Posted by admin on Jan 1, 2013 in |
Felodipine is a long-acting 1, 4-dihydropyridine calcium channel blocker, used to control hypertension by selective action on peripheral resistance. The conventional felodipine tablet gives a rather high peak and comparatively low trough levels, due to rapid absorption and distribution. More sustained plasma concentrations might thus produce a more even effect on blood pressure. The main aim of the study was to improve dissolution rate of the dosage form in a controlled manner over extended period of 24 hrs. Matrix tablets were prepared by direct compression method,using hydrophobic polymers like Glyceryl monostearate and Carnauba wax. The prepared formulations were evaluated for hardness, thickness, weight variation, friability and in-vitro dissolution studies. Among all the formulations F8 was selected as optimized formulation based on the evaluation parameters and in-vitro release profile of 100% drug release for 24 hrs. The FTIR and DSC results of optimized formulation showed no drug-excipient interaction. For optimized formulation(F8), the drug release mechanism was explored and explained by zero-order (r2=0.984), first-order (r2=0.947), Higuchi (r2=0.967) and Korsmayer-peppas (r2=0.982 &...
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Posted by admin on Jan 1, 2013 in |
The present time is an era of revolution as rapid changes and developments have been noticed in almost all spheres around the globe. In most of the countries the private sector has played a pioneer role to introduce several changes. The pharmaceutical industry through research and development has brought out a variety of products. There is much of experimentation, researches and trials. The improved technology in pharmaceutical industry requires a wide variety of essential manufacturing equipments and material. In the process of manufacturing, since a wide range of activities are involved this has an adverse impact on the environment. Thus it brings along matters of concern. With the changing time, the era of modernization is coming up with many more problems. To cope with such problems, the production of drugs is also being carried out on a massive scale. The procedures involved in these activities and manufacturing of drugs causes several, perhaps unnoticeable, environmental tribulations. So, the pharmaceutical companies should take it as a social and moral responsibility to...
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Posted by admin on Jan 1, 2013 in |
The main objective of this study was to prepare controlled release matrix type ocular inserts of mizolastine for the treatment of seasonal allergic conjunctivitis.The films were prepared by solvent casting technique using Eudragit RL100 and RS100 in different ratios with dibutylphthalate as the plasticizer. The films were evaluated for the physicochemical parameters. In-vitro studies were carried out using Franz-diffusion cell (bi-chamber compartment model)and ex-vivo studies of the optimized formulation were carried out using goat’s cornea. In vivo studies were performed using rabbit as the animal model. Formulations F4andF6, which showed controlled and prolonged in vitro drug release, were subjected to in vivo study. In vitro and in vivo correlation was found to be good, revealing the efficacy of the formulations.Formulation F6 was found to be promising, as it achieved the objective of the present...
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Posted by admin on Jan 1, 2013 in |
The present study was aimed at developing an oral floating system for Enalapril maleate with the objective to enhance the oral bioavailability of the drug. As it is a prodrug, oxidizing agent KMnO4 was used with distilled water and observed at 340 nm against a reagent blank, using PC Shimazdu UV Spectrophotometer. The obtained standard graph of drug was a straight line with coefficient correlation (R 2) = 9.9984. 12 formulations were prepared in 2 batches using varying concentration of hydrophilic swelling polymer HPMC K15 M and effervescent agent i.e. NaHCO3. Having a light sensitive drug all the experimental work had been done in the dark light room. Among the different formulation B1F6was considered as optimized formulation with a floating lag time of only 20 sec and floating time of more than 10 hour showed better floating behavior. It showed the release up to 60% of drug in 8 hr .The release of Enalapril maleate from all the formulations fitted to different release kinetic models, indicated that formulation B1F1...
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Posted by admin on Jan 1, 2013 in |
Staphylococcus aureus ATCC 6538 is an important strain of pharmaceutical and biotechnological industries. We studied the viability of culture suspension of Staphylococcus aureus strain ATCC 6538 at 2 to 8°C up to 360 days in 0.9% w/v NaCl. The culture suspension containing 10000 cfu/ml used in the study was stored at 2 to 8°C for 360 days in 0.9% w/v NaCl. Using 10 µl of above culture suspension, the viable count was made by the pour plate technique using Soyabean Casein Digest Agar medium in fixed interval of time during the 360 days storage period. During the storage period, population of Staphylococcus aureus ATCC 6538 strain decreased from 10000 cfu/ml to 9900 cfu/ml during the first 30 days, whereas the population decreased to 0 cfu/ml in 360 days. Findings emanate from the study indicates that 30 days storage period of Staphylococcus aureus strain ATCC 6538 at 2 to 8°C in 0.9% w/v NaCl is suitable for laboratories testing purposes on account of fact that in 30 days storage period,...
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