Posted by admin on Dec 1, 2012 in |
In present study, a series of new synthesized condensed pyrazole derivatives 1a-f have evaluated in vitro for their antioxidant activity, reducing power ability, antibacterial activity against Gram-positive and Gram-negative organisms and antifungal activity against different organisms. Minimum inhibitory concentration against the bacterial and fungal strains was determined. The study provides the structural impact of the compounds for their biological...
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Posted by admin on Dec 1, 2012 in |
Synthesis of chalcone derivatives was carried out by aldol condensation, these 2’-hydroxychalcones were cyclized to 3-hydroxyflavone and 2, 3- dihydroflavan-3-ol derivatives and we also report here there in vitro antiplaque activity. Most of the synthesized compounds were found to be active against Streptococcus mutans. Activity of two 3-hydroxyflavones was found to be higher than that of their corresponding 2, 3- dihydroflavan-3-ol derivatives and chalcone analogues. Investigated compounds having hydroxy group substituents in ring-B exhibited enhanced activity and the presence of electronegative groups in the studied compounds showed a direct relationship to the antiplaque...
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Posted by admin on Dec 1, 2012 in |
Significant increase in the salivary gland lipid peroxidation, fluorescence product as well as accumulation of lipofuscin granules–age pigment was observed after injection of 5% D-galactose 0.5 ml daily for 30 days. Supplementations of turmeric extract (30mg/kg body weight) for 30 days during and after D-galactose treatment significantly reduced all the above parameters. Histochemical changes in the form of accumulation of age pigment were observed in the submandibular gland (SMG) of experimental animals. The normalization of levels of all the studied parameters in the SMG by curcumin supplementation in D-galactose induced aging accelerated mice is suggestive of the possible ameliorating effect of curcumin on SMG. While in curative group II the levels of all parameters were elevated as compared to D-galactose treated group...
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Posted by admin on Dec 1, 2012 in |
Aim of the study: The present study was designed to investigate the analgesic and antidiarrhoeal activities of the ethanolic extract from the bark of Manilkara zapota (Linn.). Material and methods: The analgesic activity was evaluated in acetic acid induced writhing model and the antidiarrhoeal activity was evaluated in castor oil induced diarrhoea model in white albino mice (Swiss-webstar strain). Resuts: Phytochemical analysis of the ethanolic extract of the bark of M. zapota indicates the presence of reducing sugar, tannins, steroid, saponins & gum of compounds. The ethanolic extract of M. zapota has effect on acetic acid induced writhing in mice. At the dose of 250 mg/kg & 500 mg/kg of body weight, the extract produced 38.55% & 56.42 %writhing inhibition in test animals respectively. The results are statistically significant (P <0.001) and is comparable to the standard drug Diclofenac Na, which showed 72.07% at a dose of 25 mg/kg weight. The extract has also effect on castor oil induced diarrheal method in mice. The result show that extract inhibited...
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Posted by admin on Dec 1, 2012 in |
This paper describes the utilization of pteridophytes for the treatment of various gynecological and other related problems by the indigenous women of Pachmarhi Biosphere Reserve in Madhya Pradesh. The present study reveals that 23 species of pteridophytes belonging to 15 families and 18 genera are traditionally used by tribal women of Korku, Gond, Bharia, Bhil, Mauria, Maria, Paria, Bhatara and Baigas communities in gynecological problems which contribute about 18.66% of total pteridophytic diversity (134 species) of the...
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