Posted by admin on Dec 1, 2012 in |
A novel, safe and sensitive method of spectrophotometric estimation in UV-region has been developed for the assay of paracetamol in its tablet formulation. The method have been developed and validated for the assay of paracetamol using Methanol and water as diluents. Which does not shows any interference in spectrophotometric estimations. All the parameters of the analysis were chosen according to ICH [Q2 (R1)] guideline and validated statistically using RSD and %RSD along with neat chromate...
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Posted by admin on Dec 1, 2012 in |
Cyclodextrin complexes of etoricoxib (poorly water soluble COX-2 inhibitor) were prepared with the β-CD and HPβ-CD by different techniques (physical mixture, kneading and co-evaporation methods) at 1:1 and 1:2 molar ratios. Characterization of the complexes was done in solution by phase solubility analysis and in solid state using FTIR. The stoichiometry and stability constants of ECB-β-CD (1:1-200.4 M-1) and ECB-HPβ-CD (1:1-166.94 M-1) complexes were calculated by phase solubility method. Remarkable improvement in in-vitro drug release profiles in distilled water was observed with all complexes, especially with those prepared by kneading method than with physical and co-evaporation methods. HPβ-CD gave highest enhancement in the dissolution rate of ECB. Thus, it is concluded that stable and dissolution improved CD complexes can be prepared for etoricoxib with β-CD and...
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Posted by admin on Dec 1, 2012 in |
The aim of the present research work was to enhance the solubility of Glipizide by solid dispersion method and to formulate a mouth dissolving tablet. Drugs are more frequently taken by oral administration. The solubility of Glipizide enhanced with different ratios of CCS by the kneading method .In-vitro release profile of solid dispersion obtained in Ph 6.8 phosphate buffer indicate that 100% drug release found within 20 min. These solid dispersions were directly compressed into tablets using sodium starch glycolate, crosspovidone and pregelatinised starch in different concentrations as a superdisintegrants. The prepared tablets containing the solid dispersion of Glipizide had sufficient strength of 1.5-2 kg/cm2. The disintegrated in the oral cavity within 21 sec. contain crosspovidone (5%) as...
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Posted by admin on Dec 1, 2012 in |
Irrational use of medicines results in poor patient clinical outcomes, adverse drug reactions, economic burden and antimicrobial resistance. The objective of this study was to evaluate drug prescription patterns in private and public health sectors in Wolkite town, South West Ethiopia. The drug prescriptions were evaluated in 11 private and public health facilities, Wolkite town, South west Ethiopia. Total patient records of 600 were collected by systematic random sampling technique from patients attended the facilities from January 1 to December 31, 2011, retrospectively. One thousand two hundred twenty seven drugs were prescribed for 385 patient encounters making the average number of drugs per encounter 3.20 + 1.01 (private=3.33, public= 2.89). Three hundred and one (78.2%) patients in private and public health facilities were prescribed with at least one inappropriate drug. Inappropriate choice of drug 108 (28.0%), over prescription of drugs 89 (23.0%) and inappropriate duration of treatment 28 (7.2%) were the three most prevalent cause of inappropriate prescriptions in the health facilities. Much remains to be done to promote rational...
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Posted by admin on Dec 1, 2012 in |
Pyrimidine is a six membered cyclic compound containing 4 carbon and 2 nitrogen atoms and is pharmacologically inactive but its synthetic derivatives possess an important role in modern medicine. Pyrimidines and their derivatives are considered to be important for drugs and agricultural chemicals. Pyrimidine derivatives possess several interesting biological activities such as antimicrobial, antitumor and antihypertensive activities. Many pyrimidine derivatives are used for thyroid drugs and leukemia. The biological significance of the pyrimidine derivatives has promoted us to synthesize some new substituted dihydropyrimidines, and evaluate them for their anti-microbial activity. The titled compounds were identified and characterized by IR and 1HNMR...
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