Posted by admin on Aug 31, 2023 in |
Epilepsy is a common neurological disorder in clinical practice requiring newer targets for its efficient treatment. Recently, brain renin-angiotensin system has gained immense importance because of its involvement in seizure regulation. Hence, the present study was planned to evaluate whether angiotensin II AT1 receptor antagonists possess anticonvulsant activity in experimental animals. Forty- eight Swiss albino mice were divided into 8 groups: Control – distilled water (5ml/kg), Standard – ethosuximide 200mg/kg, T1- telmisartan 5mg/kg, T2- telmisartan 8mg/kg, V1- valsartan 10mg/kg, V2- valsartan 20mg/kg, E+T2- ethosuximide 200mg/kg+ telmisartan 8mg/kg, E+V2- ethosuximide 200mg/kg+ valsartan 20mg/kg. After 1 hour of administration of control, test and standard drugs intraperitonally, convulsions were induced by administering pentylenetetrazol (60mg/kg- s.c). The time of onset of myoclonic spasm and clonic convulsion were the parameters recorded. The results were analysed by one-way- ANOVA followed by Dunnett’s t test. Telmisartan 8mg/kg, valsartan 10mg/kg, valsartan 20mg/kg significantly increased the latency of onset of myoclonic spasm and clonic convulsion (p< 0.05) as compared to control. The combinations of (ethosuximide + telmisartan 8mg/kg)...
Read More
Posted by admin on Aug 31, 2023 in |
Gastric inflammation and ulceration are directly associated with accumulating reactive oxygen species, interleukins, TNF-α, and depletion of antioxidants. In addition to the frequent use of non-steroidal anti-inflammatory drugs, gastric lesions are also provoked by stress, alcohol consumption and Helicobacter pylori. Among other NSAIDs, Indomethacin has been very effective compound to generate a gastric ulcer in rats’ gastric tissues. Ulcer of stomach generated by using Indomethacin involves the production of reactive oxygen species and upregulation of the activity as well as expression of matrix-metalloproteinase (MMPs). Various laboratory studies reveal that compounds from natural origin modify various metabolic disorders by changing pathological and physiological process. It can be a preventive method for various diseases including gastric ulcers. This project aimed to discover the anti-ulcerative effect of methanolic crude leaves extract on gastric ulcers induced by Indomethacin and cold stress in rodent’s model. Crude Neem leaves extract significantly inhibited gastric cancer cells survival in the cell culture model, protection in Indomethacin and stress induced gastric...
Read More
Posted by admin on Aug 31, 2023 in |
Fatty acids produced by plants protect themselves from pathogens, such as multidrug-resistant bacteria. In the present work, crude extracts, and fatty acid fractions of four pteridophyte species from Assam, Northeast India, were evaluated for their antimicrobial properties, and the bioactive compounds were identified using GC-MS analysis. The crude extract of Pteris semipinnata (Ps), Lygodium microphyllum (Lm), Lycodium flexuosum (Lf), and Lycopodiella cernua (Lc) was found to possess antibacterial and antifungal activities. The lowest MIC and MBC values were 0.25 mg/ml and 0.5 mg/ml for the fatty acid fractions against most of the microbial test strains. The GCMS analysis revealed 21 compounds in Ps, 35 in Lm, 33 in Lc, and 52 in Lf fractions. The present work supports the use of fern species in traditional medicine and...
Read More
Posted by admin on Aug 31, 2023 in |
Topical medications are frequently used to treat skin conditions. Antibiotic-resistant bacteria have emerged. As a result, the man has looked to nature for healing. Traditional medicines work better because they are less likely to cause side effects and are more effective. The Cocculu shirsutus and Tridax procumbens leaves were authenticated, dried, and extracted. Phytochemical screening and physicochemical analysis of extracts were done. The antimicrobial studies and in-vitro anti-inflammatory activity of extracts were carried out. The polyherbal gel was formulated by varying the concentrations of the gelling agents. The formulation was evaluated for physical appearance, visual homogeneity, pH, viscosity, and accelerated stability studies. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The F4 formulation showed the best results. Six batches of polyherbal gel were formulated using different gelling agents and varying concentrations. The best results were shown by F4...
Read More
Posted by admin on Aug 31, 2023 in |
Urinary tract infection (UTI) is one of the most common infections affecting humans and is one of the leading causes of both community-acquired and nosocomial infections. The study’s objective was to assess the rate of de-escalation and the impact of de-escalation on cost and length of stay, antibiotics utilization pattern, and adverse effects of antibiotics in bacteremic UTI. A prospective observational study was conducted on 218 UTI patients in a tertiary care hospital in Trivandrum for 6 months. The results showed that the incidence of UTI is higher in females. The most common symptom was identified as fever, followed by dysuria. Escherichia Coli was the causative organism in most of cases. Inj. Cefoperazone and Sulbactum was the most frequently prescribed antibiotic. Gastric irritation was experienced by 1.8% of patients followed by exanthema in 0.5% patients. The rate of successful de-escalation was 26.9% while 73.1% failed de-escalation. A significant association (p-value < 0.001) was found between de-escalation failure and length of stay. According to our study, the absence of de-escalation...
Read More
