Posted by admin on Dec 1, 2012 in |
The kinetics of oxidation of amitriptyline by potassium permanganate in aqueous sulphuric acid medium at 298K and at a constant ionic strength of 0.20 mol dm-3 has been investigated spectrophotometrically. The reaction exhibits 5:4 stoichiometry (5 Amitriptyline:4 KMnO4). The reaction was first order with respect to manganese(VII) concentration. The order with respect to amitriptyline was found to be less than unity (0.80). Increase in acid concentration increased the rate. The order with respect to acid concentration was also less than unity (0.40). The effect of added products, ionic strength and dielectric constant has been studied on the rate of reaction. The oxidation products were identified by using 2, 4 DNP derivative, IR, GCMS spectral studies. A suitable mechanism was proposed on the basis of experimental results. The reaction constants involved in the different steps of the reaction mechanism were calculated. The activation parameters with respect to slow step of the mechanism was determined and...
Read More
Posted by admin on Dec 1, 2012 in |
Cyperus rotundus Linn. (Cyperaceae) is an indigenous medicinal plant used for the treatment of pain, inflammation, diarrhoea, tumours, wounds and as Antidiabetic Anticonvulsant, Antimicrobial, Antiallergic, Antioxidant and Antiarthritic. The methanolic extract of rhizome was subjected to anti-inflammatory activity using experimental animal model of carrageenan induced paw edema in the presence of control for comparison. The results showed that methanolic extract significantly ameliorate oedema comparable to reference standard, Indomethacin. The results of this study explicate justification of the use of this plant in the treatment of inflammatory disease...
Read More
Posted by admin on Dec 1, 2012 in |
Evolvulus aslsinoides is being used in traditional medicine for the treatment of severe bronchitis and asthma. So the aim of study was to evaluate antioxidant and antiasthmatic activity of ethanol extract of Evolvulus aslsinoides leaves. The present investigation was undertaken to evaluate the histamine-induced bronchospasm of alcoholic extract of Evolvulus aslsinoides leaves in experimental animals. Bronchodilator activity of aqueous extract of Evolvulus aslsinoides leaves studied on the histamine aerosol induced bronchospasm in wister rats. Treatment with alcoholic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o) showed significant protection against histamine aerosol induced bronchospasm in wister rats. The results of the histamine-induced bronchospasm paradigms demonstrate bronchospasmolytic activity of ethanolic extract of Evolvulus aslsinoides leaves (250 mg/kg, p.o.). Evolvulus aslsinoides leaves shows 41.49% protection against histamine induced bronchoconstriction in rats. These results suggest that aqueous extract of Evolvulus aslsinoides leaves has not only bronchodilating activity but also decreases bronchial hyperreactivity by decreasing the infiltration of inflammatory cells in the airway and inhibition of release of histamine like mediators from the mast cell...
Read More
Posted by admin on Nov 1, 2012 in |
Various 1-(substituted benzylidene)-5-(3-hydroxyquinoxaline-2-yl) carbonohydrazide were synthesized starting from orthophenylenediamine. Structures of all the compounds were confirmed on the basis of spectral analyses. All the newly synthesized compounds were screened for anticonvulsant activity. Some of the compounds showed significant anticonvulsant activity with no...
Read More
Posted by admin on Nov 1, 2012 in |
Crossandra infundibuliformis belonging to family Acanthaceae is well known medicinal plant in various region of India. This plant is one of the most chosen variety for folk medicine. Flower extract used in various conditions like fever, headache, aperitif, pain etc. Present study is concern mainly with evaluation of wound healing activity of flower ethanolic extract in Wistar rats using excision wound model in the form of ointment using two concentrations (2 and 4%w/w ointment) of flower extract in simple ointment base. Both concentration of ethanolic extract showed significant response in both the wound type tested when compared with control group. 4% w/w concentration has showed better significant value than the standard drug. Nitrofurazone ointment (0.2%w/w) was used as standard...
Read More
