Posted by admin on Mar 1, 2013 in |
Solanum sisymbriifolium (Solanaceae) and Jatropha gossypifolia (Euphorbiaceae) have long been used in folkloric medicine for the treatment of various ailments. The purpose of the present study was to evaluate the cytotoxic activity of the plants and to make available the process of data analysis of cytotoxic studies to the researchers. A general toxicity of the extracts was assessed by a simple and low cost assay using brine shrimp lethality as an indicator of toxicity. Ethanol crude extract and fractions of the extract of leaves of Solanum sisymbriifolium exhibited relatively mild cytotoxic activity compared to that of flowers and fruits against brine shrimp larvae with median lethal concentration, LC50 values ranging from 10.10 – 321.35 and 13.19 – 80.16 μg/ml, respectively. Methanol crude extract and fractions of the extract of leaves of Jatropha gossypifolia exhibited significant toxicity against the shrimps (LC50 values 17.19 – 98.19 μg/ml), while that of potassium permanganate, a positive control, was 11.27 μg/ml. Among the fractions of the crude extracts of both plants, non-polar fractions such...
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Posted by admin on Mar 1, 2013 in |
Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective model. Animals pretreated with ethanolic extract of Ficus religiosa L at the dose 200 mg/kg and 400 mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggested that the extract at 200 mg/kg and 400 mg/kg showed significant protection (P<0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that Ficus religiosa L. bark and rootextract shows significant antiulcer...
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Posted by admin on Mar 1, 2013 in |
A simple and sensitive visible spectrophotometric method is described for the assay of risperidone (RSP) in pure and solid dosage forms. The method involves oxidative coupling of risperidone with MBTH in presence of ferric chloride dissolved in HCl and apple green chromogen is formed and exhibits absorption maxima at 595.8nm. Regression analysis of Beer-Lambert plots showed good correlation in the concentration ranges (10-80) μg/mL. Regression coefficient was found to be 0.992. The proposed method is applied to commercial available tablets and the results are statistically evaluated and validated by recovery studies. The proposed methods have been successfully applied to the analysis of the bulk drug and its tablet dosage form. The methods have been statistically evaluated and were found to be precise and...
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Posted by admin on Mar 1, 2013 in |
With respect to Chhattisgarh, rice is the principal crop of the state. India Covers 66% of cultivable land and mostly grown under kharif cropping season. To increase sustained productivity without decreasing soil quality, algal bio fertilizers are used widely now days in the state. Use of local isolates as algal inoculants is being stressed due to their competitiveness in the field for establishment of better ecological adaptability for developing composite starter. Culture of algal bio fertilizer programme on a regional basis, survey, isolation and screening of stress-tolerant cyanobacteria have been started at various parts of India. The soils of Chhattisgarh state comprise mostly of iron- rich red soil, laterite soil, and red and yellow soil and brown forest soil. So the above study comprises the characterization of physical and chemical properties collected from 4 districts of Chhattisgarh...
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Posted by admin on Mar 1, 2013 in |
Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, reasoning, planning, language, and perception, and eventually even the ability to carry out the simplest tasks. Many scientists believe that Alzheimer’s disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain that leads to nerve cell death.The brains of people with AD have an abundance of two abnormal structures amyloid plaques and neurofibrillary tangles that are made of misfolded proteins. This is especially true in certain regions of the brain that are important in memory. In people with Alzheimer’s disease, deposits called amyloid plaques build up in the brain. These are composed, in part, of a protein called beta-amyloid, which is a fragment of the amyloid precursor protein (APP).A mutation in the gene that makes APP is believed to be responsible for 5 to 20 percent of all early onset familial Alzheimer’s disease. People with a mutation in the APP gene tend to develop...
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