Posted by admin on Aug 1, 2013 in |
The present study deals with the antioxidant activity, drug likeness score and bioactivity score of the compounds isolated from Curcuma longa and search lead antioxidant compound through molinspiration software. We have taken ten compounds from this plant. All the compounds were further subjected to molecular properties prediction and drug likeness by Molinspirstion and found in compliance with Lipinski’s rule of five. The compounds IV, V, IX, X fulfill Lipinski’s rule and show good drug likeness score. Milog P of these compounds was found below 5 that means these shows good permeability across cell membrane. TPSA below 160 Ǻ2, n violatios =1 or <0 it means compound easily bind to receptor, molecular mass <500, n rotb < 5 [10], Number of hydrogen bond donors ≤ 5 (The sum of OHs and NHs), Number of hydrogen bond acceptor ≤ 10 (The sum of Os and Ns). Compounds I-X were taken further calculation of bioactivity scoreby calculating the activity score of GPCR ligand, ion channel modulator, nuclear receptor legend, kinase inhibitor, protease...
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Posted by admin on Aug 1, 2013 in |
Olmesartan medoxomil (OLM) is an angiotensin II receptor blocker used for the treatment of hypertension. In this work an attempt was made to mask the metallic taste and enhance the solubility and dissolution rate of poorly soluble OLM by formulating it as inclusion complexes with β-cyclodextrins (β-CDs) as complexing agent in 1:1 molar ratio. The drug – CDs complexes were prepared by physical mixing and co-evaporation methods. The complex formation with in solid state was confirmed by Fourier transform infrared spectroscopy, x-ray diffractometry, differential scanning colorimetry and by scanning electron microscope analysis. From the prepared inclusion complexes, orodispersible tablets (ODTs) were formulated by using various superdisintegrants like sodium starch glycolate (SSG) and crospovidone in various concentrations (5-15%). Prepared tablets were evaluated for physical parameters and drug release by in vitro dissolution studies. ODTs containing SSG (15%) as super-disintegrant showed fastest disintegration and in vitro drug release. In conclusion, the present investigation demonstrates that the combination of inclusion complexation and using of superdisintegrants was a promising approach in the preparation...
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Posted by admin on Aug 1, 2013 in |
The main goal of this study was to develop a stable formulation of model antibacterial drug as an immediate- release tablet systematically using Quality by Design approach of which design of experiments is an integral part. The model drug was found to be a BCS class II drug official in USP having a plasma half-life of three to four hours. The formulation development work was initiated with wet granulation method and a total of three trials were conducted to determine the critical material attributes of the formulation used as factors for the experimental designs. The binder (Povidone K29/32,), Superdisintegrant (Crosscarmellose Sodium), Lubricant (Stearic acid and magnesium stearate), Pregelatinized Starch 1500 (binder and disintegrant) were determined to be critical for the formulation of the model antibacterial drug. A fractional factorial design (FFD) for four factors at two levels was selected to screen the varied response variable. A total of eight trials were conducted (24-1FFD).The four factors viz. Povidone K29/32(X1), Crosscarmellose Sodium (X2), lubricant ratio (X3) and Pregelatinised starch 1500 IG:EG...
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Posted by admin on Aug 1, 2013 in |
Atorvastatin Calcium, competitive inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-determining enzyme in cholesterol biosynthesis via the mevalonate pathway, thereby lowering cholesterol level in plasma of body. Oral bioavailability of Atorvastatin Calcium is very low (less than 4%), due to its poor water solubility. The aim of this investigation was to develop a microemulsion of Atorvastatin Calcium for enhancing its solubility, and its oral bioavailability. For this purpose, initially, solubility of Atorvastatin Calcium was determined in various vehicles. Oil, Surfactant and Cosurfactant were selected based on the solubility and HLB value. Pseudo-ternary phase diagrams were constructed to identify the microemulsion existing zone. Solubility study was also performed for optimization of formulation. The optimized microemulsion formulation was characterized for its % transmission, globule size, zeta potential, conductivity, % assay, and phase separation study. Globule size and zeta potential of the optimized microemulsion formulation were found to be 57.61 nm, and -19.4 mV, respectively. The viscosity and conductivity data indicated that the microemulsion was of the o/w type. Solubility of Atorvastatin...
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Posted by admin on Aug 1, 2013 in |
Depression can be termed as a state of mind where in the person has negative thoughts, pessimistic views of future and constantly in sad mood, he feels lonely to the extent that he may committing suicide. A decrease in serotonin and nor epinephrine level can cause depression and Dopamine plays an important role in regulating our drive to seek rewards and obtain a sense of pleasure. Music therapy is an emerging field to treat depression. Music brings changes in brain waves which in turn create alternations in bodily functions controlled by autonomic nervous system such as breathing and heart rate and slower breathing brings relaxation that is necessary to cure depression. The aims and objective of this study is to access efficacy of music therapy in reducing the symptoms of clinical depression and to compare the efficacy of antidepressant alone and music therapy in patients of depression. Music therapy is comparable to drug therapy in mild cases of depression but in moderate and severe cases there is negligible effect...
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