Posted by admin on Jun 1, 2013 in |
Solid lipid nanoparticle proved appropriate as prolonged release formulation for lipophilic drugs. The present work dealt with the preparation of the antifungal lipophilic drug nystatin into solid lipid nanoparticles ((Nyst-SLNs).) formulation for topical delivery with the aim to prolong its release and effectiveness. Hot homogenization and ultrasonication were applied in the production of (Nyst-SLNs). Different matrix material and stabilizers were tested. All the formulations were subjected to particle size analysis, zeta potential, drug entrapment efficiency and in-vitro release studies. Transmission electron microscopy was conducted to investigate the morphology of nystatin loaded nanoparticles. The differential scanning calorimetry visualized the dispersed amorphous state of nystatin in the SLN. In addition, the present study addresses the compositions of different formulation on the physicochemical properties and drug release profile of...
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Posted by admin on Jun 1, 2013 in |
In the present study, analgesic and anti-inflammatory activities of the synthesized agents derived from Ugi four component reactions (Ugi-4CR) has been described. The synthesized novel Ugi derivatives 7 (a-h) were characterized on the basis of I.R, 1H NMR and mass spectral analysis. Healthy Wistar Albino rats were used to carry out these activities. Analgesic activity was evaluated by Eddy hot plate method using Morphine Sulfate as a standard reference drug. Anti-inflammatory activity was evaluated by mercury displacement method using Diclofenac as standard reference drug. The results were expressed as mean ± S.E.M. The data were statistically analyzed by Student’s t test and P<0.05 were considered as significant. The screening data shows that synthesized compounds possess potential analgesic and anti-inflammatory...
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Posted by admin on Jun 1, 2013 in |
The purpose of this research was to develop and evaluate naturally obtained polysaccharides (Tamarind seed polysaccharide and Pectin) as a carrier in colon targeted drug delivery systems a colon targeted drug delivery. The newer developments in this context aim for an increased selectivity of drug delivery by targeting mechanisms which have a closer relation to pathophysiological particularities of the disease. The polysaccharides were characterized of its physical properties. The interaction between the excipcents and prednisolone was also studied through FTIR spectroscopy. Tablets were then prepared by wet granulation method with different ratio of polysaccharides and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. In vitro drug release studies were performed in conditions simulating stomach to colon transit. No significant release was observed at acidic pH, however, when it reached the colonic pH where, drug release was observed. Also, release of drug was found to be higher in presence of rat caecal content. Data were fitted to various kinetic models. The mechanism of drug release...
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Posted by admin on May 1, 2013 in |
Nystatin is bacterial originated polyene antifungal agent. The aim of the study is to develop the niosomal nystatin gel for transdermal administration. Formulations were developed using thin film hydration technique. Developed formulations were characterized for particle size, shape, % entrapment efficiency, in vitro drug release, etc. After analyzing the results, best formulation is optimized and its zeta potential, stability was determined. Niosomal gel was prepared with optimized formulation using carbopol as gelling agent. In vitro drug release from formulated niosomal gel and marketed preparation was carried out. The niosomes appeared spherical in shape and the size range of niosomes in all formulations was found to be 278±1.4 to 431±1.2nm. Highest and least % entrapment was shown by FN3 (72.5±1.9) and FN5 (51.2±2.2) respectively. In vitro drug release of all formulations was carried out using exhaustive dialysis method. FN3 formulation was selected as an optimized formulation because of its good entrapment efficiency and drug release pattern. In vitro & Ex vivo drug release studies of niosomal gel and marketed formulation...
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Posted by admin on May 1, 2013 in |
Effervescent tablets or granules are uncoated and generally contain acidic substances and carbonate or bicarbonate which reacts rapidly to release carbon dioxide when dissolved in water. There are various advantages of effervescent formulations such as fast onset of action, good stomach tolerance, improves palatability, enhanced permeability, but a major problem which is associated with these formulations is their sodium content which is present in the form of sodium bicarbonate. According to various guidelines the per day sodium intake is advised to be limited by 2400 mg. This excess sodium would produce health complications particularly to cardiac and renal patients. The main objective of present work was to use a non-alkali carbonate to avoid the problems which may occur due to presence of alkali carbonates in effervescent preparations. Arginine carbonate was found to be a suitable carbonate source as it has an additional advantage of being an amino acid source. Arginine carbonate was produced in the laboratory by saturating the solution of arginine in DM water with carbon dioxide and...
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