Posted by admin on Oct 1, 2012 in |
Salbutamol is a potent anti-asthmatic agent, is a short-acting β2-adrenergic receptor agonist act. In the present study, an attempt has been made to prepare fast dissolving tablets of Salbutamol in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carmellose sodium, Pregelatinized starch by direct compression method. The pre-compression parameters of mixed blend were examined for angle of repose, bulk density, tapped density, Compressibility index and Hausner’s ratio. The tablets were evaluated for hardness, friability, weight variation, disintegration time, dissolution rate, content uniformity and drug content. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrate with enhanced dissolution can be made using selected superdisintegrants. Among all formulations, batch D4 was considered as best since it showed enhanced dissolution, which leads to improved bioavailability, improved effectiveness and hence better patient...
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Posted by admin on Oct 1, 2012 in |
In this study, α-naphthyl acetic acid and mannitol were used as elicitors to improve the productivity of useful metabolite, vasicine for archiving high concentration in Justicia adhatoda L. cell suspension cultures. When the cells were treated with 3mg 100 ml-1 suspension of α-naphthyl acetic acid, the vasicine concentration was increased by 1.65 mg ml-1 in 15 days culture compared to untreated cells. 0.32M 100ml-1 mannitol could also promote the synthesis of vasicine in the cell cultures. After 15 days of the cell culture, it was found that the vasicine concentration was 1.48 mg ml-1 more than the control cell...
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Posted by admin on Oct 1, 2012 in |
Goal of the present investigation was to formulate ocular inserts of dorzolamide hydrochloride and timolol maleate for the treatment of glaucoma. Ocular inserts of dorzolamide hydrochloride and timolol maleate were prepared using different polymers ethylcellulose, Eudragit RL 100, and Eudragit RS100 by solvent casting method with an objective to increasing the contact time, achieving controlled release, reducing in frequency of administration, and improving therapeutic efficacy. The drug-excipients interaction was studied by Fourier transform infrared spectroscopy (FTIR) studies. Prepared ocular inserts were evaluated for their physicochemical properties such as uniformity of thickness, weight uniformity, tensile strength, percentage elongation, drug content, moisture loss, moisture absorption. The in vitro diffusion of drug from the inserts was studied using the classical biochemical donor – receptor compartment model fabricated in the laboratory and the formulation that showed better release profile was subjected to in vivo studies on albino-rabbits. Ocular irritation study was performed using healthy albino rabbits and confirmed that there was no irritation in the rabbit eyes. All the inserts were found to...
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Posted by admin on Oct 1, 2012 in |
In the quest for novel PPARg agonists as putative drugs for the treatment of type 2 diabetes, a new series of 2-pyrazolin-5-one and pyrazolidine-3, 5-dione derivatives, were designed and synthesized, as analogues to the anti-diabetic thiazolidinedione agents (TZDs). Extensive molecular modeling studies for the designed molecules were performed; including their compare-fit studies on the generated and validated PPARg agonist’s hypothesis and their molecular docking on the binding sites of the 3D structure of the PPARg...
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Posted by admin on Oct 1, 2012 in |
The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent flow rate of 1.0 ml/min, and UV detection wavelength 263 nm. The developed method was statistically validated for linearity, precision, robustness, ruggedness and specificity. The method was linear over the range of 5-80 µg/ml for paracetamol and 3-48µg/ml for...
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