Posted by admin on Oct 1, 2012 in |
In developing countries, the majority of people living in rural areas almost exclusively use traditional medicines to treat all sorts of diseases including diarrhea. Many plants namely Andrographis paniculata, Acacia catechu, Acacia chandra, Terminalia chebula, Pterocarpus marsapium, Cassia auriculata etc. available in india are used in traditional folklore medicine for the treatment of diarrhea. Diarrhoea is a comman cause of illness resulting in high mortality in developing countries worldwide distribution of diarrhoea accounts for more than 5-8 millions deaths each year. It thus becomes important to identify and evaluate scientifically the antidiarrhoeal effects of leaves of Acorus calamus against castor oil induced dirrhoea. Methanolic Extract was studied for antidiarrhoeal potential using wistar rats and loperamide as a standard. Extracts were administered orally to test animals. Stools were collected upto 4 hrs in transparent plastic dishes of uniform weight. Urine was drained off by gravity every 15 mins. during the 4 hrs. diarrhoeal free period, acute diarrhoea and late diarrhoeal excretions were noted. Gastrointestinal motility test also performed. Methanolic extract...
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Posted by admin on Oct 1, 2012 in |
Stavudine an anti-retroviral drug is used for treating HIV now-a-days. The present approach aims to formulate an orally disintegrating tablet of stavudine for better patient compliance and bypassing the hepatic metabolism. In order to have an orally disintegrating tablet of stavudine, there is a need to mask the bitter taste. For the masking of bitter taste mannitol is used as taste masking agent. In the formulation of ODTs, a semi-synthetic super disintegrant sodium starch glycolate and a natural disintegrant, sodium alginate was used. Formulations F1, F2, F3, S1, S2 and S3 were evaluated for the required quality control tests.F3 and S3 were found to have a disintegration time of 7secs and 6secs, respectively. Upon observing the dissolution profiles and disintegration time of formulations, F3 and S3 showed good...
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Posted by admin on Oct 1, 2012 in |
The objective of the present study was to prepare a matrix tablet for colon targeting. Natural gaums (guar gum and xanthan gum) were used for the preparation of colon targeted drug delivery system. Different concentrations of guar gum and xanthan gum and their combinations were tried for the purpose. The prepared tablets were evaluated for in-process parameters as well as colon targeting characteristics. The colon targeting properties were evaluated by analysing the formulations for drug release in physiological pH medium of colon. All the formulations were found to be suitable in in-process quality control parameters. The guar gum and xanthan gum were used from 10% to 30% concentration in the formula. The third series of formulations contained guar gum and xanthan gum combinations in ratios of 10% and 20%, 20% and 10% and 15% and 15% respectively. The drug release was found to be 82% to 100% for guar gum formulations, 85% to 99% for xanthan gum formulations and 87% to 100% for the combination of xanthan gum and...
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Posted by admin on Oct 1, 2012 in |
A new, simple and rapid reversed-phase high-performance liquid chromatography (HPLC) method was developed and validated for the determination of some azoles drug (Ketoconazole, Isoconazole and Miconazole) in pharmaceutical dosage forms in Jordan market. The HPLC separation was achieved on a C18 BDS column (100 mm × 4.6 mm) using a mobile phase of acetonitrile and 0.05 M Ammonium Acetate buffer (70:30, v/v) that adjusted to pH 6 using phosphoric acid at a flow rate of 1 mL min−1 and using UV absorbance detection at 254 nm. The method was validated for specificity, linearity, precision, accuracy, robustness. The separation was completed within 11.77 minutes and the assay was linear over the concentration range of 50% to 150% (r2 = 0.9999), the percent recovery for test and reference formulation was...
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Posted by admin on Oct 1, 2012 in |
Background: Following the Alma-Ata Declaration of 1978, the World Health Organization (WHO) began the issuance of guidelines for developing standardized herbal preparations from Traditional Medicine (TM). Similarly in 1987, the International Organization for Standardization (ISO) launched the most anticipated industrial standard (ISO 9001) in world history. The seventh (7th) clause of ISO 9001’s eight clauses is devoted to “Product Realization”- a quality management system (QMS) procedure that includes: planning of product realization; appreciation of customer-related processes; design and development processes; purchasing; production and service provision; and control of measuring and monitoring equipment. Purpose: The article takes a hard look at the QMS processes involved in product realization and the critical stages of the WHO model of herbal drug development from TM, with a view to devising a framework that can be used to promote the production of quality herbal products, commencing from the stage of ethnobotanical survey, through the laboratory, to the clinic. Methodology: Both the WHO model of herbal drug development and the 7th clause of ISO 9001:2008...
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