Posted by admin on Nov 1, 2012 in |
Trichosanthes dioica Roxb (family: Cucurbitaceae), commonly known as “Sespadula” in English and “Parwal” in Hindi and is widely grown throughout India. The leaves of this plant have also been used in traditional system of medicine for overcoming problems like constipation, fever, skin infection, wound healing and also in gastric ulcer. In the present study Aqueous extract of leaves of Trichosanthes dioica Roxb was evaluated for its antiulcer activity against; 1) Aspirin plus pylorus ligation model and, 2) Ethanol/HCl-induced ulcer in wistar rats. Ranitidine (100 mg/kg) was used as the standard drug. Different groups of rats (n=6 in each group) were given two doses (250 and 500 mg/kg) of T.dioica extract. Phytochemical analysis of the extract was also done. Phytochemical results revealed presence of tannins, saponins, triterpenoids, flavanoids. Thus only T.dioica extract (500 mg/kg) significantly (p<0.001) reduced the ulcer index in all the models used. The extract also significantly (p<0.001) increased the pH of gastric acid while at the same time reduced the volume of gastric juice, free and total...
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Posted by admin on Nov 1, 2012 in |
Ethanol extracts of Naringi crenulata leaf and bark were evaluated for its anti-inflammatory activity at the dose levels of 250mg kg-1 and 500mg kg-1 body weight using a Carrageenan induced paw oedema method (acute inflammation). Results showed that both leaf and bark ethanol extracts had potent and significant anti-inflammatory activity. These results were also comparable with reference drug indomethacin used in this...
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Posted by admin on Nov 1, 2012 in |
Aim of study: In this study, we investigate the potential effect of Nyctanthes arbortristis leaf extract in experimentally induced asthma in rats. The leaf has shown the prominent effect against the inflammation. Materials and methods: Asthma was induced experimentally in rats using Sephadex and in another model croton oil was applied on ear of rats; this model also mimics the biological event similar to asthma. Results: The results demonstrated that the Sephadex induced lung inflammation and croton oil induced ear edema both were palliated by the Nyctanthes arbortristis leaf extract given to the rats. The prophylactic effect of the leaf extract was evaluated by the lung weight and histological examination and investigation of oxidative and anti-oxidant markers in lung tissues. Conclusions: This study demonstrated for the first time that ethanolic leaf extract of Nyctanthes arbortristis (ENAL), was effective in prevention of experimentally induced asthma in rats. In vivo data indicated that ENAL were as much effective as Fluticasone propionate i.e. standard drug used to treat asthma which might be...
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Posted by admin on Nov 1, 2012 in |
Carboxymethyl chitosan, a water soluble modified carboxymethyl substituted chitosan derivative have distinct and unique properties, rendering them effective to form selective permeable mucoadhesive film or membranes. In the formulation of chitosan microsphere an acidic environment is essentially required that may degrade acid sensitive moiety, peptide or protein drugs. Mucoadhesive microparticle of carboxymethyl chitosan was designed and developed for site specific sustained release of Pantoprazole sodium. Thus prolong the residence time at the absorption site by intimate contact with the mucus layer thereby increase bioavailability, reduce the frequency of dose administration and also prolong the drug release. The mucoadhesive microparticles were prepared by Orifice ionic gelation method using carboxymethyl chitosan in combination with Carbopol 934 and HPMC K15. Entrapment efficiency was in the range of 42.4 to 84.6 %. SEM studies revealed that microparticles were discrete, spherical and free flowing. Microparticle exhibited good mucoadhesive property in the in vitro wash off test and found that Carbopol 934 had greater mucoadhesive strength than that of HPMC K15. A sustained release of...
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Posted by admin on Nov 1, 2012 in |
The present study deals with investigating the effect of chitosan nano particles as carriers for an anticancer drug curcumin. The chitosan-curcumin nanocapsules were prepared in the presence and absence of gold nanoparticles via solvent evaporation method. Scanning electron microscopy and transmission electron microscopy was done to characterize the drug entrapped nanocapsules. The average diameter of gold nanoparticles was found to be in the range of 18-20 nm and size of the nanocapsules was found to be in the range of 200-250 nm. Fourier transform-infrared analysis revealed no possible interactions among the constituents with the chitosan nanoparticles. The controlled drug release of anticancer drug entrapped nanocapsules was carried out in 0.1M HCl and 0.1M phosphate buffer (pH 7). Experimental studies revealed that curcumin encapsulated chitosan with gold nanoparticles was controlled and steady when compared with curcumin encapsulated chitosan nanoparticles. Application of in vitro drug release date to various kinetic equations indicated higuchi matrix model indicating uniform distribution of curcumin in the...
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