Posted by admin on Aug 31, 2023 in |
Topical medications are frequently used to treat skin conditions. Antibiotic-resistant bacteria have emerged. As a result, the man has looked to nature for healing. Traditional medicines work better because they are less likely to cause side effects and are more effective. The Cocculu shirsutus and Tridax procumbens leaves were authenticated, dried, and extracted. Phytochemical screening and physicochemical analysis of extracts were done. The antimicrobial studies and in-vitro anti-inflammatory activity of extracts were carried out. The polyherbal gel was formulated by varying the concentrations of the gelling agents. The formulation was evaluated for physical appearance, visual homogeneity, pH, viscosity, and accelerated stability studies. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The F4 formulation showed the best results. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The best results were shown by F4...
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Posted by admin on Aug 31, 2023 in |
Urinary tract infection (UTI) is one of the most common infections affecting humans and is one of the leading causes of both community-acquired and nosocomial infections. The study’s objective was to assess the rate of de-escalation and the impact of de-escalation on cost and length of stay, antibiotics utilization pattern, and adverse effects of antibiotics in bacteremic UTI. A prospective observational study was conducted on 218 UTI patients in a tertiary care hospital in Trivandrum for 6 months. The results showed that the incidence of UTI is higher in females. The most common symptom was identified as fever, followed by dysuria. Escherichia Coli was the causative organism in most of cases. Inj. Cefoperazone and Sulbactum was the most frequently prescribed antibiotic. Gastric irritation was experienced by 1.8% of patients followed by exanthema in 0.5% patients. The rate of successful de-escalation was 26.9% while 73.1% failed de-escalation. A significant association (p-value < 0.001) was found between de-escalation failure and length of stay. According to our study, the absence of de-escalation...
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Posted by admin on Aug 31, 2023 in |
The PI3K-AKT-mTOR signaling pathway is widely used in cancer therapy as it is a signaling pathway that is frequently disrupted in human cancers. Increasingly, inhibitors develop against key proteins in signaling pathways, such as PI3K and mTOR. Dual inhibitors targeting PI3K and mTOR are more potent than one inhibitor targeting only a single protein. This study used to design and molecular docking analysis to investigate the precise binding positions and interaction forces of quinoxaline-containing compounds within the active site of PI3Kγ and mTOR with the help of freely available software for virtual screening of compounds, docking, and drug interaction result analysis. And also proposed the development of new potent drug candidates which works as dual inhibitors against cancer diseases; thus it could be concluded that Quinoxaline-containing derivatives might be used as a template for destiny improvement thru change or derivatization to lay out stronger healing...
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Posted by admin on Aug 31, 2023 in |
Pseudomonas aeruginosa is a Gram-negative pathogenic bacterium that can cause a variety of hospital-acquired diseases. It is a multidrug-resistant bacterium and can survive a wide range of antibiotics; hence there is a concern about its limited therapy options. In this scenario, the discovery and development of novel antibiotics are in high demand. In our research work, molecular docking a Bioinformatics technique, is applied to find the ideal lead molecule from plants. For this study, we have extracted literature-proven phytocompounds from a variety of traditional medicinal plants and their structures were retrieved from the PubChem database. Lipinski and ADME/TOX screening were used to evaluate drug likeliness, followed by docking against the target protein. Pseudomonas aeruginosa elastase, or LasB is a virulence protease that hydrolyzes host tissue and is thus considered the target protein. Elastase degrades human skin extracellular protein in wound infections, including tissue damage and inflammation. Thus, elastase could be a promising target for the discovery of novel lead compounds. As a result of docking studies, Eupalitin 3-o-galactoside, a...
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Posted by admin on Aug 31, 2023 in |
Among different neoplastic lesions, hepatocellular carcinoma plays a pivotal role due to the extreme difficulty of treating it in advanced conditions. Research shows that there is a high intractability towards chemotherapy for this disease. Therefore, using medicinal plants can be another approach to fend off this grim scenario and pave a new way to prolong survival time. For this purpose, the ethanolic extracts of leaves and fruits of Cassia fistula (Golden shower) as a probable anticancer drug have been administered in the liver cancer cell line, HEPG2 and the gene expression of cytokines (interleukin-6, interleukin-8, interleukin IL-1β, transforming growth factor-TGF-β1, tumour necrosis factor-TNF-α) against this treatment has been analyzed in the present work. The current study revealed a significant reduction in the expression of pro-inflammatory cytokines by the application of these extracts demonstrating their vital role in suppressing tumour growth and proliferation in liver cancer. It appears that important phytochemicals played a key role in decreasing the expression of these cytokines. The combination of leaves and fruit extracts of Cassia fistula can be...
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