Posted by admin on Oct 31, 2023 in |
Introduction: Monoherbal or polyherbal formulation, which is used in Siddha medication, have a wide variety of phytochemical substances as primary and secondary metabolites, which show many pharmacological activities, including the anti-inflammatory effect. Materials and Methods: The anti-inflammatory activity of Kanduparangi chooranam (KC) was evaluated by using carrageenan-induced paw edema and carrageenan-induced pleurisy Wistar albino rat models. KCwas administered orally at doses such as 100 and 200 mg/kg BW, and it was compared with the standard drug indomethacin (10 mg/kg, body weight). The changes in % of inhibition of paw volume, level of pleural exudates and migratory leukocyte count were noted. Results: In the carrageenan-induced rat paw oedema model, the test drug KC was found to be the paw oedema volume at the dose of 100mg and 200 mg/kg, body weight was 61.94% and 63.05 %, respectively (p<0.001) whereas Indomethacin which had 65.83% paw volume inhibition. In the carrageenan-induced pleurisy rat models, the test drug KC was found to be values of the pleural exudates level at the dose of...
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Posted by admin on Oct 31, 2023 in |
Raphanus sativus L, belongs to the family Brassicaceae. Phytochemical analysis of its methanolic root extract revealed the presence of alkaloids, flavonoids, glycosides, tannin, phenolic compounds, triterpenoids and steroids. The antimicrobial activities and in-vitro Pharmacological activities like Antioxidant Activity and Anti-inflammatory activity of the root extract was assessed. Production of reactive oxygen species (ROS) causes various diseases and cellular anomalies in human beings. Antioxidants inhibit generation of reactive species, or scavenge them, or raise the levels of endogenous antioxidant defenses. In this study the radical scavenging ability different extracts of Raphanus sativus L. was undertaken. Results revealed that the root of Raphanus sativus L. has potent antioxidant ability. A good correlation was found to exist between concentration of extract and % inhibition of protein denaturation and free radicle damage. From different literature reports, root extract was found to be more potent antioxidant than the other parts of the plant. The extract had shown significant anti-bacterial activity against bacterium like Lactobacillus, Streptococcus aureus, Escherichia coli against standard Tetracycline by the determination...
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Posted by admin on Oct 31, 2023 in |
It appears that you have conducted a study on the preparation of Glipizide sustained-release tablets using different HPMC (hydroxypropyl methylcellulose) polymers of varying viscosity grades, specifically HPMCK 4M and HPMC K 15M, in different proportions. The concentration of the polymers was optimized using a simplex mixture design, with HPMC K4M, HPMC K15M and lactose as the components of the mixture. The tablets were prepared using the wet granulation method. According to your study, the prepared tablets exhibited polymeric synergism, which was confirmed through in-vitro dissolution testing. Both HPMC K4M and HPMC K15M showed a synergistic effect on the T50% drug release. However, HPMC K15M demonstrated a dominant effect compared to HPMC K4M due to its higher viscosity. It seems that the higher viscosity of HPMC K15M contributed to a more sustained drug release profile in the tablets. This finding suggests that HPMC K15M played a more significant role in controlling the release rate of Glipizide from the tablets, as compared to HPMC...
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Posted by admin on Oct 31, 2023 in |
Objectives: Fragmented micronucleus is a good prognostic indicator for monitoring and detecting chromosomal / genetic damage in human population. The objective of this study was to count the cells with presence of micronucleus in cervical pap smears in women with reproductive age group and to detect its predictive value. To substantiate the importance of Micronucleus evaluation in routine Pap smears evaluation for cervical cancer screening. Material and Method: In this study 750 cases, consisting of 200 smears of normal study, 200 smears of infective pathology with trichomonas, bacterial vaginosis and candida infection, 100 smears of ASCUS & ASC-H, 200 smears of squamous intraepithelial lesion (LSIL-100 & HSIL-100 ) and 50 smears of invasive carcinoma of women in reproductive women of age group were studied. The cervical smears of women with 20-45 years of age were included in the study. The study was conducted from Jan 2022 – Dec 2022 at Srinivasan Medical College and Hospital, Samayapuram, Trichy. Only routine papanicolaou-stained cervical smears were used. In each smear, the number...
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Posted by admin on Oct 31, 2023 in |
The aim of this study was to evaluate the antimicrobial and antibiofilm activity of silver nanoparticles of Azadirachta indica (AISNPs) against the pathogens isolated from effluent. Green synthesis approach was opted for the synthesis of the synthesis of AISNPs by using the ethanolic extract of Azadirachta indica which was added to 1mM solution of AgNO3. These synthesized nanoparticles were molecularly characterized by UV-Visible spectrophotometer, TEM, Zeta Sizer, Zeta Potential, XRD and FTIR respectively. Antimicrobial activity of the AISNPs was carried by well diffusion method on Muller Hinton Agar against biofilm-producing multi-drug resistant effluent pathogens, which were identified as E. coli, P. aeruginosa, S. aureus and K. pneumoniae. The zone of inhibition of AISNPs observed in case of E. coli was 16.08 mm, 18.65 mm against S. aureus, 10.46 mm against P. aeruginosa and 15.34 mm against K. pneumoniae. Antibiofilm activity of AISNPs demonstrated the decline of biofilm producing activity by 76% against P. aeruginosa, 74% against S. aureus, 60% against K. pneumoniae and 59% against E. coli respectively, indicating...
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