Posted by admin on Oct 1, 2012 in |
In the quest for novel PPARg agonists as putative drugs for the treatment of type 2 diabetes, a new series of 2-pyrazolin-5-one and pyrazolidine-3, 5-dione derivatives, were designed and synthesized, as analogues to the anti-diabetic thiazolidinedione agents (TZDs). Extensive molecular modeling studies for the designed molecules were performed; including their compare-fit studies on the generated and validated PPARg agonist’s hypothesis and their molecular docking on the binding sites of the 3D structure of the PPARg...
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Posted by admin on Oct 1, 2012 in |
The study describes a validated reverse-phase HPLC method for the simultaneous estimation of paracetamol and naproxen in bulk and in tablet formulation. The proposed RP-HPLC method utilizes Eclipse XDB C18 column (150 ×4.6 mm i.d., 5 µm), optimum mobile phase consisted of gradient run of initial ratio of water (pH-2.5 adjusted with orthophosphoric acid): acetonitrile (87:13) with the effluent flow rate of 1.0 ml/min, and UV detection wavelength 263 nm. The developed method was statistically validated for linearity, precision, robustness, ruggedness and specificity. The method was linear over the range of 5-80 µg/ml for paracetamol and 3-48µg/ml for...
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Posted by admin on Oct 1, 2012 in |
Pregnancy causes large physiologic changes in most body systems and these changes may lead to ease or harden examining some events. The purpose of this study is to define the rate of risk in pregnant women and the results in mother and fetus and also to define the risk rate of pregnancy in pregnant women and its effect on parameters after birth in patients of Educational and Medical center of Gorgan, Dezyani. This case – control study was performed in Educational and Medical Center Dezyany, of Golestan University of Medical Sciences in 1390. In this study, 1266 pregnant women were enrolled of which 804 cases (63.5%) according to the criteria for scoring in the questionnaire with a score greater than or equal to 7 were considered as high risk pregnancies (case group), 462 patients (36.5%) were considered as low-risk pregnancies (control group). Parameters after the birth and pregnancy results such as delivery type, infant difficulties, mother health after labor were compared and analyzed by T-test and ANOVA in both...
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Posted by admin on Oct 1, 2012 in |
A complete documentation of the ethno-biological information presently existing among the diverse communities is needed at an earliest so as to restore the traditional medicinal knowledge. Research to find out scientific evidence for claims by tribal healers on Indian herbs has been intensified as being evidenced from many cited literatures. Once these local ethno medical preparations are scientifically evaluated and disseminated properly, people will be better informed regarding efficacious drug treatment and improved health status. Hence, the plant, Mimosa pudica Linn. was selected for the present study based on its medicinal use in the locality. Successive solvent extraction of the root powder of M. pudica was carried out as per the standard procedure using various solvents like, petroleum ether (40o-60oC), ethyl acetate and methanol. Preliminary phytochemical analysis, isolation of metabolites and antimicrobial activities of the extracts as well as the first time reported isolates were carried out. Preliminary phytochemical studies of vaious solvent extracts revealed presence of many biologically important secondary metabolites, such as, alkaloids, steroids, phenolic compounds, tannins,...
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Posted by admin on Oct 1, 2012 in |
Aim: To assess the effect of vanadium compounds on glycemic control in diabetic rats. Methods: Eligible studies were identified by searching two databases; one search engine was also used for search of articles from different data bases using standardized terms and Boolean logic. Statistical analysis was performed with Meta Analyst software. Results: 56 relevant studies were found but only 8 studies met the inclusion criteria for this meta-analysis. Meta-analysis was done for blood glucose level from a pooled sample of 84 vanadium treated and 80 control diabetic rats. The analysis generated a combined standardized mean difference (Std. mean difference) of -5.21 and p< 0.00001 for blood glucose level. Additionally, all the included studies lay in favor of vanadium treatment. The meta-analysis for average weight and plasma insulin level did not show significant variation between vanadium treated and control diabetic rats. Conclusion: This meta-analysis reaffirmed that, vanadium compounds are able to reduce significantly blood glucose level and other base line measures like food intake and fluid intake without affecting plasma...
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