Posted by admin on Jul 31, 2023 in |
Introduction: Due to the appropriate use of antibacterials, management of infectious diseases has undergone a revolutionary change. However, inappropriate use leads to several problems, including increased antibacterial resistance, adverse drug reactions, infection severity, increased treatment cost, and health care burden. Antibacterials drug utilization studies are valuable in overcoming the inappropriate and promoting the appropriate use of antibacterials. Therefore, the current study aims to estimate the pattern of antibacterial drug utilization by using WHO prescribing indicators. Material & Methods: A Non-interventional, Cross-sectional study was conducted among 800 OPD patients of SHKM, GMC, Nuh, and Haryana over a period of 12 months. A simple random sampling technique was employed to select prescriptions during data collection. Data processing and analysis were done using SPSS version 20. Results: 2105 patients were screened, and 800 patients were included in the study based on inclusion criteria. It was found that the maximum number of patients were in the adult age group (43%), followed by 29.8% in the paediatric age group. There were 4.56 drugs prescribed...
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Posted by admin on Jul 31, 2023 in |
The clinical features, disease progression, and outcome of Covid-19 in pregnant patients are not entirely understood. Many research studies came with different findings about Covid-19 infection in pregnancy. The present study demonstrates the clinical profile and neonatal outcomes of pregnant women affected by Covid-19. An observational study was conducted in a secondary and tertiary care private hospital, Rising Medicare Hospital in Pune city, Maharashtra. Pregnant women with Covid-19 infection admitted from1st March 2021 to 31st Aug 2021 were followed until they were discharged. After the consent, essential data was collected with the help of installed software. The maternal and feta outcomes and vertical transmission were accessed. A total of twenty-one cases participated in this study. Ten patients (47.62%) had a history of contact with Covid-19 infected patients and 19 (90.48% patients) were discharged with the continuation of pregnancy without any complication. One maternal death occurred due to Covid related complications. Out of five live births, one baby showed vertical transmission. The present study determined the incidence of vertical transmission,...
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Posted by admin on Jul 31, 2023 in |
Rheumatoid arthritis (RA) causes joint disability due to pannus formation, synovitis, joint erosion, joint destruction and cartilage damage. Disease-modifying antirheumatic drugs (DMARDs) and nonsteroidal anti-inflammatory drugs (NSAIDs) prevent the disease progression but suffer the disadvantage of severe adverse drug reactions. An extensive literature search revealed reports of 176 phytoconstituents having anti-inflammatory and/or anti-arthritic activity. Their binding affinities to TLR-4 and NLRP3 receptors were predicted by molecular docking using target proteins of TLR4-MD2 (PDB ID: 3FXI) and chain A and chain B of NLRP3 (PDB ID: 6NPY). Docking score results revealed that 11 phytoconstituents with promising inhibition of TLR4-MD2 along with 27 phytoconstituents inhibiting binding to Chain A of NLRP3 and 65 phytoconstituents binding to Chain B of NLRP3 proteins were identified through an extra precision (XP) docking study by comparing standard antagonists of TLR4 such as Resatorvid and standard antagonists of NLRP3, i.e., MCC950 and Anakinra. Further, we analyzed the pharmacokinetic properties (absorption, distribution, metabolism, excretion, and toxicity) of selected phytoconstituents using pKCSM. Thus, this study reveals that the...
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Posted by admin on Jul 31, 2023 in |
It is an ornamental shrub native to Madagascar and the Philippines, widely distributed in India. Euphorbia milii Des Moul is widely used in folk medicine to treat warts (South Brazil), cancer and hepatitis in (China). The present study seeks to evaluate the methanolic aerial extract of Euphorbia milii Des Moul (MAEEM) for its anti-diabetic effect against streptozotocin–nicotinamide induced type 2 diabetic model in Albino Wistar rats. Oral glucose tolerance test, Phytochemical screening and Acute toxicity study were carried out. Graded doses of MAEEM (100mg/kg, 200mg/kg and 400mg/kg) were administered to diabetic rats for 21 days. The activity was evaluated by using some biochemical parameters such as blood glucose levels, serum lipid profiles, liver profile markers (AST, ALP, ALT), and renal profile markers (serum creatinine, blood urea). Type-2 diabetes significantly altered these parameters, while oral administration of the MAEEM significantly ameliorated...
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Posted by admin on Jul 31, 2023 in |
Eslicarbazepine acetate is a chemical compound that has found medical use as a partial seizure drug. Monitoring of heavy metals (As, Mn, Cd, Cr, V, Mo, Cu, and Sb) in-process, intermediates, and final drug substances is an important activity in the pharmaceutical industry because of the potential for toxicity and the risk of serious health hazards even at very low doses. This research article established and validated an easy and rapid analytical method for determining eight heavy metals in Eslicarbazepine acetate. Drugs must first be processed through acid digestion using microwave radiation before being analyzed for these elemental impurities. The % RSD of the LOQ solution was found to be < 20.0 for all the elements. The analytical method seems linear, with a correlation coefficient > 0.99. Eslicarbazepine acetate sample amounts spiked at three different concentrations, resulting in acceptable percentage recoveries of heavy metal ions ranging from 70% to 150%. Individually, precision and robustness for all conditions met the acceptable limits. Heavy metal analysis by ICP-MS is a powerful...
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