Posted by admin on Jan 1, 2013 in |
The aspire of the present research was to explore the hypoglycemic, analgesic and anti-inflammatory activity of ethyl acetate extract of Peporemia pellucida in alloxan-induced diabetic mice, Acquired immune deficiency syndrome (AIDS), and hypercholesterolemia and against pain. In the present study hypoglycemic effect of the ethyl acetate extract of Peperomea pellucida was significant from (25.35 to 8.1 mM ±SEM) i.e., 68.44% in 300mg/kg ethyl acetate extract as a 7 days hypoglycemic treatment. On 120 minutes OGTT test, reduction of blood glucose level was also significant. In 300mg/kg extract blood glucose level reduced from (20.53mM to 7.69 ±SEM) 62.64% was observed. Analgesic treatment was observed carefully and mentionable activities were evaluated. Percentage of inhibition was 58.16 with the number of writhing 11.8±SEM in 300mg/kg inhibition was observed with 6.8 ±SEM writhing. P. pellucida has significant anti-inflammatory effect after 4 hr with 3.47± SEM. The present study indicates significant hypoglycemic, analgesic and anti-inflammatory effects of P. pellucida. The present investigation established the pharmacological evidence to support the folklore claim and that of...
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Posted by admin on Jan 1, 2013 in |
In the present research work, diethyl malonate and phenyl hydrazine were reacted together to give pyrazolidine-3,5-dione nucleus which was further derivatized at fourth position by reacting with different aromatic aldehydes to give 4-benzylidene-pyrazolidine-3,5-diones, followed by the 4-chloro-butyl and 4-nitrooxy-butyl substitution at nitrogen atom. The synthesized products were characterized by physicochemical and analytical means. Few of the synthesized derivatives showed excellent antibacterial and antifungal...
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Posted by admin on Jan 1, 2013 in |
Medicinal plants are extensively used to cure various infectious diseases in human. Our present study was undertaken to investigate antibacterial activity in leaf, stem and root extracts of Acalypha indica against the human pathogens such as Staphylococcus sp, E. coli, Salmonella sp, Klebsiella pneumonia and Pseudomonas. The shade dried leaves, stem and root powder was used to prepare extracts by using and acetone, methanol and ethanol by soxhlet method. The antibacterial activity was studied by using agar well diffusion method with different concentrations of extracts (25, 50, 75 & 100µl). The result showed that ethanol leaf extract is effective against tested pathogen. Highest inhibition of zone was recorded in E. coli ( 22 cm). Phytochemical analysis of Acalypha indica was done. In the present study, the antimicrobial factors of A. indica were found to have Flavonoids, Triterpenoids, Phenolic compounds and proteins in leaf and its molecular weight was found to be 19kDa. Recognition of the molecular factor responsible for bactericidal activity in herbs will pave the way to commercialize...
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Posted by admin on Jan 1, 2013 in |
Mucilaginous exudates from Aloe leaf containing polysaccharides, of which the major proportion has been reported to be composed of acetylated mannose molecules such as Acemannan and other high molecular weight polysaccharides. These polysaccharides, have been reported to elevate the Granulocyte Macrophage Colony Stimulating Factor (GMCSF) ultimately leading to the infiltration of macrophages at respective sites. This immunological property has been exploited to test the efficacy of dried aloe mucilaginous extract containing these high molecular weight polysaccharides for anti-fertility activity. The polysaccharides were extracted by ethanol precipitation method. The suspension of extract in aqueous medium was prepared under aseptic environment to ensure the desired sterility. Characterization of extract was done by spectrophotometry and IR spectroscopy. The results suggest the presence of biologically active polysaccharides. The preliminary finding of the experiment confirms the anti-fertility activity in rats. However, a mild edema was observed in the uterine horns of the test group animals which subsequently reduced in severity upon reducing the dose. The cause of the oedema could be attributed to the...
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Posted by admin on Jan 1, 2013 in |
Patients want and are seeking more information about drug and nondrug treatment options. While a great deal of patient information about medications, treatments, and diseases exists, much of it contains conflicting, inaccurate, poorly written, or non–evidence-based information. The objective of the study was thus, to assess what patients want to know about their medications at Gondar University Hospital. The study was conducted in Gondar University Hospital over 1 month period from March 1- 30, 2012. Data was collected using convenience sampling technique from 384 respondents using structured questionnaire which consists of 40 items. All data collected were then analyzed using the Statistical Package for Social Sciences (SPSS), v19 software. In the study 238 (68%) male and 146(32%) female patients were included. From the total questions forwarded for the total population 165(43%) responded drug information as very relevant, 156(40.6%) responded drug information as relevant, 40(10.4%) responded drug information as somewhat relevant and 23(6%) answered drug information as not relevant. Concerning drug information source the result showed that 49%, 49% and...
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