evaluated for weight variation, hardness, friability, wetting time, water absorption ratio, disintegration time (DT) and dissolution study. Formulation prepared with 30% of CCS showed Disintegration time of 20seconds in vitro. Also the hardness, friability, dissolution rate of prepared tablets (batch F4) was found to be acceptable according to standard...
Read More
Posted by admin on Jan 1, 2014 in |
Fluoride (F) is highly electronegative anion with cumulative toxic effects, from prolonged ingestion that can lead to the pathogenesis known as fluorosis, a condition especially persistent in third world countries, where populations have little choice as to the main source of F-contaminated drinking. In recent times many neurological problems among children are being addressed in endemic areas. Thereby reasons for the neurotoxicity have to be explicated thoroughly. In this study premated Wistar albino rats were exposed to 50 and 150 ppm fluoride in drinking water during gestation and pups born to them were used to analyze the extent of neurotoxicity imposed in discrete brain areas. Dose dependent toxicity was evident in different brain regions and fluoride exposure has significantly enhanced the levels of malondialdehyde (P>0.05), glutathione (P>0.05) and decreased the activities of superoxide dismutase (P>0.05), catalase (P>0.05), glutathione peroxidase (P>0.05) and glutathione- S-transferase (P>0.05). Alterations were region specific and oral supplementation of dietary antioxidants viz., vitamin-C (20mg), vitamin-E (400mg), zinc (200mg) and selenium (40mg) not only inhibited oxidative stress...
Read More
