Posted by admin on Oct 1, 2013 in |
A simple, accurate and rugged stability indicating UV Spectrophotometric method was developed using methanol as the solvent to determine Rizatriptan Benzoate content in pharmaceutical dosage forms. The UV Spectrophotometric method for Rizatriptan Benzoate was determined at λmax 278nm and the drug proved linear in the range of 10-80μg/ml, with a good correlation coefficient of 0.9997. Percentage purity was found to be 99.94% and an excellent mean recovery (98.65%-100.7%). The method was validated statistically and it can be employed for the routine analysis of Rizatriptan benzoate in marketed...
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Posted by admin on Oct 1, 2013 in |
The objective of the present study was to investigate anti-diabetic and nephroprotective and cardioprotective activity of Xylia dolabriformis leaves extract, using High Fructoseinduced diabetic C57BL/6Job/ob mice as model for clinical type-2 diabetic. At a regular interval of an experimental protocol blood glucose, urinary creatinine, total proteins, insulin resistance, total β-cell count, LDL, HDL,VLDL and organs to body weight ratio were studied. The histo-pathological study was carried out by High Fructoseinduced diabetic and anti-diabetic rats pancreas. Statistical analysis of the results shown that in High Fructoseinduced diabetic rats chloroform and alcohol extracts of Xylia dolabriformis leaves at 40, 80, 160 and 200 mg/kg doses. Xylia dolabriformis leaves extract improved renal creatinine clearance, decreased the LDL, VLDL, increased the HDL and reduce renal total protein loss demonstrating nephroprotective and cardioprotective properties. The organ to body weight ratio studies carried out on last day, shown pancreas and liver specific effects of Xylia dolabriformis leaves. These results were also supported by histo-pathological studies. We conclude from the present study that Xylia dolabriformis alcoholic...
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Posted by admin on Oct 1, 2013 in |
The present study has investigated the hypoglycaemic effect of oral administration of 50% ethanolic leaf extract of G. hirsutum Wight & Arn in normal and Streptozotocin–induced diabetic rats. Albino Wistar rats (190 to 220 gm) were induced diabetic condition by administration of Streptozotocin (STZ) (55 mg/kg bw) intraperitoneally. 50% ethanolic extract of G. hirsutum Wight & Arn leaves (300 mg/kg bw /day) was orally administrated to normal and STZ–induced diabetic rats (150, 300 and 450 mg/kg bw /day) for 30 days to determine hypoglycaemic and antihyperglycaemic activity. Serum and tissue biochemical analysis including fasting blood sugar level in normal and STZ–induced diabetic rats were investigated. Oral administration of 50% ethanolic extract of G. hirsutum Wight & Arn leaves (300 and 450 mg/kg bw/day) for 30 days exhibited a significant (p<0.05) reduction in serum Glucose (88%), Total Cholesterol (80%), Triglycerides (76%), HbA1c (75%) and in an oxidative stress. The findings of investigation showed similar to those produced by Glibenclamide (GB) at dose of 600 mg/kg bw /day for 30days (positive...
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Posted by admin on Oct 1, 2013 in |
In the present studies, antibacterial studies and medicinal effects of the ethanolic extract of Adhatoda vasica on the physiological variations including blood countvariations w.r.t. RBC, WBC, Hb and enzyme SOD activity of the subjects under study, Swiss Albino mice, on exposure to gamma radiations, have been evaluated. Phyto-chemical analysis of A. vasica showed the presence of alkaloids, saponins, tannins and reducing sugars. It was observed that RBC, WBC and Hb count of the control group mice increased with the administration of extract where as these parameters decrease on exposure to gamma radiations. However, in case of group of mice administered with the dose of the extract and exposed to gamma radiations, the decrease is much less as that observed in the mice exposed to only radiations. In case of enzymatic SOD activity, it was observed that the animals with extract dose showed lower value of SOD specific activity while the animals with extract dose and γ radiations also showed lower SOD specific activity as compared to the animals exposed...
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Posted by admin on Oct 1, 2013 in |
Standardization of herbal formulation is essential in order to assess the quality of drugs for therapeutic value. The present work is an attempt to standardize ‘Bhunimbadi Churna’, an Ayurvedic polyherbal formulation, used in fever and diabetics etc. The various parameters performed included organoleptic characteristics, physico-chemical parameter, physical characteristics of Churna, preliminary phytochemical, Heavy metal and Microbial analysis and high performance thin layer chromatography (HPTLC) analysis. The results obtained may be considered as tools for assistance to the regulatory authorities, scientific organizations and manufacturers for developing standard formulation of great...
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