Posted by admin on Jul 31, 2023 in |
Dendrocnide sinuate (Blume) has been widely used in the treatment of various diseases. The plant Dendrocnide sinuate (Blume) belonging to the family Urticaceae. Many indigenous peoples used this herb to treat swelling, fever, and urinary disorders. The karbis tribes also used it as a hypersensitivity therapy. The Bodo people of Assam gather the flowers of Dendrocnide sinuata (blume) and use them as a portion of food with fish. The plant extract was subjected to a preliminary phytochemical analysis, which revealed the presence of carbohydrate, tannin, flavanoid, phenol, terpenoids, cardiac glycoside, alkaloid. As part of the investigation on the mechanism of the anti-inflammation activity, plant extract’s ability to stabilize human red blood cells membrane was studied. It was effective in the stabilization of the human red blood cells membrane. Maximum stabilization of 65.03% was observed at 150µg/ml. Diclofenac, a standard anti-inflammation drug, showed a maximum stabilization of 54.08% at 150 µg/ml concentration compared with...
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Posted by admin on Jul 31, 2023 in |
Catharanthus roseus (periwinkle) is a medicinal plant that belongs to the Apocynaceae family. All parts of this plant are used as medicine according to ancient medicinal systems. In this research paper, plant leaf samples undergo phytochemical investigation through gas chromatography-mass spectrometry (GC-MS). As the result of GC-MS spectra we identified twenty-three phytochemical compounds in methanolic extract of C. roseus leaves. The identification of phytochemical compounds is based on the peak area, retention time, molecular weight and molecular formula. Compounds present to a major extent are specified with their NMR, IR, and Mass spectrometry data. This spectral analysis helps in the discovery of novel phytochemicals in the plant extract of this plant. We can guess about any novel phytochemicals that can be further used as synthetic units in organic synthesis reactions because natural synthetic units used in any process will always be environmentally friendly and follow green chemistry...
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Posted by admin on Jul 31, 2023 in |
A new simple High-Performance Thin Layer Chromato-graphic (HPTLC) method for determining Paracetamol, Diclofenac and Caffeine in combined tablet dosage form has been developed and validated. The mobile phase selected was Ethyl acetate: Methanol: ammonia (8: 2:0.1 v/v/v) with UV detection at 263 nm. The retention factor for Paracetamol, Diclofenac, and caffeine was found to be 0.639 ± 0.018, 0.267 ± 0.026, and 0.447 ± 0.026, respectively. The method was validated with respect to linearity, accuracy, precision and robustness as per the International Conference on Harmonization (ICH) guidelines. Results were found to be linear in the concentration range of 1000-6000 ng/band for Paracetamol 200-1200 ng/band for Diclofenac and 100-600 ng/band for caffeine, respectively. The method has been successfully applied to analyze drugs in pharmaceutical formulation. The % assay (Mean ± S.D.) was found to be 98.64 ± 0.184 for paracetamol, 97.17± 1.074 for Diclofenac and 98.27± 0.86 caffeine. The method can be used for routine analysis of these drugs in combined tablet dosage forms in quality-control...
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Posted by admin on Jul 31, 2023 in |
The advent of new diseases and the subsequent outbreak of the Covid-19 pandemic has resulted in a tremendous increase in both the production and consumption of antibiotics. While this has helped the economy expand, it has also led to the rise of a problem known as antibiotic resistance. Scientists and researchers worldwide are worried about the spread of antibiotic resistance among various bacterial species. Treating ailments brought on by bacteria resistant to antibiotics is possible through phage treatment. Although phage therapy has shown promise in treating several diseases, it is currently hindered by several obstacles that make widespread use of the technique problematic. We analyze an online survey’s results to better understand the prevalence of antibiotic resistance and phage therapy in human practice and the benefits and downsides of utilizing phages to combat pathogenic...
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Posted by admin on Jul 31, 2023 in |
One of the main causes of mortality around the globe is cancer. Cell division routes increase as cancer progresses, but planned cell death decreases. As a result, cancer is characterized by a variety of these failing systems. The present study used an in-silico approach to examine the ability of sesquiterpene lactones to inhibit the anti-apoptotic proteins Bcl-2 and Bcl-xl. Numerous Bcl-2 inhibitors are undergoing clinical studies. Using PyRx AutodockVina, the phytocompounds were further examined for their in-silico docking interactions. It is interesting to develop novel Bcl-2 inhibitors from phytocompounds such as Arctigenin, Arteminolide C, Gaillardin, Helenalin, and Ixerin D, which have binding affinity scores similar to obatoclax. Potential binding mechanisms within the receptor’s active sites were explored using molecular docking studies of all active substances into the binding sites of Bcl-2 and Bcl-xl, and the physiochemical properties of the phytocompounds were predicted according to Lipinski’s rule of...
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