Posted by admin on Sep 30, 2023 in |
Phyllanthus reticulatus Poir., of family Euphorbiaceae was an important therapeutic plant in the traditional medicine, and gaining favour in modern medicine as a plant with varied pharmacological properties. This sericeous shrub is also known as Kirganelia reticulata is widely distributed in India, Thailand, China, Africa and Malaysia. Mouthwash, gargles, mouth spray were formulations were modified using leaves, fruit and stem extract of the plant. The extract of Phyllanthus reticulatus Poir., were studied to have antibacterial, antimicrobial as well as anti-inflammatory activity. Various qualitative tests were performed to authenticate the plant and its property. Presences of alkaloids, phenolic compounds, tannins, coumarins in extract were indicated by the phytoconstituents and UV spectral tests. The extract was found to be stable at acidic state. Fruit extract of Phyllanthus reticulates contain anthocyanin (Delphinidin) which ere detected by TLC and HPTLC. The modified formulations showed good sensitivity towards strains of S. mutans in comparision with marketed product containing Chlorhexidine. The accelerated study proves that the modified products are stable at room temperature. Hence a...
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Posted by admin on Sep 30, 2023 in |
Background: Gastroesophageal reflux disease (GERD) is one of the major gastrointestinal problems around the globe and its effects greatly on individual health, quality of life, social life, and economy. This study is aimed to determine GERD prevalence, risk factors, and management. Methods: It was a cross-sectional study carried out using a validated questionnaire. The data was collected from the general population. The questionnaire consisted of demographic information, personal and habitual data, GERD Questionnaire. The Chi-Square test was used to find the association. Results: The prevalence rate of GERD was found to be about 31%. There was a significant association between GERD and sociodemographic variables such as older age, obesity, profession, do not exercise daily, skipping breakfast, intake of alcohol, fast food, and dinner timing within 1 hour of bedtime, history of illness, family history of GERD, and medication history. The population used both pharmacological and non pharmacological methods of management. The most common method for managing GERD symptoms used by 21.6% of the population was non-prescription or OTC drugs, other methods used...
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Posted by admin on Sep 30, 2023 in |
Background: Stroke is the most frequent clinical manifestation of diseases of the cerebral blood vessels. Up to 90% of post-stroke survivors report one or more disabilities, including impaired walking. Physical rehabilitation and gait training with equipments are essential in the management of post stroke gait disability, however, these techniques are not amenable for hemiplegic patients because of their limitations to actively participate in such training programs. Unani (Greco-Arab) Medicine scholars have been known to treat post-stroke complications on concept of Tanqiya (elimination of morbid matter) and Ta’deel (revitalization of diseased organ) since centuries. Methods: The study was conducted as open, interventional clinical trial, enrolling 30 eligible patients. Tanqiya was done by Mundij (coctives) and Mus’hile Balgham (phlegm purgatives) drugs used in decoction form for 13 days; after Tanqiya, full body Inkibab (steam bath) with Advia Harrah (Hot temperament Drugs) was started from 14th to 28th day of the study for the purpose of Ta’deel. Assessment for gait improvement was performed on valid and reliable scale “FAC” at baseline, 14th...
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Posted by admin on Sep 30, 2023 in |
Introduction: This study aimed to compare the efficacy and safety of insulin degludec with insulin glargine in patients with type 1 and type 2 diabetes. Methods: We systematically searched PubMed, Embase, Web of Science, and Cochrane Library databases for randomized controlled trials published prior to July 2019 (no language restrictions) which compared insulin degludec with insulin glargine. Our main endpoints were glycemic control, and hypoglycemic events. We assessed pooled data using random-effects models. Results: A total of 20 studies that included 22706 patients, 11929 in the insulin degludec arm of the studies and 10777 patients in the insulin glargine arm were identified and subsequently assessed. Our analysis showed that compared with insulin glargine, insulin degludec yielded an improved mean reduction in fasting plasma glucose (FPG) (MD – 6.747, 95% CI – (1.702 to 11.79), p = 0.013), improved mean reduction in glycosylated hemoglobin (HbA1c) (MD 0.095, 95% CI –(-0.155 to -0.035), p = 0.867) and a lower ratio of participants experiencing the severe hypoglycemic event and nocturnal hypoglycemia (95%...
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Posted by admin on Sep 30, 2023 in |
The drug of dendrigel, uses dendrimers as medicine carriers. Dendrimers were prepared by divergent growth techniques and were loaded in varying quantities in carbapol 934. To this mixture, itraconazole drug was added and the expression of dendrigel was estimated. Dendrimers were prepared by divergent growth techniques. Estimation parameters like color test, UV spectroscopy, and FTIR. Evaluation parameters for dendrigel were pH, spreadability, thickness, drug content, antifungal exertion, and in vitro release studies. The set dendrigel has better antifungal exertion than another transdermal medicine delivery system because dendrimers enhance the drug’s solubility, which increases the penetration of the drug in the skin. In the present study, an attempt was made to develop dendrimers containing itraconazole as a drug to increase the solubility and penetration of the drug through the skin using the new delivery system for better antifungal application. This will help to increase the solubility and penetration of the drug. It increases the antifungal application of the...
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