Posted by admin on Dec 1, 2012 in |
High Blood pressure or hypertension is one of the most ubiquitous yet nettle some medical problems that physician and health care provider face in the office. In present study amlodipine and cilnidipine have been selected to evaluate and compare their efficacy and tolerability in mild to moderate essential hypertension. 60 patients of uncomplicated mild to moderate essential hypertension were evaluated for clinical efficacy, effect on biochemical parameters and side effects in 6 weeks of treatment. They were divided into 2 groups of 30 patients each, making a total of 60 patients. First group of 30 patients was given cilnidipine 5-20 mg/day and second group of 30 patients was given amlodipine in dose of 5-10 mg/day and dose was adjusted according to control of blood pressure. In the present study, it was clearly evident that cilnidipine and amlodipine both are effective antihypertensive drugs. Both the drugs were instrumental in decreasing systolic blood pressure significantly (p<0.05).. Both the drugs also decreased the diastolic blood pressure significantly (p<0.05). There was no significant...
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Posted by admin on Dec 1, 2012 in |
Three N,N’-diacyl-2,6-diaminopyridines were synthesized with a saturated undecanoic acid or an unsaturated undecenoic acid in order to study the effect of the alkyl-chain on the nano architectures. The imaging studies showed that the compound possessing two unsaturated alkyl chains exhibited a tubular structure. On the other hand compound possessing two saturated alkyl chain showed poorly formed nanotubes and the compound with one saturated and one unsaturated alkyl chain formed nanosheets. These results indicate that the morphology is strongly dependent on the alkyl...
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Posted by admin on Dec 1, 2012 in |
Cardiospermum halicacabum L. var. microcarpum (Kunth) Blume and var. luridum (Blume) Adelb. (Sapindaceae) are used for various ailments in Indian traditional medicines. The present study evaluated the antiulcerogenic property of seed oils (Petroleum ether extracts) in animal model. Ethanol induced gastric ulcers was used for this study and analysed for gastric volume, ulcer score pH, free and total acidity and sodium and potassium ions. Bio-chemical estimations like total proteins, total hexoses, hexosamine, fucose, sialic acid and protein were also made. Ulcer score was calculated for the same model. Oils were found to be more effective and exhibit concentration dependent anti-ulcer...
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Posted by admin on Dec 1, 2012 in |
A simple, precise and accurate UV-Spectrophotometric method has been developed and validated for estimation of Efavirenz in bulk and tablet dosage form. It shows maximum absorbance at 320 nm with methanol and water (30:70). Estimation was carried out by A(1%1cm) and by comparison with standard. Calibration graph was found to be linear (r2 =0.09657) over concentration range of 1-4μg/ml. The proposed methods appear to be simple, sensitive, and reproducible when checked for parameters like accuracy, precision, limit of detection for routine determination of Efavirenz in bulk as well as in tablet. The methods can be adopted in its routine...
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Posted by admin on Dec 1, 2012 in |
The main aim of our study is to evaluate the antiurolithiatic activity of pomegranate (punica granatum, Family: Puniaceae) and garlic (Allium sativum, Family: Liliaceae). For this, we have subjected the seeds of pomegranate and garlic bulbs to maceration using 95% of ethanol, ethyl acetate, petroleum ether and water at a ratio of 1:4 for 24 hours, followed by reflux over a water bath for 3 hours and the obtained extract was concentrated under vacuum. The prepared extracts were then subjected to titrimetry and colorimetry for the estimation of calcium and phosphate respectively. By comparing the result of different extracts, we have found that ethanol extract of garlic has showed better result in inhibiting precipitation of calcium and phosphate. But individual isolation and further studies are to be carried out to confirm this...
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