Posted by admin on Dec 1, 2013 in |
A high-performance liquid chromatography (HPLC) method has been developed for the determination of isosorbide mononitrate and its related substances in isosorbide mononitrate and sodium chloride injection. An C18 column (5μm, 250 ×4.6 mm) was used for the determination, with methanol and water (25:75,v/v)as the mobile phase at the flow rate of 1 mL min−1. The detection wavelength was 210 nm. The related substances were quantitated versus an external standard. The method was capable of resolving all of the two known related substances. The two related substances were isosorbide dinitrate (ISDN) and 2- isosorbide mononitrate (2-ISMN), respectively. The method was successfully applied to quantify related substances. The limits of detection of isosorbide mononitrate, isosorbide dinitrate and 2-isosorbide mononitrate (2-ISMN) were all 0.3ng. And the limits of quantitation of isosorbide mononitrate, isosorbide dinitrate and 2- isosorbide mononitrate (2-ISMN) were all 0.8ng. The method was found to be accurate, precise, specific, linear and sensitive, for the...
Read More
Posted by admin on Dec 1, 2013 in |
The investigation on the local knowledge about traditional herbal medicine is becoming increasingly important in defining strategies and actions for conservation of medicinal plants. This study therefore considered worthwhile to collect information from local rural and tribal population living in Betul district of Madhya Pradesh (India) concerning the use of medicinal plants; identify the most important species used; determine the relative importance of the species surveyed and calculate the informant consensus factor (ICF) in relation to medicinal plant use. Data collection relied predominantly on qualitative tools to record the interviewee’s personal information and topics related to the medicinal use of specific plants. The present study revealed that 119 plant species grown in the study region are in use by rural and tribal community in traditional medicine for the treatment of various diseases. Most of the locals interviewed dealt with well-known safe medicinal plants such as, Allium sativum, Acacia arabica, Emblica offficinalis, Momordica charantia and Ocimum sanctum with use value of 0.62, 0.54, 0.52, 0.51, and 0.50 respectively. Dental, inflammation-pain...
Read More
Posted by admin on Dec 1, 2013 in |
Depression is a well-defined mood disorder which is characterized by state of disposition of mind and dislike or antipathy to activity that can affect an individual’s thoughts, demeanor, sense of emotional touch and physical well- being. Depressed people may feel mournful, troubled, uneasy in mind, meaningless, helpless and unworthy, experiencing as if having committed an offence. They are easily annoyed and disinclined to rest. It is a very important public health problem which is devastating millions of life all over world and making the scenario very look very pathetic. Homoeopathic medicines are effective in the treatment of various acute and chronic diseases. Efficacy of homoeopathic medicines on depression is of great importance. Most mental health disorders like depression, anxiety tend to chronic illness that requires long-term treatment. Appropriate treatment of depression with homoeopathic remedies can help to prevent the likelihood of serious recurrences of depression. The advantages of homeopathic remedies are-it is effective in people of all age right from children to the elderly, is safe and has minimal...
Read More
Posted by admin on Dec 1, 2013 in |
Salbutamol sulphate (SS) loaded microspheres were prepared by solvent evaporation method with combination of Sterculia foetida gum in various proportions. A total of eighteen formulations were prepared in different oil phases i.e., liquid paraffin and sunflower oil. Those prepared from liquid paraffin L1-L9 and those prepared from sunflower oil were S1-S9. Based on the particle size, entrapment efficiency, drug content,% yield, swelling index, % moisture loss, micromeritic properties batches prepared from sunflower oil showed better results as compared to those microspheres prepared from liquid paraffin. Thus, sunflower oil batches were optimized for further evaluation parameters. From further parameters four formulations were selected i.e., S2, S6, S8, S9. It was confirmed with the results of micromeritic property that all the selected formulations showed good flow property. Release data were analyzed based on best fitting models and all the optimized batches showed good fit to first order, Higuchi kinetics and Korsemeyer-Peppas. Stability studies showed almost negligible changes in particle size, drug content and drug release throughout the study ...
Read More
Posted by admin on Dec 1, 2013 in |
The whole plant of Spermacoce hispida L is reported to have great medicinal value.It is found effective systemically in treating, headache, constipation, anti-hypertensive, anti-fertility, Appetite, Scabies, Irritant bowel syndrome and skin disease etc. Intake of 2 to 4 g of the seeds along with a mixture of dry ginger, coriander seed andfinger millet reduces the unwanted cholesterol namely LDL and HDL from the body. Traditionally roots, leaves and stem of the Spermacoce hispida L are used as anti-eczema, antibacterial and cardio-vascular disorder, etc. Recently it is found that this herb contains Calcium and Phosphorus in the abundance hence administration of this drug in form of chooranam or kudineer (decoction) is recommended in conditions like bone diseases, fractures etc The present investigation was therefore undertaken to evaluate the requisite phytochemical screening andthe constipation activity of Spermacoce hispida by using albino Wistar rats. Phytochemical analysis was carried out with different chemical reagents.Constipation activity of Spermacoce hispida was analyzed by using albino Wistar rats.To cure the irritant bowel syndrome using the whole...
Read More
