Posted by admin on Jan 1, 2013 in |
Cough is a natural reflex expulsive defense mechanism of the body, for clearing excess secretions, mucous, inhaled irritants, toxins or foreign substance in the respiratory tract.It is the most common symptom of respiratory disease. When cough becomes serious, opioids are effective, but they have side effects like sedation, constipation, some addiction liability and also compromise the respiratory function. Therefore, there is a need to have effective anti-tussive agent which do not have respiratory suppressant activity. The present study was carried out to evaluate anti-tussive activity of leaves of Caesalpinia bonducella in ammonium hydroxide induced coughmodel in...
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Posted by admin on Jan 1, 2013 in |
Tribulus terrestris L. (TT; Zygophyllaceae) is employed in the folk medicine against sexual impotence, oedemas, abdominal distention and cardiovascular diseases. Gastroprotective (i.e. antiulcer and anti-secretory) potential of methanolic extract of TT fruits was evaluated in pylorus-ligated rat model of Wistar rat. The methanolic extract of TT was tested orally at the doses of 150, 300 & 600 mg/kg, on gastric ulcerations experimentally induced by pylorus ligation. Preliminary phytochemical screening of the methanol extract of TT showed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, tannins and proteins. The methanolic extract at the doses of 300 & 600 mg/kg produced more significant inhibition when gastric ulcerations were induced by pylorus ligation respectively. The methanol extract of the fruits of Tribulus terrestris L. possess gastroprotective i.e. antiulcer and anti-secretory...
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Posted by admin on Jan 1, 2013 in |
The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared and characterized for hardness, friability, thickness, uniformity of weight, drug content, disintegration time, In-vitro dissolution studies. Formulation (AFD5) was found to be better formulation in terms of rapid disintegration and maximum percentage of drug release compared to other...
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Posted by admin on Jan 1, 2013 in |
A simple, sensitive, highly accurate UV spectrophotometric method has been developed for the determination of mesalamine in bulk and tablet dosage form. Solution of mesalamine in distilled water shows maximum absorbance at 330 nm. Beer’s law was obeyed in the concentration range of 2-16 μg/ml with the slope, intercept, correlation coefficient, detection and quantitation limits were also calculated. The proposed method has been applied successfully for the analysis of the drug in pure and in its tablets dosage forms. Result of percentage recovery and placebo interference shows that the method was not affected by the presence of common excipients. The method was validated by determining its sensitivity, accuracy and precision which proves suitability of the developed method for the routine estimation of mesalamine in bulk and solid dosage form. The method was then validated for different parameters as per the ICH (International Conference for Harmonization) guidelines. Mesalamine was subjected to stress degradation under different conditions recommended by ICH. The samples generated were used for degradation studies using the developed...
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Posted by admin on Jan 1, 2013 in |
Lamivudine, a BCS Class I synthetic nucleoside analogue, has a a short biological half-life of 5–7 and is mainly absorbed in the upper gastrointestinal tract. The purpose of the study is to develop a controlled release floating tablets of lamivudine employing HPMC K4M and sodium alginate. The floating tablets of lamivudine were prepared employing HPMC K4M and sodium alginate as matrix formers and sodium bicarbonate as an effervescent agent. The tablets formulated were evaluated for tablet weight variation, drug content uniformity, hardness, friability, floating behaviour and in-vitro drug release. All the formulations fulfilled the official requirements for tablet weight variation, drug content uniformity, hardness and friability. Tablets formulated by using a combination of HPMC K4M/sodium alginate and HPMC K4M alone gave a lesser floating lag time when compared with tablet formulated with sodium alginate alone. All the tablets were found to remain buoyant in 0.1N HCl for a period >24h. The drug release from the prepared tablets was found to be diffusion controlled and followed first order kinetics. Non-Fickian...
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