Posted by admin on Jun 30, 2023 in |
Antibiotic yield has been raised by numerous pharmaceutical firms in response to the rising population, the COVID-19 outbreak, and the introduction of several new diseases. Several heavy metals are used in the antibiotics’ formulation. The release of antibiotics and heavy metal ions has wreaked havoc on the ecosystem. The issue with heavy metals is that the bulk of them last a long time in the environment and are a leading cause of different types of cancer and other human diseases. On the other hand, experts worldwide are concerned about the presence of antibiotics in the environment, particularly in wastewater, because it leads to the emergence of antibiotic-resistant microorganisms (superbugs) that can cause widespread damage. Bioremediation is a viable approach for treating pharmaceutical industry wastewater with antibiotics and heavy metal ions. Copper, cadmium, nickel, zinc, lead and iron are common heavy metal ions found in wastewater from antibiotic-producing pharmaceutical firms. Along with it, antibiotics like chlortetracycline, oxytetracycline, cefalexin, Sulfamethoxazole, norfloxacin and ciprofloxacin are frequently found in the effluent of pharmaceutical...
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Posted by admin on Jun 30, 2023 in |
Introduction: The aim was this trial is to assess to evaluate the effect of “Chaturjatadi Sambharaka” in the management of malnutrition in Children. Material and methods: This research work was done in two phases. Phase one included demographic study and in phase two was clinical study. A Randomized open label-controlled trial was conducted on100 undernourished children of 1-10 years of age group. Total cases were divided into two groups (50 in each). In Group A, only Nutritional Rehabilitation (As per ICMR guidelines) was administered whereas in Group B, Nutritional Rehabilitation (As per ICMR guidelines) along with the trial drug Chaturjatadi Sambharaka was administered. The trial drug was administered in Avleha form in a dose 180-200 mg/kg/day in divided dose or 8 weeks and post follow up was done after month. Scoring of chief clinical features was done before and after treatment. Result: The clinical efficacy of the drug was analysed statistically on all parameters mentioned in the Assessment criteria. Both groups, showed statistically significant (P<0.001) improvement on anthropometric parameters-...
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Posted by admin on Jun 30, 2023 in |
Clove oil is an essential oil made from the plant, Szygium aromaticum. It is commonly used to help ease digestive issues, relieve pain, and support respiratory conditions. This work aims to determine at what temperature sublingual films are formed most effectively during process. The given temperature batches were manufactured at 75 °C, 80 °C, 85 °C, 90 °C. The sublingual films were prepared by using the solvent casting method, and the materials used, such as Hydroxypropyl methylcellulose E5, and different grades of polyox were previously optimized. The various batches at different temperatures went through characterization regarding the viscosity of the solution before casting as well as film weight and thickness after casting. All other samples used were of 21 mm x 25 mm film. With these given film samples from each batch, surface pH, swelling index, folding endurance, tensile strength, disintegration time, and percent moisture were all tested. Thus, this study showed the optimum temperature for fast-dissolving sublingual films of clove oil to improve bioavailability and ease of...
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Posted by admin on Jun 30, 2023 in |
The present study focuses on developing and validating a high-performance thin-layer chromatography (HPTLC) densitometry method for identifying and quantifying ellagic acid, glycyrrhizic acid and hesperidin in the ethanolic extract of Punica granatum, Glycyrrhizic glabra and Citrus sinensis. The separation was achieved by mobile phase for ellagic acid was Methanol: Water: Formic acid (3.8:4.7:0.8) and spotting was done on RP TLC Al plate silica gel 60, for glycyrrhizic acid was ethyl acetate: Formic acid: Glacial acetic acid: Water (14.7:0.8:0.5:1) and mobile phase for hesperidin was n – butanol: Acetic acid: Water (2.8:0.6:0.9) on TLC aluminium plate pre-coated with silica gel 60 F254. Densitometric scanning was carried out at a wavelength of 254nm and 287nm in absorbance mode. The peak corresponding to reference standard and that of the extract had the same RF of 0.19 for ellagic acid, 0.14 for glycyrrhizic acid and 0.58 for hesperidin. Following the International Conference of Harmonization (ICH) requirements for precision, accuracy, and reproducibility, the method was verified. The regression equation showed a linear function with...
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Posted by admin on Jun 30, 2023 in |
Understanding the preponderance of respiratory conditions with the symptoms like sore throat and cough being even more common, owing to the coronavirus outbreak. The improved resolution method was developed to quantify drugs Loratidine and Ambroxol from the most effective dosage regimen to treat sore throat and cough. An accurate, precise method was developed for concurrently estimating drugs from combined tablet dosage form by first-order derivative UV spectrophotometric method. Absorption maxima were determined as 265 nm for Ambroxol hydrochloride (ZCP for Loratadine) and 307 nm for Loratadine (ZCP for ambroxol hydrochloride), using 0.1 N HCl as a solvent for estimation. The analysis results were developed as per ICH guidelines and the drugs obeyed beer lambert’s law in a concentration range of 10 – 125 µg/mL for Ambroxol hydrochloride and 2 – 12 µg/mL for Loratadine with a regression coefficient of 0.9994 and 0.999 respectively. The %RSD values (<2) in precision studies indicate the method’s reproducibility. The LOD values were found to be 1.35µg/ml and 0.37µg/mL, and LOQ values were found...
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