Posted by admin on Nov 1, 2012 in |
In recent years, there is a tremendous increase of drug resistant pathogens, leading to the design and development of newer antitubercular agents. A series of 2-(substituted-phenyl)-1,3-benzoxazin-4-ones and 3-amino-2-(substituted-phenyl)quinazolin-4(3H)-ones were synthesized by the reaction of substituted benzoyl chloride with anthranilic acid and 2- (substituted phenyl)-1,3-benzoxazin-4-one with hydrazine hydrate in absolute alcohol respectively. The title compounds 2-substituted phenyl-3-(thiophen-2-ylmethyleneamino) quinazolin-4(3H)-ones and 2-(substituted phenyl)-3-(1-(furan-2-yl)ethylideneamino) quinazolin-4(3H)-ones were obtained by reacting 3-amino-2-(substituted phenyl) quinazolin-4(3H)-one with thiophene-2-carboxaldehyde and 2-acetyl furan respectively. The title compounds have been characterized by UV, IR, 1H-NMR and Mass spectra. The synthesized compounds have been evaluated for their antitubercular activity. Few of the compounds exhibited significant antitubercular while other compounds showed moderate...
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Posted by admin on Nov 1, 2012 in |
Objectives: To assess the effect of unripe dried banana powder in experimentally induced gastric ulcers and effect on gastric acid secretion. To evaluate the antiulcerogenic effect of plantain banana of Gujarat as a part of evaluation of impact of biological variables on this activity. Results: Orally administered banana powder in the dose of 2gm/kg caused a statistically significant decrease in aspirin with pyloric ligation induced ulcers in rats without significantly decrease in secretary activity.Materials and methods: Total of 24 albino rats of either sex weighing between 150-250 gm were randomly divided into 4 groups. Each group has 6 no. of rats. The first group received placebo (distilled water), the second, third & forth group received 0.5gm/kg, 1gm/kg and 2mg/kg of banana powder respectively. Banana powder was given as suspension at fixed time (3 times in a day) for two days and animals were kept for fasting for another 48hrs. On 5th day, the animals were sacrificed after 7 hrs and stomach were removed for examination and gastric juice samples...
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Posted by admin on Nov 1, 2012 in |
In our study, the sample (cheese) was selected for isolation and identification of Lactobacillus species as local probiotic isolate. The strain was subjected to microscopic and macroscopic investigations for probiotic selection. The world health organization criteria (WHO) were applied to all Lactobacillus species against E. coli, P. areoginosa, S. aerus, Chromobacterium, Serratia and A. flavus, antibiotic sensitivity test, acid and bile tolerance test, heamolytic activity. Antimicrobial compound called bacteriocin was partially purified. The Lactobacillus species was identified by 16S rRNA gene sequencing and specific catalase gene was also amplified. Data showed that Lactobacillus plantarum has a high inhibitory activity, tolerant to bile and acid, highly resistant to many antibiotics. Antimicrobial peptide was partially purified, characterized and bacteriocin produced by L. plantarum remained constant activity after heating at 121oC for 10 min. L. plantarum may be an alternative and promising way for eradicating many diseases. L. plantarum produces antimicrobial metabolites can give reasonable assurance of the control of pathogenic microorganisms. Increase the number of food-poisoning patients, the inhibition of the...
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Posted by admin on Nov 1, 2012 in |
Postcoital vaginal rupture or tear is a well-known entity to the gynecologist. We highlight case of a marital post coital rectovaginal tear with fecal incontinence and complete avulsion of anal sphincters. Patient underwent layered repair and sphincter reconstruction after bowel preparation. Postoperatively she had a satisfactory continence over flatus and...
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Posted by admin on Nov 1, 2012 in |
Cancer – one of the most pervasive diseases, thus far mostly in affluent countries – is fast raising its ugly head in the developing world. This is a survey work on cancer due to recent increasing of the number of cancer patients in Bangladesh. This study was carried out in Ahsania Mission Cancer Hospital, Dhaka Bangladesh as this is the biggest missionary hospital in this country, From 13 February 2011 to April 13, 2011. A total of 352 patients were enrolled in the study. Of them 160 were male & 192 were female patients. The female patient were greater in number than male patient. Among the male there were 38.75% farmer, 33.12% day labor great in number. Among the female 92.70 % were housewives. According to the age distribution of patients the study was carried out in the range of (0-90) years. Most number of patients (30.39%) was seen in the age of 41-50.Among the cancer patient addiction history is alarming to chewing tobacco (32.64%), smoking (35.77%) and Tea...
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