Posted by admin on Oct 31, 2023 in |
Clitoria ternatea was selected because it possesses various medicinal compounds of great significance based on its usage as an ayurvedic drug to cure various diseases. This study helps to understand the significance of plant sources that possess pharmacological activities and is good for health on regular consumption. A comparative study was thus conducted to analyze the potential antioxidant activity by experimental quantifying the certain bioactive compounds present in the aqueous and methanolic extracts of the fresh and dry flowers of the blue flowered variety of Clitoria ternatea. This study showed that all the extracts possessed desirable antioxidant activity examined by DPPH assay and peroxide value assessment due to considerable amounts of secondary metabolites like flavonoids, phenols, steroids etc., determined quantitatively during the phytochemical analysis. Although the dry methanolic extract showed positive results overall during the phytochemical analysis, the fresh aqueous extract of C. ternatea showed the highest antioxidant property with 63.63% scavenging...
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Posted by admin on Oct 31, 2023 in |
In the past years many drug discoveries were investigated to be poorly soluble in aqueous medium. These poorly aqueous soluble drugs include Econazole Nitrate (ECZN) having high permeability. ECZN is an effective, potent anti-fungal drug used to cure large range of fungus. Oral administration of ECZN causes gastrointestinal irritation. To overcome or avoid the “first pass metabolism” and to optimise the drug concentration at the infected site of action topical gel was formulated, topical gels have better tendency to convey the drug via skin as compared to ointment, because gels are non-greasy and comfortable for application. To improve the solubility of ECZN in aqueous medium, Co-crystal technique was established to be a boon to the pharmaceutical industry. Crystalline structure of co-crystals consists of ECZN and Co-former either amino-acid or carboxylic-acid in equimolar ratio and penetration-enhancer was used. Liquid based grinding method used for fabrication of co-crystals. Formulated Co-crystal was incorporated in Carbomer-934 based topical gel. Characteristic peak was determined by Fourier transform infrared spectroscopy, the large number of particle size was...
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Posted by admin on Oct 31, 2023 in |
Chrysanthemum morifolium is commonly known as chrysanthemum. It has been widely used in traditional medicine due to its various therapeutic effects. Past studies have shown that chrysanthemum extracts possess significant anticancer activity against breast, prostate, and colon cancer cells. The active compounds in chrysanthemum extracts such as flavonoids, sesquiterpenes, and triterpenoids have been found to induce apoptosis (programmed cell death) in cancer cells, inhibit cell proliferation thus prevent cancer cell migration and invasion. Furthermore, chrysanthemum extracts have also been reported to enhance the efficacy of conventional chemotherapy and reduce its side effects. Based on the previous studies the present research has been aimed to determine the anticancer activity of petals of Chrysanthemum morifolium against Hep G2 liver cancer cells by evaluating the cytotoxic potential by MTT assay ((3-(4,5-dimethylthiazol-2-yl)-2,5- diphenyltetrazolium bromide) tetrazolium reduction assay), the study of apoptosis mechanism and cell cycle analysis by flow cytometry to understand the cell cycle changes in liver cancer cells when compared with Doxorubicin. The results obtained have demonstrated a prominent anticancer activity of...
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Posted by admin on Oct 31, 2023 in |
Isolation of plant-based pesticides gaining recent interest due to the clastogenic implications of synthetic insecticides. The polyphenolic-rich fraction from the stem bark of Streblus asper was proven as an insecticide against Dysdercus cingulatus. This study aims to evaluate the genotoxicity of polyphenolic bioinsecticide from Streblus asper (PBSA) using the mouse bone marrow micronucleus assay and compare its effect with malathion, an organophosphorus insecticide, and vepacide, a neem-based bioinsecticide. The micronucleus assay was conducted after 24 and 48 hours after the second administration of the pesticides (two doses by i.p. injection for two consecutive days). Swiss albino mice were divided into six groups, each comprising six animals. The first group received dimethyl sulphoxide (Group I – DMSO control), the second group (Group II – positive control) received 100mg cyclophosphamide/ Kg body weight, Group III received 276mg (LD10) malathion/ Kg body weight and Group IV received 1000mg (LD10) vepacide/ Kg body weight. Group V and VI received 500 and 1000mg polyphenolic-rich fraction (PBSA)/ Kg body weight respectively. A significantly higher frequency...
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Posted by admin on Sep 30, 2023 in |
The Box jelly fish Chiropsoides buitendijki (Horst R, 1907) were collected during low tides from Edwan village, of West Coast of Mumbai. Identification was done at the Central Marine Fisheries Research Institute (CMFRI), Mumbai. Crude extract of Chiropsoides buitendijki (Horst R, 1907) was obtained following the 80% methanol and 1%acetic acid, absolute methanol and n-butanol (1:1), and n-butanol. The antibacterial activity was carried out on bacteria E. coli, K. pneumonia, S. aureus, S. flexneri, V. Cholerae, C. sporogenes, S. enterica, E. faecalis, and fungal strain Candida albicans and Aspergillus niger whereas the antimycobacterial study was carried out on Mycobacterium tuberculosis (MTB) strain, H37 Rv: ATCC No- 27294. From the above study it is confirms that, the crude extract of Chiropsoides buitendijki have antibacterial and anti- tuberculosis...
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