Different doses of Ethanolic fraction of Ribes nigrum fruit were evaluated for hypoglycemic activity in Alloxan induced diabetic rats. The oral administration of Ethanolic extract at a dosage of 100mg/kg and 500mg/kg body weight exhibited significantly reduced the serum glucose level in both acute (1, 3, 5 h) and sub-acute (1, 3, 5, 7 days) treatments. Perform the Histopathological study of...
Read MoreIn the present study, three medicinal plants Cynodon dactylon (L.) Pers, Cassia tora Linn. and Cassia alata Linn having significant anti-inflammatory potential were selected to be formulated as polyherbal gels. The gels were prepared using the dried methanolic extract of Cassia tora Linn, Cassia alata Linn and Cynodon dactylon (L.) Pers. Polyherbal gel formulations were evaluated for its pH, appearance and homogeneity, viscosity, spreadability and skin irritation studies. Assessment of Anti-inflammatory activity was done by carrageenan induced rat paw edema and formalin- induced rat paw edema. Individual and polyherbal gel of Cassia alata Linn,Cassia tora Linn. and Cynodon dactylon (L.) Pers were found to possess anti-inflammatory effect in acute and chronic models. Polyherbal gel also showed synergistic effect as compared to individual gels which can be useful for the treatment of local...
Read MoreAn accurate, precise and reproducible high performance liquid chromatographic method was developed for quantitative estimation of hydrochlorothiazide in tablet dosage forms. Chromatographic separation of the drug was achieved on a Kromasil C18 column (150 x 4.6 mm; 5µ) using a mobile phase consisting of phosphate buffer (pH 2.5) and acetonitrile (50:50 v/v) at a flow rate of 0.6 mL/min. The drug in the eluate was monitored at 254 nm. The retention time obtained for the drug was 3.47 min. The calibration curve was linear over the range of 20-60 µg/mL of the drug. The performance of the method was validated according to ICH guidelines. The method could be applied for determination of hydrochlorothiazide in its tablet dosage forms without any interference from excipients or endogenous substances. The proposed method is suitable for routine quality control analysis of...
Read MoreThe antioxidant activities of five wild leafy vegetables e.g. Allium porrum, Carpesium cernuum, Tricyrtis pilosa, Spilanthes acmella, and Leea sambucina collected from Meghalaya state in India were determined by using 1,1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging activity, reducing power ability, estimation of total phenolic content, flavonoid content and flavonol content.. The results indicate that these wild edible plants can be utilized as natural antioxidant. The solvent systems used were benzene, chloroform, acetone and methanol. The different levels of antioxidant activities were found in the solvent systems used. The results indicate that these wild edible vegetables can be utilized as natural...
Read MoreThe objective of the current study was to design an oral sustained release matrix tablet of Ramipril and to evaluate the effect of polymer on release pattern of the drug. Tablets were prepared by direct compression method using Methocel (Hydroxy Propyl Methyl Cellulose) K100MCR and Methocel (Hydroxy Propyl Methyl Cellulose) K4MCR, as matrix forming polymer. Dissolution studies were carried out in 500 ml phosphate buffer (pH 6.5) for 8 hours. The release mechanism was explored with zero order, first order, Higuchi equation and Korsmeyer’s equation. The drug release followed Higuchi equation. It was found that the release of drug from matrix tablet decrease with the increasing of percentage of polymer. The two high viscosity polymers (Methocel K4MCR and Methocel K100MCR) were found suitable for the...
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