Posted by admin on May 1, 2013 in |
Background: Rational drug use in pregnancy requires the benefits and potential risk associated with the use of the drug. The adverse effect of drugs on the fetus varies temporarily with time. The fetus susceptibility to injury depends on its period of development of different organs have different critical periods through the span from gestational day 15 to day 60 is critical for many organs. Objective: To assess the pattern of drug use among pregnant women in Adama Referral Hospital, Oromia region, Ethiopia. Methods: All drug prescriptions of pregnant women prescribed from December 1, 2011 to May 30 2011 were reviewed retrospectively using structured data collection format. Result: A total of 381 pregnant women prescriptions were included in the study. The average maternal age in the study was 26.74 years. A total of 176(24.44%), 336(46.66%) and 208(28.88%) drugs with an average 2.2, 1.13 and 1.83 per pregnant women were used in first, second and third trimesters respectively. Minerals and vitamins 209(29%) were the most frequently prescribed drugs followed by Antibiotics...
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Posted by admin on May 1, 2013 in |
Two simple, precise and accurate methods were developed and validated for the Simultaneous estimation of Hydrocortisone acetate and Sulphacetamide sodium in the combined dosage forms. The first method involves the usage of Simultaneous equation for the determination and the second method employed is the Multicomponent mode. For both the methods the wavelengths selected were 241.5nm and 271.0nm which are the absorbance maxima of Hydrocortisone acetate and Sulphacetamide sodium respectively. The drugs obeyed Beer’s law in the concentration range of 5-50µg/mL for hydrocortisone acetate and 5-40 µg/mL for Sulphacetamide sodium. The results of the analysis were validated statistically and by recovery...
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Posted by admin on May 1, 2013 in |
The study aims at assessing Basil’s genetic phenotypic variability and viral disease incidence in India for sustainable pathological interventions. Basil (Ocimum basilicum) is important for its medicinal and nutritive value. It is highly adaptable as a potential crop in the tropics and could therefore enhance the food security of India nations. Germplasm seed evaluation and characterization was therefore carried out from the Research lab, D.B.S. College (R.L.D.B.S.C.) & F.F.D.C. seed collection survey to expand F.F.D.C. basil genetic base. The field layout was completely randomized design with five replications. The treatments were: O. basilicum, O. gratissimum and the local basil. Treatments were randomly allocated per replication. There were significant phenotypic differences in the O. basilicum variety. These differences were observed in the plant coloration ranging from deep to light purple coloration of stem, leaf, leaf vein and petiole. Our observations also revealed for the first time significant tolerance to Venial Mottle Mosaic Virus (VMMV) in the purple colored compared to the green O. basilicum in the early stages of growth...
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Posted by admin on May 1, 2013 in |
: The aim of the present study is to evaluate the cytotoxic effect of the ink extracts of different specis of cuttlefish (Sepia pharaonis female, Sepia pharaonis male, Sepiella inermis female, Sepia aculeata female) and squid (Loligo duvauceli female). The ink extracts were prepared by delipidation with acetone and extracted by Tris HCl buffer. The cytotoxic effect of the drug was studied using Trypan blue cell viability assay andethidium bromide /acridine orangestaining. The ink extracts from different species of squid and cuttlefish inhibited cell proliferation and induced cell death in a dose dependent manner. The cytotoxic effects induced by cuttlefish ink extract on chick embryo fibroblast cells involve typical apoptotic changes like nuclear condensation, studied using ethidium bromide and acridine orange staining. The ink extracts from the female Cuttlefish, Sepia pharaonis (25 and 75 µg/ml) showed the highest antiproliferative activity. The results suggested the potent antiproliferative effect of the ink of cuttlefish, Sepia pharaonis on chicken embryo fibroblasts and thereby the therapeutic potential of the ink as an anticancer...
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Posted by admin on May 1, 2013 in |
Background: In Ethiopia, study about prevalence and determinants of depression among adultadmitted patients is scanty. Depression in adults aged 18 years and older who also have physical health problem at hospital setting is high risk factor for psychiatric disorder. Objective: to assess prevalence of depression and determinants among adultpatients admitted in governmental hospitals, Mekelle, Tigray, Ethiopia, 2012. Methods: The study design was a hospital based cross-sectional study, data was collected from280 adult hospitalized patients using systematic random sampling technique and questionnaire standardized structured Hamilton depression rating scale was conducted from March 23, 2012 to April 21, 2012 study period. The data first was cleaned, edited, coded and entered into computer and analyzed using SPSS version 16.0. Frequency and other descriptive statistics were computed. Bivariate and multivariate logistic regressions was done for association, the test of odd ratio was using 95% confidence interval and P-value <0.05. Results: A total of 280 patients were interviewed study subjects thus made response rate of98.2%. Out of this 118 (42.1%) were males and 162...
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