Posted by admin on Sep 30, 2023 in |
This study investigates the presence of bioactive compounds present in the tubers of Curcuma zedoaria using GC-MS analysis. Different compounds, including alkaloids, tannins, flavonoids, and proteins, were identified using the preliminary phytochemical screening for aqueous, ethanol and methanol extracts. The present study reports the antimicrobial activity analysis using aqueous, ethanol and methanol extracts. The results show that the ethanol and methanol extracts showed relatively enhanced results. The extracts were subjected to GC-MS analysis, and antibacterial properties for the extracts were analyzed. Bioactive compounds such as 1,2 cyclopentanedione, 2(5H)-furanone, hexadecanoic acid, succinic acid, oleic acid, pyrrolidine etc., were identified through GC-MS. These compounds exhibited various therapeutic functions such as anticancer, anti-inflammatory, and anti-microbial activity. The antibacterial assay showed a considerable zone of inhibition for the ethanolic extracts in the case of K. pneumonia and B. subtilis. Hence, these crude extracts can be used as a better and alternative source, which can be used in herbal medicines. The study concluded that C. zedoaria tuber contains various bioactive compounds. Therefore, this tuber...
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Posted by admin on Sep 30, 2023 in |
Neurological problems should be considered a major public health issue. Around 40%–70% of people exposed to HIV suffer neurological problems such as Amyotrophic lateral sclerosis (ALS), Parkinson’s disease (PD), and other comparable conditions. Various neurological diseases including ALS, Alzheimer’s, and Parkinson’s disease are caused by amyloid-beta accumulation in extracellular regions of the brain. The Substantia nigra’s dopaminergic neurons have been damaged in a widespread and gradual manner. The life span of HIV-infected patients has risen during this period of antiretroviral medication, resulting in increased neurocognitive impairment in around 33% of HIV entities, mainly adults. The testimony of the A inscriptions in the CNS is the most popular sight among elderly HIV patients. ART is separated from harmful duplication, but the harmful neuronal protein (Tat) is still produced, following in facilitated A phases. Furthermore, Cocaine-like drug (COC) use has been linked to HIV-related neurocognitive issues and A excretion. Withaferin A is emitted by inducing the targeting Tat and COC, we suggest Withaferin A (WA), a contemporary bifunctional fragment that acts...
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Posted by admin on Sep 30, 2023 in |
Background: Hepatitis C virus (HCV) has been recognized as one of the main causes of chronic liver disease worldwide. It causes chronic hepatitis, which can progress to liver cirrhosis and hepatocellular carcinoma. HCV has different genotypes that can vary in pathogenicity and impact treatment outcomes. Identifying HCV genotypes is very important in selecting antiviral therapy, dose adjustment of antiviral drugs, determination of duration of treatment, and follow-up of the treatment response. Objectives: To determine the genotype of HCV in HCV-positive patients. Materials and Methods: We included 100 anti-HCV-positive patients. HCV RNA (Ribo Nucleic Acid) identification and HCV genotyping assays of the positive specimens were performed by Real-Time Polymerase Chain Reaction (PCR). Results: Of the 52 HCV RNA-positive cases, Males were more preponderant than females, and the were years. Genotype 3 (n = 40; 76.9%) accounted for the highest number of cases, was only present one case (n = 1; 1.9%), while genotype 4 could not be detected at all was found to be genotypes in the Western part of...
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Posted by admin on Sep 30, 2023 in |
Ophthalmic delivery for eye drops which currently cover to 90% of available ocular dosage forms are ideal for the treatment of eye diseases but having limitations of poor therapeutic response and low bioavailability. Objectives: The objectives of present research was to develop of formulation and characterize sustained release in-situ ocular gels containing ciprofloxacin hydrochloride using pH induced gelling polymers for increase drug retention time on eye surface which improved therapeutic response and patient compliance. Methods: In-situ gel formulations prepared by dispersion method using Carbopol-940 alone or in combination with hydroxypropyl methylcellulose (HPMC K4M). Formulations were evaluated for appearance, pH, viscosity, gelling capacity, and drug content and in vitro drug release. The optimized formulation was assessed for sterility and antimicrobial efficacy using disk diffusion technique. Results: The appearance of in situ gels were clear and free flowing in nature however, a viscous clear solution with flow was normal as solution state after gel conversion flow behavior was change. All formulations consisting 0.01%-0.09 %w/v of Carbopol-940 and 0.05% w/v HPMC K4M....
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Posted by admin on Sep 30, 2023 in |
Objective: This study aimed to identify the drug utilization pattern in poisoning patients admitted to tertiary care hospitals and study poisoning patients to determine type of poison cases, demographic character, psychiatric illness, and treatment pattern among poisoning patients. After taking approval from the ethics committee, the study was conducted at Adesh Hospital (AIMSR), Bathinda. Method: This study was conducted for 6 months and data were obtained from 65 patients admitted in the hospital with poisoning. In-patient and emergency department drug utilization studies of poisoning patients were studied, and data were recorded in the patient profile form. The recorded data were analyzed as per the objective of the study. Result: Poisoning episodes were the majority for suicide in 20-29 years (30.8%). Most of the poisoning cases were due to organophosphorus compound consumption of 28 cases, (43.1%). Antidotes like atropine with pralidoxime (24.6%), Glycopyrrolate (36.9%), and other drugs like antibiotics, steroids, analgesics, antiemetics, proton pump inhibitors, antiepileptic agents, and intravenous fluids were utilized for the management of poisoning cases under...
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