Posted by admin on Aug 31, 2023 in |
The development of Nanotechnology has paved the way to study various nanomaterials. Nanoparticles are structures that measure the size from 1-100nm. Widely used nanoparticles are usually prepared using noble metals, that is, gold, silver, palladium, and platinum. At the same time, they find their way into a wide range of applications in medicine, electronics, energy saving, environment, textile, cosmetics, biomedical, etc. The natural reducing agents in plants, such as carbohydrates, flavonoids, etc., reduce the silver, generating potential silver nanoparticles. Silver nanoparticles are intended to be used for the present study generated through green synthesis using millets. Millets are small-seeded grasses that are hardy and grow well in dry zones as rain-fed crops under marginal conditions of soil fertility and moisture. The different varieties of millets intended to be used in the project are Barnyard millet, Finger millet, Foxtail millet, Kodo millet, little millet, Pearl millet, Prosomillet, Sorghum. The Silver nanoparticles synthesized through an aqueous extract of different varieties were checked for their quality using UV-VIS spectrophotometer and Scanning electron...
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Posted by admin on Aug 31, 2023 in |
An example of the human microbiota is Staphylococcus saprophyticus, a gram-positive, non-hemolytic pathogenic bacterium. It’s a prevalent culprit behind simple infections associated with the urinary tract, especially among sexually active young women. It has a high colonization rate in the perineum, rectum, urethra, cervix, and gastrointestinal system and is also quite lethal. Because of their ability to form a biofilm, these bacteria are highly resistant to antibiotics. Thus, unconventional methods, such as the use of silver nanoparticles, have been devised to counteract this type of biofilm. The silver nanoparticles are produced in an environmentally friendly way by utilizing an extract of water from banana peels. UV/Vis, FTIR, SEM, and EDAX are the four methods used to characterize the NPs and validate their production. Using the Screening method and SEM analysis, we show that silver nanoparticles inhibit the growth of Staphylococcus saprophyticus ATCC 15305, the most prevalent bacteria responsible for urinary tract infections....
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Posted by admin on Aug 31, 2023 in |
Background: Prescription audit is an effective way to raise the standard of prescriptions. WHO core prescribing indicators are established and trustworthy tool for assessing the quality of prescriptions. So, we used WHO-recommended core prescribing indicators to assess the prescription pattern of treating physicians. Methods: A retrospective observational study was done. A total of 632 prescriptions were included with 2002 drugs from general medicine OPD. The prescriptions were analyzed for general details, legibility, rationality, and WHO core prescribing indicators. The data obtained were presented as descriptive statistics by using MS-Excel and SPSS ver.24. Results: All the prescriptions had general details mentioned as pre-printed. The average number of drugs per encounter was 3.17 ± 1.64 and only 461 (23.03 %) of the drugs were prescribed by generic name. The percentage of encounters prescribed with an antibiotic 160 (25.3%) and an injection 164 (25.9%) was observed. A total 1767 out of 2002 (88.3%) of the drugs were prescribed by the NLEM. Prescriptions with diagnosis (77%), signed (83.07%), and 61.07% with legible handwriting...
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Posted by admin on Aug 31, 2023 in |
D5 Chooranam is a classical Siddha formulation developed by Central Council for Research in Siddha, prescribed for the management of diabetes mellitus. The present work was carried out to assess phytochemical profile and also to explore the antioxidant potential of Siddha drug D5 Chooranam. The Phytochemical profile and antioxidant activity were evaluated in five different solvent extracts (Ethyl acetate, chloroform, ethanol, petroleum ether, and water) of D5 Chooranam. The phytochemical analysis of D5 Chooranam disclosed the existence of various phytochemicals in D5 Chooranam. The amount of phytochemicals present in D5 Chooranam also correlates with the various pharmacological activities as per its therapeutic indications. The considerable radical scavenging capacity of D5 Chooranam, particularly in its water extract, ethyl acetate extract, and fresh aqueous solution, is well justified by the results of all in-vitro antioxidant studies. These results reveal the beneficial effect of D5 Chooranam against oxidative stress associated disorders like diabetes mellitus and its complications. Hence it can be concluded that it may be due to the presence of vital...
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Posted by admin on Aug 31, 2023 in |
Introduction: Bacterial infections are associated with significant morbidity and mortality globally. This scenario is further complicated by the development of antibiotic resistance, which has an adverse impact on the world economy by increasing the treatment cost and prolonging the hospital stay. It also requires use of reserve antibiotics which have higher toxicity. Hence, new antibacterial drugs are urgently needed to combat multidrug-resistant organisms. The present study was designed to synthesize novel 1-(pyridine-2yl)-1H-pyrazole-5-Carboxamide derivatives and to screen them for antibacterial activity. Methods: A simple, multistep procedure was used to synthesize novel 1-(pyridine-2yl)-1H-pyrazole-5-Carboxamide derivatives. They were characterized by LCMS and NMR. Their antibacterial activity was evaluated against four bacterial strains namely E. coli, Pseudomonas aeruginosa, Bacillus cereus and Proteus mirabilis by agar well diffusion method. Ciprofloxacin was used as the reference standard. Results: Nine novel 1-(pyridine-2yl)-1H-pyrazole-5-Carboxamide derivatives (8a-8i) were synthesized by a cost-effective procedure. The yield of the compounds was good, ranging from 73% to 85%. Compounds 8b, 8h and 8i showed moderate activity against E coli, compound 8g against Bacillus...
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