Posted by admin on Mar 1, 2013 in |
Turmeric (Curcuma longa) is a rhizomatous herbaceous perennial plantused as a food additive. It has been reported that rhizome of this plant have antibacterial, antifungal, anti-inflammatory, antioxidant and antitumor property. Methanol extract of Rhizome of Curcuma longa was investigated here to see the antimicrobial actions and anti-inflammatory effect. During the extraction process a purified single compound (D1) was isolated and investigated for its antimicrobial activity. Significant antimicrobial activity than penicillin were found for 500µg C. longa extract. Anti-inflammatory action of C. longa was also assessed using mice models. The purified compound D1 fraction showed antimicrobial action in 50µg concentration. Our study reveal that C. longa has antimicrobial activity against various gram positive and gram negative bacteria where curcumin may not be the only compound that is responsible for the antimicrobial activity. On the other hand, C. longa extract had shown significant anti-inflammatory...
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Posted by admin on Mar 1, 2013 in |
Alzheimer’s disease (AD) is an irreversible, progressive brain disease that slowly destroys memory and thinking skills, reasoning, planning, language, and perception, and eventually even the ability to carry out the simplest tasks. Many scientists believe that Alzheimer’s disease results from an increase in the production or accumulation of a specific protein (beta-amyloid protein) in the brain that leads to nerve cell death.The brains of people with AD have an abundance of two abnormal structures amyloid plaques and neurofibrillary tangles that are made of misfolded proteins. This is especially true in certain regions of the brain that are important in memory. In people with Alzheimer’s disease, deposits called amyloid plaques build up in the brain. These are composed, in part, of a protein called beta-amyloid, which is a fragment of the amyloid precursor protein (APP).A mutation in the gene that makes APP is believed to be responsible for 5 to 20 percent of all early onset familial Alzheimer’s disease. People with a mutation in the APP gene tend to develop...
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Posted by admin on Mar 1, 2013 in |
The reagent was synthesized and characterization was carried out by FTIR, NMR, elemental analysis as well as Mass spectrometry. This reagent was then applied for the development of the analytical method for the extractive spectrophotometric determination of Cobalt (II). Cobalt metal forms yellow coloured complex, which can be extracted in chloroform at pH 9.0 having absorption maxima at 430 nm. Beer’s law is obeyed in the concentration range 1-10 μg. The molar absorptivity and Sandell’s Sensitivity of the extracted species are found to be 5.8470 X 103 Lit mol-1 cm-1 and 10.088 X 10-3 µg / cm2 respectively. The developed method is highly sensitive, selective, simple, rapid, accurate, and has been satisfactorily applied for the determination of cobalt in the synthetic mixtures, pharmaceutical samples, and...
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Posted by admin on Mar 1, 2013 in |
Background: In Ethiopia 10.6% and Addis Ababa, 30% of the population has been estimated to have hypertension. Adherence to medication therapy and lifestyle change is an aspect of patients’ care that is often overlooked and should be evaluated as a crucial part of cardiovascular management. Objective: The aim is to assess adherence and influencing factors of adherence to hypertensive management among hypertensive patients in Black Lion Hospital chronic follow up unit, Ethiopia. Methods: A cross-sectional study was conducted. Systematic sampling technique was used to select 286 study subjects. A structured standard interviewer administered questionnaire was used after some modifications. Analysis was done using SPSS 16. P-value <0.05 was considered significant association. Scoring method was used to classify patients’ level of adherence. Results: Of 286 subjects included in the study 165(57.7%) were female and mean age was 52±13 year. The adherence level of respondents to medication, diet and exercise were 69.2%, 64.7%, and 43.7% respectively. The medication and diet related adherence were found to be better in patients who had...
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Posted by admin on Mar 1, 2013 in |
Candesartan was degraded together under different stress test conditions prescribed by International Conference on Harmonization. The samples so generated were used to develop a stability-indicating high performance liquid chromatographic (HPLC) method for the candesartan. The drug was well separated from degradation products using a reversed-phase (C-18) column and a mobile phase comprising of Acetonitrile: Buffer (80:20 v/v) at pH- 3. Other HPLC parameters were: flow rate, 1 mL/min; detection wavelength, 225 nm; and injection volume 20 µl. The method was validated for linearity, precision, accuracy etc. Results obtained after validation study, indicating that the proposed single method allowed analysis of Candesartan, in the presence of their degradation products formed under a variety of stress conditions. The developed procedure was also applicable to the determination of stability of the drug in commercial pharmaceutical dosage...
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