Posted by admin on Oct 1, 2012 in |
FDTs are designed to disintegrate rapidly on contact with saliva and enables oral administration without water or chewing, these formulations offer increased convenience and ease of administration with the potential to improve patient compliance, particularly in certain populations, where swallowing of conventional solid oral dosage forms presents difficulties. In the present study, the effect of a natural superdisintegrant Fenugreek and synthetic superdisintegrants sodium starch glycolate (SSG) was compared in the formulations of fast dissolving tablets (FDT). FDTs of Diclofenac (model drug) were prepared by direct compression method. These tablets were evaluated for weight variation, hardness, thickness, disintegration time, water absorption ratio, friability and dissolution. Swelling index was also investigated with an aim to compare the swelling property of Fenugreek with Sodium starch glycolate (SSG). Fenugreek showed higher swelling index than SSG. Hence, the present study revealed that this natural superdisintegrants showed better disintegrating property than the most widely used synthetic superdisintegrants like...
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Posted by admin on Oct 1, 2012 in |
The objective of this study was to conduct a survey and determine the barriers to implement performance-based management in pharmacies in Trinidad. PBM is defined as “a systematic approach to performance improvement through an on-going process of establishing strategic performance objectives, measuring performance, collecting, analyzing, reviewing, and reporting performance data, and using that data to drive performance improvement”(Performance Management Handbook). A questionnaire was conducted, with respect to the presence or absence of barriers to implementation of performance-based management at pharmacies along the East-West corridor of Trinidad. A twenty-two (22) question survey was administered to sixteen (16) pharmacies to be assessed. This region was chosen because of its close proximity and convenience. Fourteen (14) of the twenty-two (22) questions were based on a Likert-type scale, so that respondents were able to specify their level of agreement or disagreement of applicability on a symmetric “strongly agree – strongly disagree” scale for a series of statements based on the barriers of PBM implementation. Pharmacies were selected in a non-randomized manner. The SPSS...
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Posted by admin on Oct 1, 2012 in |
Pluchea lanceolata has been used in massage oil as well as in traditional ayurveda as a potent pain reliever. The traditional Method of obtaining oil is simply based on taking water as the medium for extraction. The water extract obtained is then boiled with oil, till the water is completely evaporated. Here, our aim is to replace water by different organic solvents and obtain oil which has much better efficacy than the traditionally extracted oil. The idea here is to obtain more efficacious oil than the marketed sample which is majorly extracted using water as solvent. Here, the different organic solvents used are methanol, ethanol, petroleum ether and chloroform. The oil obtained was checked for its anti-inflammatory activity with the carrageenan induced rat paw edema. The prepared oil was compared with the marketed sample of mahanarayan oil. The ethanolic extract has showed to be having high extract yield in...
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Posted by admin on Oct 1, 2012 in |
Two simple, economical, precise, and accurate methods are described for the simultaneous determination of Paracetamol and Diclofenac in combined tablet dosage form. The first method is first- order derivative zero crossing method. The first order derivative absorption at 275.6 nm (zero cross point of Diclofenac) was used for Paracetamol and 242.69 nm (zero cross point of Paracetamol) for Diclofenac. The second one is simultaneous equation method in application to dissolution study. Simultaneous equation method was successfully applied to carry out dissolution study of commercial tablet formulation by using USP type II dissolution test apparatus. The solvent used is pH 6.8 phosphate buffer. Linearity range was 2-10µg/ml and 5-25 µg/ml for Paracetamol and Diclofenac respectively. The methods were validated with respect to linearity, precision and...
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Posted by admin on Oct 1, 2012 in |
Symphonia globulifera L.f. (Anani) is an arboreal species, which occurs in the Amazon with antimalarial and antimicrobial properties, especially in the treatment of skin inflammations. It is also used as a general tonic and laxative for pregnant women and its sap/latex is used against rheumatism and tumors. The utilization of natural products from plant origin implies in pharmacobotanical quality control, which consist of the technical specifications of the species. Anatomical description of the leaves and petioles of Symphonia globulifera L. f. were performed. Epidermal cells on both sides of the leaves were observed; they are heterodimensional and polygonal. The stomata are anomocytic and were found only on the abaxial surface. The petiole is plan-convex coated with quadrangular cells and thick cutinization. The results are relevant to the anatomical characterization of the species since data on leaf anatomy of S. globulifera are...
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