Posted by admin on Nov 1, 2012 in |
Povidone-Iodine Ointment was prepared using polyethylene glycol base by fusion method and the gel was prepared using Poloxamer 407 as a gelling agent by cold process. The different characteristics of povidone-iodine ointment and gel were compared from the results obtained for assay and total, available and complex iodine contents. These values were comparable with marketed formulations. The formulations were tested for wound healing and antimicrobial activity. Wound healing studies show that the time taken for complete wound healing was slightly less for prepared povidone-iodine ointment and gel than the marketed preparations. Antimicrobial activity also found to be almost equal for the different...
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Posted by admin on Nov 1, 2012 in |
Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Several difficulties are faced in designing controlled release systems for better absorption and enhanced bioavailability. To overcome the problem of conventional dosageforms ofloxacin effervescent floating tablets were developed in six different formulations (F1 to F6) by employing different grades of polymers and effervescent agent sodium bicarbonate. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug release mechanisms. F6 formulation showed good physical parameters and gave slow and maximum drug release of ofloxacin spread over 24 hours and showed maximum similarity with marketed product in dissolution profile. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and...
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Posted by admin on Nov 1, 2012 in |
Cayratia trifolia (Linn.) Domin (Vitaceae) is a perennial climber, commonly known as fox grape in English, Amalbel, Ramchana in Hindi and Amlavetash in Sanskrit, found in India, Asia and Australia. The infusion of seeds along with extract of tubers is used traditionally for the treatment of diabetes. Whole plant is used as diuretic, in tremors and splenopathy. It is reported to possess antiviral, antibacterial, antiprotozoal, hypoglycaemic, anticancer and diuretic activity etc. The present study was carried out to establish the pharmacognostical studies, physico-chemical parameters along with preliminary phytochemical screening of petroleum ether, chloroform, methanolic and aqueous extracts of Cayratia trifolia (Linn.) Domin. The macroscopical and microscopical characters were studied. The transverse section (T.S.) of stem indicated the arrangement of various cells in cork, cortex, phelloderm and pith region. The histochemical color reaction of T.S with different chemical reagents and preliminary phytochemical screening of various extracts revealed the presence of carbohydrate, flavonoids sterols, phenolic & tannins compounds. The physico-chemical parameters such as total, acid insoluble, water insoluble and sulphated ash...
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Posted by admin on Nov 1, 2012 in |
Various 1-(substituted benzylidene)-5-(3-hydroxyquinoxaline-2-yl) carbonohydrazide were synthesized starting from orthophenylenediamine. Structures of all the compounds were confirmed on the basis of spectral analyses. All the newly synthesized compounds were screened for anticonvulsant activity. Some of the compounds showed significant anticonvulsant activity with no...
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Posted by admin on Nov 1, 2012 in |
The purpose of this study was to investigate the experimentally possible antitumor effect and antioxidant role of methanolic extract of Tabebuia rosea leaves against Dalton’s ascetic lymphoma (DAL) induced Swiss albino mice. The methanolic extract of Tabebuia rosea (METR) was administered at the doses of 100mg/kg, 200mg/kg in mice for 14 days after 24hours of DAL inoculation. The effects of METR on the growth of bodyweight, MST, viable and nonviable cell count, Tumor volume, Packed Cell Volume (PCV), life span of DAL bearing mice were studied. Hematological profile and liver biochemical parameters (lipid per oxidation, antioxidant enzymes) were also estimated. Treatment with METR decreased the tumor volume and viable cell count thereby increasing the lifespan of DAL bearing mice. Alteration in the Hematological parameters, protein, PCV occurred because of DLA inoculation, were almost restored in METR treated groups. The effect of METR also decreases the levels of lipid peroxidation and increases the levels of glutathione (GSH), superoxide dismutase (SOD), and catalase (CAT). The histopathological results showed the loss of...
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