Posted by admin on Sep 1, 2012 in |
A new specific, selective and inexpensive spectrofluorophotometric method has been developed for determination of Nelfinavir mesylate in bulk drug and its dosage form. Fluorescence spectrum of Nelfinavir mesylate in methanol showed excitation wavelength at 253 nm and emission wavelength at 508 nm. The calibration curve for Nelfinavir mesylate was found to be linear over the concentration range of 100-225 ng/mL with correlation coefficient of 0.988 for bulk drug. Limit of detection and limit of quantification were found to be 8.42 ng/mL and 28.09 ng/mL respectively. Method was validated as per ICH guidelines and found to be suitable for estimation of Nelfinavir from bulk drug and its pharmaceutical dosage...
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Posted by admin on Sep 1, 2012 in |
An in vitro study was conducted for screening antibacterial activities of seeds of Trigonella foenum-graecum (fenugreek)and rhizomes of Zingiber officinale (ginger), in their different forms viz. aqueous extracts, essential oils and powders against some common food borne pathogens. Bacterial strains involved in the study were Bacillus cereus (MTCC 430), Enterococcus feacalis (MTCC 439), Escherichia coli (MTCC 1687), Psuedomonas aeruginosa (MTCC 424) and Staphylococcus aureus (MTCC 5021). Results revealed that powdered forms of T. foenum-graecum and Z. officinale remained ineffective in arresting the growth of all the bacterial strains under investigation. During preliminary screening, aqueous extracts and essential oils of test spices did not exhibit any growth inhibitory zone towards any test bacteria. In broth dilution technique, essential oil of Z. officinale arrested all the bacterial strains under observation while essential oil of T. foenum-graecum and aqueous extracts of T. foenum-graecum and Z. officinale remained...
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Posted by admin on Sep 1, 2012 in |
Newer NSAIDs like Aceclofenac and Lornoxicam are being marketed by pharmaceutical industries with claims of better efficacy and safety than conventional NSAIDs like Diclofenac. So this study aims to comparatively assess the safety, efficacy and cost of Aceclofenac, Lornoxicam and Diclofenac in patients of musculoskeletal disorders. Patients presenting with musculoskeletal disorders were randomized into three treatment groups (50 in each). Comparative analgesic efficacy assessment between the three drugs were done by using visual analog scale (VAS) reading on Day-0 and then weekly till 3 weeks; adverse drug reaction (ADR) information were collected by spontaneous reporting from patients and by active surveillance and were recorded in a predesigned proforma. Relative cost was assessed by comparative unit cost price of individual drugs (of different pharmaceutical companies). It was observed that Lornoxicam, Aceclofenac and Diclofenac are equally effective as analgesic. Both Aceclofenac and Lornoxicam have similar ADR profile which is significantly less than that of Diclofenac. Though analgesic activity and safety profile of Aceclofenac is comparable to Lornoxicam, but Aceclofenac is cheaper...
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Posted by admin on Sep 1, 2012 in |
Aim: Present study was done to know the prevalence of the use of dietary supplements and ayurvedic drugs by patients taking allopathic drugs. Introduction: Allopathic drugs are likely to act with ayurvedic drugs and dietary supplements and concurrently used. This concept is usually not recognized by the patients and physicians. Sometimes this may prove dangerous. Present study was done to find out the prevalence of concurrent administration of these produce so that a message can be spread to reduce these habits in patients and physicians. Method: We did study among private practitioners of medicine, general surgery and gynaecology specialities. The patients were interviewed by our team members and requested to fill a proforma. After completion of study data were segregated and analyzed for various parameters. Results: Results showed that 25.6% patients attending physician, 39.9% attending surgeons and 41.4% attending gynaecologists were taking some or other preparations in various forms. Out of all patients only 18.2% patients knew that these preparations were also a form of drug. Only 9.1% of...
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Posted by admin on Sep 1, 2012 in |
The present study was planned to investigate the effect of ethanolic extract of Leucas Urticifolia on resutured incision, excision and burn wounds in Wistar rats. Resutured incision, excision and dead space wounds were inflicted under light ether anaesthesia aseptically. In incision wound model the control animals receive only distilled water and all test animals were treated with different doses of Lucas urticifolia ethanolic extract (100, 200 and 400 mg/kg), orally for a period of 10 days. On the day 11, wound breaking strength of the resutured incision wound was estimated. In excision and burn wound models the animals were treated topically daily with two different concentrations (5% and 10%w/w) of extracts and the rats of standard groups were treated with 5% povidone iodine ointment topically till the complete closure. The percentage wound contraction and epithelization period were studied from day of creating wound till complete closure of the wound. The ethanolic extract of L. urticifolia show significant wound healing activity against all wound models studies. High wound breaking strength,...
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