Postcoital vaginal rupture or tear is a well-known entity to the gynecologist. We highlight case of a marital post coital rectovaginal tear with fecal incontinence and complete avulsion of anal sphincters. Patient underwent layered repair and sphincter reconstruction after bowel preparation. Postoperatively she had a satisfactory continence over flatus and...
Read MoreCancer – one of the most pervasive diseases, thus far mostly in affluent countries – is fast raising its ugly head in the developing world. This is a survey work on cancer due to recent increasing of the number of cancer patients in Bangladesh. This study was carried out in Ahsania Mission Cancer Hospital, Dhaka Bangladesh as this is the biggest missionary hospital in this country, From 13 February 2011 to April 13, 2011. A total of 352 patients were enrolled in the study. Of them 160 were male & 192 were female patients. The female patient were greater in number than male patient. Among the male there were 38.75% farmer, 33.12% day labor great in number. Among the female 92.70 % were housewives. According to the age distribution of patients the study was carried out in the range of (0-90) years. Most number of patients (30.39%) was seen in the age of 41-50.Among the cancer patient addiction history is alarming to chewing tobacco (32.64%), smoking (35.77%) and Tea...
Read MoreSpectrophotometric method for degradation study of Tenofovir disoproxil fumarate was described. The ultra violet spectrum of both acidic and basic degraded product was found to substantial difference from pure drug. The extent of degradation can be calculated by comparing the decrease in absorbance at selective wavelength. The zero order UV spectrums of TDF showed maximum absorbance at 260nm and at 220nm. The solution in NaOH did not show any absorbance at 220 nm in zero order spectrums and showed decrease in absorbance at 260nm. So the decrease in absorbance at 260 nm was used as measure of extent of degradation in NaOH. In case of HCl degradation also decrease of absorbance is seen due to degradation but in comparison to NaOH degradation is lesser. Absorbance is seen at 260nm in zero order spectrums and there is no peak observed at 220nm. In case of HCl degradation also decrease of absorbance is seen due to degradation but in comparison to NaOH degradation is lesser. Absorbance is seen at 260nm in...
Read MoreQuantitative structure activity relationship (QSAR) studies ware performed on series of structurally similar heterocyclic sulfonamide with enzyme gamma secretase inhibitor activity. The compounds were divided into training and test set and generated different QSAR models using V-Life MDS 3.5 software multiple linear regression (MLR) method. Best QSAR models were selected on the basis of various statistical parameters like square correlation coefficient (r2), cross validated square correlation coefficient (q2), pred_r2, standard error of estimation (SE) and sequential Failure test (F). 2D QSAR study reveals that gamma secretase inhibitor activity is governed by physicochemical Alignment Independent (AI) descriptors and design new compounds, with more potent activity. The best models were found to be Model–I model-II and model-III. Model-I having 5 descriptors, r2 = 0.8582, q2 = 0.5701, Failure test = 22.9812 and predicted r2 = 0.7513. Model-II having 4 descriptors, r2 = 0.8170, q2 = 0.6780, Failure test = 18.9765 and predicted r2 = 0.6193. Model-III having 4 descriptors, r2 = 0.8248, q2 = 0.7006, Failure test = 20.0027 and predicted...
Read MoreThe aim of this research was to investigate cytotoxic effects of crude extracts of Caesalpinia pulcherrima (Family: Fabaceae). The flower of Caesalpinia pulcherrima was extracted with methanol and methanolic extract was fractionated into three fractions like n-Hexane, ethyl acetate and chloroform. The methanolic crude extracts were screened for cytotoxic properties using brine shrimp lethality bioassay. A reputed cytotoxic agent vincristine sulphate was used as a positive control. From the results of the brine shrimp lethality bioassay it can be well predicted that n-hexane, ethyl acetate, chloroform soluble fractions of Caesalpinia pulcherrima flower possess cytotoxic principles (LC50 1.940mg/mL, 2.704mg/mL and 8.359mg/mL respectively) comparison with positive control vincristine sulphate (LC50 0.563...
Read More
