Posted by admin on May 1, 2013 in |
Natural products have been closely linked through the use of traditional medicines and natural poisons. Mushrooms have an established history of use in traditional oriental medicine, where most medicinal mushroom preparations are regarded as a tonic, that is, they have beneficial health effects without known negative side-effects and can be moderately used on a regular basis without harm. Mushrooms comprise a vast and yet largely untapped source of powerful new pharmaceutical products. In particular, and most importantly for modern medicine, they represent an unlimited source of compounds which are modulators of tumour cell growth. Furthermore, they may have potential as functional foods and sources of novel molecules. In the present study, we have reviewed the compounds with anti-tumor potential in some of the new wild varieties of mushroom of Rajouri Dist. of Jammu and Kashmir region. The main anti-tumor compounds prominent in such species comprises low-molecular-weight compounds viz. quinones, cerebrosides, isoflavones, catechols, amines, triacylglycerols, sesquiterpenes, steroids, organic germanium and selenium) and high-molecular-weight compounds viz. homo and heteroglucans, glycans, glycoproteins,...
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Posted by admin on Apr 1, 2013 in |
Camellia sinensis and Citrus sinensis are treasuries of medicinal properties. The compounds present in these plants can deliver potential therapeutic drug. Most of the drugs in clinical development fail to commercialize because of poor ADME and toxicity properties. The main aim of the study is pharmacokinetic investigation and toxicity property, the most causes of high attrition rates in drug development and it should be considered as early as possible in the drug discovery...
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Posted by admin on Apr 1, 2013 in |
Plants rich in antioxidants and phytochemicals especially phenolic groups play a protective role in health and disease conditions, like cancer, diabetes, heart disease hypertension etc. by counteracting reactive oxygen species and inhibiting the lipid oxidation. Morus indica is non-toxic natural therapeutic plant used as herbal medicine as hypoglycemic, hypotensive, and diuretic properties. In the present study proximate, phytochemical and antioxidant profile in dehydrated leaves powder of Morus indica varieties, M5, V1 and S36 were estimated. The 100% methanol, 80% methanol (methanol & water, 8: 2), dechlorophyllised, aqueous cold and hot extracts were prepared and their polyphenol content, antioxidant activity of inhibiting oxidation in oil emulsion and liver microsomes was evaluated at 300 to 500µg. There was no significant (P<0.05) difference in the moisture, fat and ash content. All the three samples were found to be good sources of major minerals viz. Iron, Calcium phosphorus and also of trace elements like manganese, zinc, copper, potassium.S36 found to be rich in phytochemicals and antioxidants. The polyphenol content was in the order...
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Posted by admin on Apr 1, 2013 in |
The aim of the present investigation is to formulate and evaluate Tizanidine hydrochloride sustained release pellets. Tizanidine hydrochloride is an immadazole α2-adrenergic agonist used in the management of increase in muscle tone associated with spasticity. It has short biological half-life of 2- 2.5 hrs and is rapidly eliminated from the body. Sustained release dosage form of Tizanidine hydrochloride was developed for reduction in total amount of dose administration, to improve patient compliance, and increase efficiency in the treatment. The pellets were prepared by pan coating and fluidized bed coating technique (Wurster type) using hydroxy propyl methyl cellulose E5 (HPMC E5), Ethyl cellulose N-50, Eudragit L-100 as polymers and Isopropyl alcohol, Methylene dichloride as solvents. The pellets are filled in capsules and evaluated for weight variation, content uniformity, moisture content, lock length, disintegration and in-vitro dissolution tests and the results were found to be within the limits. A comparative study of dissolution profile of different batches with marketed product was performed. The optimized batch showed good similarity with the marketed...
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Posted by admin on Apr 1, 2013 in |
A simple and sensitive spectrophotometric method has been developed for the determination of Clomipramine in bulk and tablet dosage forms. The method was based on the charge transfer reactions of Clomipramine with 2, 3-dichloro-5, 6-dicyano-1, 4-benzquinone. The absorbance of the highly intensive coloured solution was measured at 470 nm against reagent blank treated similarly. Beer’s law is obeyed in the concentration range of 50-250 μg/ml. Statistical analysis proves that the proposed method is reproducible and selective for the routine analysis of pharmaceutical formulations of...
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