Posted by admin on Feb 1, 2013 in |
Capsaicin, the pungent ingredient of red pepper, is used topically to treat different types of neuropathic pain, in rat model of vincristine induced neuropathic pain we tried to investigate the effect of capsaicin on sciatic nerve through electrophysiological and histopathological studies. We found that treatment of animals with vincristine results in significant decrease in sciatic nerve conduction velocity and degeneration of the nerve fibers, where combined treatment of vincristine and capsaicin showed highly significant decrease in sciatic nerve conduction velocity and degeneration of the nerve fibers compared with that treated with vincristine only. In new trial, we tried to investigate the effect of direct capsaicin titration on sciatic nerve fibers that results in nearly abolishment of nerve conduction velocity. All of these findings may illustrate the mechanism of capsaicin effect through afferent nerves...
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Posted by admin on Feb 1, 2013 in |
Decrease in blood glucose level test with the use of oral glucose tolerance method from Avocado leaves was carried out. Swiss Webster male mice were divided randomly into five groups. They were negative control, positive control (Glipizide 0.013 mg/20 g BW) and three test groups treated with dosage of avocado leaves ethanol extract 0.490 g/kg, 0.980 g/kg and 1.960 g /BW respectively. Experiment was begun with feeding the mice with the test solution followed by feeding glucose solution (1.5 g/kg BW) 30 minutes later. Blood glucose levels were assessed using glucometer kit, from zero to 3 hours, at ½ hourly interval. These results analysed by one way ANOVA showed there were significant difference (p<0.05) between Ethanol extract of avocado leaves treated with mice (0.490, 0.980 g/kg BW) and control groups.Furthermore, when Tukey’s test was performed, avocado treated mice (1.960g/kg BW) reduce glucose level to 64.27%. The effectiveness of this treatment was not significantly different to those treated with glipizide...
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Posted by admin on Feb 1, 2013 in |
Background– Breastfeeding and good nutrition for children are essential for achieving the Millennium Development Goals, particularly the goals relating to child survival. Even though, most mothers in Ethiopia breastfeed their babies, they do not always follow the recommendations of the “National Strategy for Infant and Young Child Feeding”. Objective– The aim of this study was to assess determinants of breastfeeding practices among mothers’ of children aged less than 24 months attending governmental maternal and child health clinics in Mekelle town. Methods– Institution based cross sectional study was carried out among five health facilities selected using simple random sampling technique. Data was collected by interviewer administered structured questionnaire and it was entered, cleaned and analyzed by using SPSS for windows version 16.0. The proportion was used to describe the results and it was presented in the form of figures, tables and texts. The binary logistic regression model was used to test the association between dependent and independent variables. Result– A total of 361 mothers with their index child were interviewed. ...
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Posted by admin on Feb 1, 2013 in |
Tuberculosis is an infection bacterial disease caused by Mycobactrium tuberculosis, which most commonly affects the lung, it can be treated with Anti-TB drug which are classified into first and second line drug classes where the treatment regimen consists of two phases: the initial phase and the continuation phase. Isoniazid is one of the most important first line drugs for the treatment of tuberculosis and several methods have been reported to describe the quantitative determination of isoniazid, include the derivatization of isoniazid with several aldehydes to form the corresponding Schiff’s base. The aim of this study is to find a new spectrophotometric method for isoniazid (INH) analysis that combined the previously mentioned derivatization (hydrazone formation) with microwaves synthesis in order to achieve more accurate, rapid and simple method. The use of the microwaves to accelerate and quantitatively complete the reaction between isoniazid and the aldehyde is the most important modification we suggest in comparison to other previously mentioned method. Seven isoniazid Schiff’s bases of several aldehydes subjected to our investigation...
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Posted by admin on Feb 1, 2013 in |
An ongoing, systematic process designed to maintain the appropriate and effective use of drugs is Drug Use Evaluation (DUE). It involves a comprehensive review of patient’s prescription and medication data before, during, and after dispensing in order to assure appropriate therapeutic decision making and positive patient outcomes. The aim of the present study is to conduct a prospective study on utilization pattern of antibiotics in the department of medical teaching hospital situated in North Karnataka to evaluate the rational use of antibiotics, by comparing with the standard Clinical guidelines. The study is a Prospective observational with a sample size of 250 patients conducted using structured data entry forms. In our study, 155 patients were male and 95 were female. The most commonly used class of antibiotics are Cephalosporins (31.2%) preceded by Fluoroquinolones and Azoles. Penicillin’s were also prescribed for most of the infectious diseases. The duration of hospital stay is for more than 7 dayswith prolonged use of antimicrobial agents which does not provide an additional therapeutic benefit while the...
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