Posted by admin on Apr 1, 2013 in |
The goal of the present study was to investigate the feasibility of using non-ionic surfactant vesicles as carriers for the sustained delivery of water soluble anti-cancer drug Capecitabine, used in the treatment of colorectal cancer. The niosomal formulations were prepared using various non-ionic surfactants (span 40, span 60, tween 40 and tween 60) in the presence of cholesterol, by thin film hydration technique. The effect of process related variables like hydration time, sonication time, rotation speed of evaporation flask on the entrapment efficiency and in vitro drug release were evaluated. Formulation of Capecitabine niosomes was optimized by altering the proportions of Tween, Span and cholesterol. The formation, morphology and size of the drug loaded niosomes were determined by optical microscopy, transmission electron microscopy and particle size analyzer respectively. Results showed a substantial change in the release rate and in the % Entrapment of Capecitabine from niosomal formulations upon varying the type of surfactant and cholesterol content. In-vitro drug release results confirmed that the niosomal formulations have exhibited a higher...
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Posted by admin on Apr 1, 2013 in |
Background: In India because of growing pressure on the healthcare budget, appropriate justification of current expenditures and future investments in public healthcare are becoming a priority. COPD is a major cause of healthcare burden worldwide and it is the one of leading cause of death with increasing the prevalence. Objective: To evaluate the pharmacoeconomic impact of acute COPD exacerbations in a rural tertiary care hospital. Methodology: It is a prospective, observational study conducted in COPD in patients over a period of 9 months. The patients who satisfied the study criteria were enrolled. Results: Over all 50 were enrolled including 42 male and 8 female COPD patients. 60%of patients stayed over a period of 6-10 days in hospital. 4% of patients had a history of duration of illness >10 years. 64% of patients were farmers and only 4% had a monthly income Rs. >10000. 44% had a history of past smoking and 6% were smokers. 34% of patients had co-morbidities with COPD. Minimum total direct medical cost was Rs. 188.79...
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Posted by admin on Apr 1, 2013 in |
Obstructive sleep apnea (OSA) has been increasingly linked with cardiovascular risk factors. Mechanisms such as increased sympathetic activity and endothelial dysfunction have been implicated. There are many factors which are responsible for the cardiovascular morbidity in OSA patients they are Obesity, C-reactive protein (CRP) and lipid profile. To study the impact of nasal continuous positive airway pressure (nCPAP) treatment on CRP levels in OSA patients. Average AHI of each subjects was; Mild OSA 11.02±2.62 Events / hour, Moderate OSA 22.48±3.90 Events / hour and Severe OSA 55.12±21.04 Events / hour. Out of 141 patients 110 were male (78.09%) and 31 were female (21.98%). The mean age of male and female in the study population was 52.22±5.12 and 49.11±4.12 years respectively. The average BMI for OSA patients was 31.48±6.8 kg / m2. A significant association was found between AHI and BMI (r=0.195 and p<0.02). Serum levels of CRP during baseline and after 6 months of nCPAP treatment were compared. The mean values of CRP of the study population were 8.45±4.30.32...
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Posted by admin on Apr 1, 2013 in |
1, 5-Benzothazepinyl chromones were synthesized starting from 2, 4-diacyl phenol. The 2, 4-diacyl phenol was condensed with aryl aldehydes to obtain bis-chalcones1a-d. The bis-chalcones on cyclocondensation with equimolar amount of 2-aminothiophenol gave 1, 5-benzothiazepinyl chalcones2a-d. The chalcones on oxidative cyclisation in DMSO – I2 yielded the titled compounds3a-d. The microbial evaluation of the representative 1, 5-benzothiazepinyl chromones has also been...
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Posted by admin on Apr 1, 2013 in |
Background: For many years, creatinine clearance has become increasingly popular because of several advantages. The major error arises in clearance test when the timing of urine collection is inaccurate and the bladder is incompletely empty. Aim: In view of the aforementioned controversial literature, it was decided to evaluate the relation-ship between the renal changes (creatinine clearance) in pre-eclamptic, eclamptic, preeclamptic toxeaemic, non-pregnant and normal pregnant women. Setting and Design: The present investigations were undertaken to study creatinine clearance in normal non-pregnant women, pregnant women in different trimesters, Preeclamptic toxaemic patients and eclamptic patients, between the age group 25-32 years admitted in Rajendra Institute of Medical Sciences, Ranchi during the period from June 2008 to September 2009. Methods and Material: Control group consisted of 15 normal non-pregnant women, 10 cases in first trimester, 30 cases in 2nd trimester, 20 cases in 3rd trimester, 60 cases of Preeclamptic toxaemia and 20 cases of eclampsia. Creatinine clearance measurements were done by enzymatic method and modified Jaffe’s kinetic method. Statical Analysis: Statistical analysis...
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