Posted by admin on Aug 1, 2012 in |
The scientific basis of medicinal plants often claimed that the valuable ethnobotanical medicinal-related information was true. Hence, researchers always develop deep interest in finding natural resources like medicinal plants to combat infectious diseases instead of using modern pharmaceutical drugs that can lead to vast antibiotic resistance issues. In this present study, various leaf extracts of Persicaria chinensis (L.) H. Grosswere investigated for their antibacterial and antifungal activities against various Gram-positive and Gram-negative bacteria and fungi by disc diffusion method. The aqueous, chloroform, methanol, and petroleum ether extracts of P. chinensis leaves were prepared by cold maceration technique and preliminary phyto-constituent investigation was carried out on the extracts. The antibacterial and antifungal activities were assessed by measuring the diameter of the zone of inhibition, and the results were compared with standard antibiotics, amoxicillin and fluconazole respectively. All leaf extracts possessed antibacterial and antifungal activity against the selected pathogenic bacteria and fungi. Nevertheless, methanol and aqueous extracts and reference drugs (amoxicillin and fluconazole) showed comparable efficacy in inhibiting certain microbial growths....
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Posted by admin on Aug 1, 2012 in |
This paper deals with the significance and importance of medicinal plants.New flavone glycoside A, m.p. 222-224oC, m.f. C34H42O20, [M+] 770 (FABMS) has been isolated from the stems of Sesbania aculeata Pers. along with three known compounds Kaempferol 3-O-a-L-rhamnopyranosyl-(1®2)-b-D-glucopyranoside, (B) and Mearnsetin-3-O-a-L-rhamnopyranoside (C) Gehuain(isoflavone) (D). The compound A was characterized as 5, 7, 8-trihydroxy-6, 4’-dimethoxy flavone-7-O-a-L-rhamnopyranosyl-1®4)-O-b-D-xylopyranosyl-(1®4)-galactopyranoside by various chemical degradations and spectral analysis. Compound was subjected to antioxidant, antibacterial activity. Compound A showed potent antioxidant activity, of which the methanol and chloroform fraction demonstrated the strongest. Antioxidant activity with the IC50 value of 52.40 μg/ml and 60.15 μg/ml,...
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Posted by admin on Aug 1, 2012 in |
Methanolic extracts of two Indian medicinal plants Juniperus communis and Solanum xanthocarpum, were examined for their antimicrobial potential against selected bacteria and fungi. The purpose of screening is to justify and authenticate the use of Indian medicinal plants in ethno medicinal or folklore as traditional treasure to cure various ailments. In present investigations attempts were made to screen the Indian medicinal plants as antimicrobial agent. The extracts were tested against selected test bacteria and fungi through disc diffusion assay where Tetracycline and Mycostatin were used as standard. Indian medicinal plants have a traditional background that they have potentials to use as antimicrobial agents. The results showed that alcoholic extract possess excellent antimicrobial activity against selected test bacteria and fungi. The present results therefore offer a scientific basis for traditional use of the various extracts of Juniperus communis and Solanum...
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Posted by admin on Aug 1, 2012 in |
The compound drug Jawarish-e-Bisbasa is a polyherbal Unani formulation. It is used in the ailments of general weakness of the stomach, flatulence in the stomach, indigestion, blind piles and nausea etc. Therefore the scientific validation for development of SOP, pharmacopoeial standards, TLC studies and safety parameter is very much essential to provide the quality medicine to the needy mass. The drug was prepared in different batches at laboratory scale using authenticated nine raw drugs. The present study was aimed to develop the SOP’s for the preparation of drug and to evaluate its pharmacopoeial parameters, estimation of heavy metals, microbial load, aflatoxins and pesticide residues. The obtained physicochemical data will help in laying down SOP’s and pharmacopoeial standards for this drug. Thin Layer Chromatographic studies of the drug will provide the finger prints which will help in quality control and detection of adulteration. The result of quality control parameters such as microbial load, aflatoxins, heavy metals and pesticide residue shows that the drug is free from toxic...
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Posted by admin on Aug 1, 2012 in |
The present study involves preparation of floating microspheres of Ranitidine Hydrochloride with Sodium alginate, Guargum and Xanthan using ionic gelation method. Floating microspheres were aimed to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavailability. The formulations were evaluated for FTIR, drug loading, % entrapment, particle size, SEM, buoyancy, dissolution study and the drug release kinetics. The enhanced floatability of the formulation and its retention in GIT may attribute for the increased bioavailability and decrease in frequency of administration. Comparison of three polymers revealed HPMC to be a suitable candidate for sustained...
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