Posted by admin on Jun 1, 2013 in |
The purpose of this research was to develop and evaluate naturally obtained polysaccharides (Tamarind seed polysaccharide and Pectin) as a carrier in colon targeted drug delivery systems a colon targeted drug delivery. The newer developments in this context aim for an increased selectivity of drug delivery by targeting mechanisms which have a closer relation to pathophysiological particularities of the disease. The polysaccharides were characterized of its physical properties. The interaction between the excipcents and prednisolone was also studied through FTIR spectroscopy. Tablets were then prepared by wet granulation method with different ratio of polysaccharides and evaluated for their physical properties like weight variation, hardness, friability and content uniformity. In vitro drug release studies were performed in conditions simulating stomach to colon transit. No significant release was observed at acidic pH, however, when it reached the colonic pH where, drug release was observed. Also, release of drug was found to be higher in presence of rat caecal content. Data were fitted to various kinetic models. The mechanism of drug release...
Read More
Posted by admin on May 1, 2013 in |
Nystatin is bacterial originated polyene antifungal agent. The aim of the study is to develop the niosomal nystatin gel for transdermal administration. Formulations were developed using thin film hydration technique. Developed formulations were characterized for particle size, shape, % entrapment efficiency, in vitro drug release, etc. After analyzing the results, best formulation is optimized and its zeta potential, stability was determined. Niosomal gel was prepared with optimized formulation using carbopol as gelling agent. In vitro drug release from formulated niosomal gel and marketed preparation was carried out. The niosomes appeared spherical in shape and the size range of niosomes in all formulations was found to be 278±1.4 to 431±1.2nm. Highest and least % entrapment was shown by FN3 (72.5±1.9) and FN5 (51.2±2.2) respectively. In vitro drug release of all formulations was carried out using exhaustive dialysis method. FN3 formulation was selected as an optimized formulation because of its good entrapment efficiency and drug release pattern. In vitro & Ex vivo drug release studies of niosomal gel and marketed formulation...
Read More
Posted by admin on May 1, 2013 in |
Effervescent tablets or granules are uncoated and generally contain acidic substances and carbonate or bicarbonate which reacts rapidly to release carbon dioxide when dissolved in water. There are various advantages of effervescent formulations such as fast onset of action, good stomach tolerance, improves palatability, enhanced permeability, but a major problem which is associated with these formulations is their sodium content which is present in the form of sodium bicarbonate. According to various guidelines the per day sodium intake is advised to be limited by 2400 mg. This excess sodium would produce health complications particularly to cardiac and renal patients. The main objective of present work was to use a non-alkali carbonate to avoid the problems which may occur due to presence of alkali carbonates in effervescent preparations. Arginine carbonate was found to be a suitable carbonate source as it has an additional advantage of being an amino acid source. Arginine carbonate was produced in the laboratory by saturating the solution of arginine in DM water with carbon dioxide and...
Read More
Posted by admin on May 1, 2013 in |
Aim: To evaluate anti-inflammatory effects of losartan in experimentally induced rheumatoid arthritis (RA). Materials and Methods: Adjuvant induced arthritis model is used in this study. Albino-Wistar rats of either sex were used. Arthritis was induced by single intra-plantar injection of Freund’s complete adjuvant (FCA) suspended in oil in right hind paw. Rats were divided in to three groups (n=8) namely disease control, standard and test group. Drug treatment was carried out for 21 days. Effect of test drug on acute inflammatory phase was evaluated on day 5 by assessing right hind paw edema. After 21 days animals were sacrificed and evaluated for left hind paw edema, weight changes, histo-pathological synovitis grading in left hind limbs and secondary lesion score. Results: Results showed that losartan significantly reduced right hind paw edema on day 5 (p<0.05) and showed significant weight gain (p<0.05). Losartan though reduced the histo-pathological synovitis grade and secondary lesion score was not statistically significant (p>0.05). Conclusion: Our study suggests that losartan could be a potential candidate for treatment...
Read More
Posted by admin on May 1, 2013 in |
Oral controlled release pellet formulations of glipizide were prepared using extrusion spheronization technique. Pellets provide specific advantages in controlling the drug release and increasing the absorption of the active ingredient. The major drawback for these systems is dose dumping which is very prominent in presence of alcohol. In the present study, attempt was made to prepare alcohol resistant pellet formulations of glipizide. Glipizide is an oral anti-diabeticdrug belonging to the sulfonylurea group, used for the treatment of non-insulin dependent diabetes mellitus (NIDDM). Various polymers like Eudragit RSPO, RLPO and cellulose acetate butyrate were used for preparing the pellets. The prepared pellets were studied for different flow properties and drug release studies. The in vitro drug release studies were carried out in phosphate buffer as well as in phosphate buffer containing 5% alcohol. Drug release from the pellets was by non fickian diffusion mechanism and was comparable with that of marketed preparations. The pellets also had shown resistance to alcohol dose...
Read More
