Posted by admin on May 1, 2013 in |
Effervescent tablets or granules are uncoated and generally contain acidic substances and carbonate or bicarbonate which reacts rapidly to release carbon dioxide when dissolved in water. There are various advantages of effervescent formulations such as fast onset of action, good stomach tolerance, improves palatability, enhanced permeability, but a major problem which is associated with these formulations is their sodium content which is present in the form of sodium bicarbonate. According to various guidelines the per day sodium intake is advised to be limited by 2400 mg. This excess sodium would produce health complications particularly to cardiac and renal patients. The main objective of present work was to use a non-alkali carbonate to avoid the problems which may occur due to presence of alkali carbonates in effervescent preparations. Arginine carbonate was found to be a suitable carbonate source as it has an additional advantage of being an amino acid source. Arginine carbonate was produced in the laboratory by saturating the solution of arginine in DM water with carbon dioxide and...
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Posted by admin on May 1, 2013 in |
Aim: To evaluate anti-inflammatory effects of losartan in experimentally induced rheumatoid arthritis (RA). Materials and Methods: Adjuvant induced arthritis model is used in this study. Albino-Wistar rats of either sex were used. Arthritis was induced by single intra-plantar injection of Freund’s complete adjuvant (FCA) suspended in oil in right hind paw. Rats were divided in to three groups (n=8) namely disease control, standard and test group. Drug treatment was carried out for 21 days. Effect of test drug on acute inflammatory phase was evaluated on day 5 by assessing right hind paw edema. After 21 days animals were sacrificed and evaluated for left hind paw edema, weight changes, histo-pathological synovitis grading in left hind limbs and secondary lesion score. Results: Results showed that losartan significantly reduced right hind paw edema on day 5 (p<0.05) and showed significant weight gain (p<0.05). Losartan though reduced the histo-pathological synovitis grade and secondary lesion score was not statistically significant (p>0.05). Conclusion: Our study suggests that losartan could be a potential candidate for treatment...
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Posted by admin on May 1, 2013 in |
Oral controlled release pellet formulations of glipizide were prepared using extrusion spheronization technique. Pellets provide specific advantages in controlling the drug release and increasing the absorption of the active ingredient. The major drawback for these systems is dose dumping which is very prominent in presence of alcohol. In the present study, attempt was made to prepare alcohol resistant pellet formulations of glipizide. Glipizide is an oral anti-diabeticdrug belonging to the sulfonylurea group, used for the treatment of non-insulin dependent diabetes mellitus (NIDDM). Various polymers like Eudragit RSPO, RLPO and cellulose acetate butyrate were used for preparing the pellets. The prepared pellets were studied for different flow properties and drug release studies. The in vitro drug release studies were carried out in phosphate buffer as well as in phosphate buffer containing 5% alcohol. Drug release from the pellets was by non fickian diffusion mechanism and was comparable with that of marketed preparations. The pellets also had shown resistance to alcohol dose...
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Posted by admin on May 1, 2013 in |
The main objective of the present investigation is to evaluate the analgesic activity of ethanolic extract of Tamarindus indicaL. on mice. Analgesic activity of the ethanolic extract of the Tamarindus indica leaves at a dose of 200mg/kg & 400mg/kg was evaluated against the standard drug Diclofenac-Na at a dose of 25mg/kg. Adult Swiss albino mice of either sex of divided in to 4 groups comprising six numbers in each group was undertaken for study and evaluated by tail immersion method. The three doses of T. indicaleaves ethanolic extract was found to produce significant (p < 0.05) analgesic activity. In tail immersion method the crude extract produced elongation of time 30 minutes after oral dose of 200 and 400 mg/kg body weight respectively. 400 mg dose of Ethanolic extract of Tamarindus indica show analgesic activity comparable to 25mg Standard drug (Diclofenac sodium). 400mg Ethanolic extract of Tamarindus indica shows better result in comparable to standard drug. Ethanolic extract of Tamarindus indicaleaves have potential analgesic activity against stimuli in the tested...
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Posted by admin on May 1, 2013 in |
In the present study, novel derivatives of substituted cis-stilbene were prepared from benzyl (chloro) triphenyl phosphorane, substituted phenyl acetic acid and In vivo anti-inflammatory activity was evaluated by carrageenan- induced rat paw edema assay model. The newly synthesized compounds were characterized by IR, 1H NMR and Mass analyses. The results revealed that all the test compounds protected the rats from carrageenan induced inflammation and the test compounds showed a significant anti-inflammatory activity against the control group. Among the compounds tested 1i, 1l, 1o, 2c, 2d, 2h, 3b and 3d showed better anti-inflammatory activity and 2f, 3c showed moderate...
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