Posted by admin on Jan 1, 2013 in |
The performance of whole building depends on many factors: structure, coating, environment, climate, type of use, service etc. Fungi are essential for the survival of our global ecology but they may pose a significant threat to the health of occupants when they grow in our buildings. The most important factor that affect microbial growth on buildings materials are temperature, moisture and nutrients. The moisture conditions connected with temperature and exposure time are the most important factor for the development of biological problems and damage in buildings. In vitro studies were conducted on the effect of temperature, pH levels and moisture on the growth of Aspergillus flavus and Penicillium chrysogenum. Maximum growth was observed on pH level 6 and 7 against A. flavus and P. chrysogenum respectively after 12 days. The most suitable temperature for the growth of A. flavus and P. chrysogenum was observed on 25°C and 30°C respectively. The fungus showed maximum growth at 90% relative...
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Posted by admin on Jan 1, 2013 in |
A series of 1, 3, 4-oxadiazole derivatives were designed and out of which six compounds have been synthesized via four step synthetic scheme and evaluated for antibacterial activity using cup plate method. The compounds were previously characterized by IR, 1H-NMR spectral analysis. The compounds with hydroxyl and methoxy substituted phenyl rings showed higher activity than the chloro substituted derivatives and standard i.e vancomycin. The antibacterial study revealed that the most promising compounds are 3-(4-hydroxyphenyl)-1-(5-(2-hydroxyphenyl)-2-phenyl-1,3,4-oxadiazol-3(2H)-yl prop-2-en-1-one 6.4(a), 3-(4-methoxyphenyl)-1-(2,5-di phenyl-1,3,4-oxadiazol-3(2H)-yl)prop-2-en-1-one 6.4(b), 3-(4-hydroxy phenyl)-1-(2,5-diphenyl-1,3,4-oxadiazol-3(2H)-yl)prop-2-en-1- one 6.4(c), 3-(4-hydroxy phenyl)-1-(2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)-yl)prop-2-en-1-one 6.4(e), 1-(2-(4-hydroxyphenyl)-5-phenyl-1,3,4-oxadiazol-3(2H)-yl)-3-(4-methoxy phen yl)prop-2-en-1-one 6.4(f) against the tested bacteria (S. aureus, B. subtilis, P. aerugenosa, E. coli). This preliminary study revealed that these compounds may be used as potential leads for further...
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Posted by admin on Jan 1, 2013 in |
Cough is a natural reflex expulsive defense mechanism of the body, for clearing excess secretions, mucous, inhaled irritants, toxins or foreign substance in the respiratory tract.It is the most common symptom of respiratory disease. When cough becomes serious, opioids are effective, but they have side effects like sedation, constipation, some addiction liability and also compromise the respiratory function. Therefore, there is a need to have effective anti-tussive agent which do not have respiratory suppressant activity. The present study was carried out to evaluate anti-tussive activity of leaves of Caesalpinia bonducella in ammonium hydroxide induced coughmodel in...
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Posted by admin on Jan 1, 2013 in |
Tribulus terrestris L. (TT; Zygophyllaceae) is employed in the folk medicine against sexual impotence, oedemas, abdominal distention and cardiovascular diseases. Gastroprotective (i.e. antiulcer and anti-secretory) potential of methanolic extract of TT fruits was evaluated in pylorus-ligated rat model of Wistar rat. The methanolic extract of TT was tested orally at the doses of 150, 300 & 600 mg/kg, on gastric ulcerations experimentally induced by pylorus ligation. Preliminary phytochemical screening of the methanol extract of TT showed the presence of alkaloids, carbohydrates, cardiac glycosides, flavonoids, saponins, tannins and proteins. The methanolic extract at the doses of 300 & 600 mg/kg produced more significant inhibition when gastric ulcerations were induced by pylorus ligation respectively. The methanol extract of the fruits of Tribulus terrestris L. possess gastroprotective i.e. antiulcer and anti-secretory...
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Posted by admin on Jan 1, 2013 in |
The object of the study was to formulate and evaluate Aceclofenac orodispersible tablets (ODT) by wet granulation method using different super disintegrants in different concentrations. Orodispersible tablets produce rapid dissolution of drug and absorption thereby producing rapid onset of action. Five batches (AFD1, AFD2, AFD3, AFD4, AFD5) of Aceclofenac orodispersible tablets were prepared and characterized for hardness, friability, thickness, uniformity of weight, drug content, disintegration time, In-vitro dissolution studies. Formulation (AFD5) was found to be better formulation in terms of rapid disintegration and maximum percentage of drug release compared to other...
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