Posted by admin on Mar 1, 2013 in |
Background: In Ethiopia 10.6% and Addis Ababa, 30% of the population has been estimated to have hypertension. Adherence to medication therapy and lifestyle change is an aspect of patients’ care that is often overlooked and should be evaluated as a crucial part of cardiovascular management. Objective: The aim is to assess adherence and influencing factors of adherence to hypertensive management among hypertensive patients in Black Lion Hospital chronic follow up unit, Ethiopia. Methods: A cross-sectional study was conducted. Systematic sampling technique was used to select 286 study subjects. A structured standard interviewer administered questionnaire was used after some modifications. Analysis was done using SPSS 16. P-value <0.05 was considered significant association. Scoring method was used to classify patients’ level of adherence. Results: Of 286 subjects included in the study 165(57.7%) were female and mean age was 52±13 year. The adherence level of respondents to medication, diet and exercise were 69.2%, 64.7%, and 43.7% respectively. The medication and diet related adherence were found to be better in patients who had...
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Posted by admin on Mar 1, 2013 in |
Candesartan was degraded together under different stress test conditions prescribed by International Conference on Harmonization. The samples so generated were used to develop a stability-indicating high performance liquid chromatographic (HPLC) method for the candesartan. The drug was well separated from degradation products using a reversed-phase (C-18) column and a mobile phase comprising of Acetonitrile: Buffer (80:20 v/v) at pH- 3. Other HPLC parameters were: flow rate, 1 mL/min; detection wavelength, 225 nm; and injection volume 20 µl. The method was validated for linearity, precision, accuracy etc. Results obtained after validation study, indicating that the proposed single method allowed analysis of Candesartan, in the presence of their degradation products formed under a variety of stress conditions. The developed procedure was also applicable to the determination of stability of the drug in commercial pharmaceutical dosage...
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Posted by admin on Mar 1, 2013 in |
Background: Two primary species of Mimusops are Mimusops elengi and Mimusops hexandra. Leaves of both species are traditionally used in several ailments. However, it is difficult to distinguish the leaves of the species. Objectives: The present investigation deals with the comparative pharmacognostical study of the leaves of the two species and establishment of its quality parameters. Methods: Detailed morphological and qualitative as well as quantitative microscopic study was carried out. This was followed by phytochemical screening and estimation of tannins in the two species. Results: The important diagnostic feature of powder of both leaves include pericyclic fibers, rosette and prism shape calcium oxalate crystals and resinous matter. The leaves show significant difference in their quantitative microscopic parameters as well as their tannin content. Conclusion: The present work can serve as a useful tool in the identification, authentication and standardization of the plant material and distinguishing the two species from each...
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Posted by admin on Mar 1, 2013 in |
Oxygen is an element obligatory for life. Biological combustion produces harmful intermediates called free radicals. Free radicals are continuously produced by the body’s aerobic life and our metabolism. Antioxidants are the substances, which act against oxidative compounds. Under normal conditions the body’s antioxidants convert ROS to prevent the over production of free radicals. Recently, natural foods and food derived antioxidants such as vitamins and phenolic phytochemicals, have received growing attention, because they are known to function as chemo preventive agents against oxidative damage and are considered beneficial for human health. The present study was conducted to compare the antioxidant activity of fresh and dry rhizomes of Curcuma zedoaria. The methanol extract of both the rhizomes showed good radical scavenging...
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Posted by admin on Mar 1, 2013 in |
Background: Black tea is rich in polyphenols which are antioxidants. The most abundant polyphenolic compounds are flavonols and catechins. Black tea antioxidants showed protective actions against chronic diseases like cardiovascular diseases due to their antioxidant action. Objective: The present study was conducted to evaluate the cardioprotective effects of Camellia sinensis on isoproterenol induced myocardial infarction in Wistar albino rats. Myocardial infarction (MI) is a condition in which a part of the heart muscle suddenly loses its blood supply, so the myocardium gets destructed and becomes ischemic. Camellia sinensis is a species of plant from which leaves and leaf buds are taken to produce tea. Myocardial infarction was induced by subcutaneous administration of Isoproterenol. Isoproterenol shows positive inotropic and chronotropic effects on heart. Oxidative products of drug cause cytotoxicity and myocardial damage. Methods: Wistar albino rats were divided into 8 groups, each group containing 8 rats. The following treatment was given for 21 days. Group 1: NS 1mg/kg (orally). Group 2: NS+ISO (85 mg/kg, s.c.). Group 3: BTE 1 (4mg/kg,...
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