Posted by admin on Jun 30, 2023 in |
A series of flavones derivatives 11(a-j) have been synthesized and evaluated for their in-vitro antibacterial and antifungal activities. The antibacterial screening data showed that compounds with 4-methoxyphenyl (11c), 4-fluorophenyl (11d), and 2, 5-fluorophenyl (11h) substituent’s on tetrazole ring, showed the maximum activity against the organisms used. The antifungal screening revealed that a compound with 4-nitropheny (11g) on tetrazole ring exhibited the highest activity against A. niger and a compound with 4-methoxyphenyl (11c) group exhibited good activity against C....
Read More
Posted by admin on Jun 30, 2023 in |
Introduction: Herbs, which have been used to cure numerous ailments since ancient times, are important in building the foundation of modern medications. They are relatively safe to use, easily available, and also affordable. The present study aimed to investigate dry powder suspension formulated with Linum usitatissimum seeds extract, Cucurbita pepo seeds extract, Sesamum indicum seeds extract and Helianthus annuus seeds extract. Method and Material: The Soxhlet apparatus prepared Plant extracts using ethanol as a solvent. Various batches were prepared using the dried seed extract of individual herbs and the excipients. Further evaluation studies were carried out for all the batches to finalize the optimized batch showing good flow properties and drug release profile. Results: The optimized formulations showed acceptable evaluation results, including pH, angle of repose, carr’s index, sedimentation volume, redispersibility, viscosity, and drug release. Conclusion: The formulated dry powder suspension formulations showed good evaluation results and were within...
Read More
Posted by admin on Jun 30, 2023 in |
Herbs, which have been used to cure numerous ailments since ancient times, play an important role in building the foundation of modern medications. The present study aimed to investigate the antioxidant potential of nutraceutical dry powder suspension formulated with Moringa oleifera leaves and Celastrus paniculatus seeds extract against DPPH (2,2-diphenyl-1-picryl-hydrazine-hydrate). Plant extracts are prepared using ethanol as a solvent in the Soxhlet apparatus and extracts are evaluated for antioxidant activity using ascorbic acid as standard and best % inhibition of free radicals the dose is selected for formulation. Further evaluation studies are carried out for all the batches to finalize the optimized batch showing good flow properties and drug release profile. Both plant extracts showed good % Radical scavenging activity (%RSA) compared to ascorbic acid’s scavenging activity. The optimized formulation showed acceptable evaluation results, including pH, angle of repose, carr’s index, hausner ratio, sedimentation volume, redispersibility, viscosity and drug release. The formulated dry powder suspension formulation showed good antioxidant activity. Thus, the present investigation revealed that the developed nutraceutical...
Read More
Posted by admin on Jun 30, 2023 in |
Hordeum vulgare (Barley) grass is the best functional food for providing nutrition and eliminating toxins from human cells; however, its functional ingredients have also played an important role in health benefits. Flavonoids, saponarin, lutonarin, K, Ca, Se, dietary fiber, polysaccharide, alkaloid, glycoside, tannin, metallothionein and polyphenols are all found in barley grass. Microscopical studies showed that stomata, epidermal cells and trichomes were conducted as part of a pharmacognostic investigation of the grass of H. vulgare. The qualitative assays were done to predict the presence of phenols, tannin and flavonoid content. The Minimum inhibitory concentration (MIC) method was used to screen H. vulgare leaf extract for antimicrobial potential against S. typhi, S. aureus, B. subtilis and E. coli and chloramphenicol was used as a standard. Amongst all the extracts, the chloroform extract of H. vulgare was found to be more effective as its MIC value is almost equal to the standard antibiotic...
Read More
Posted by admin on Jun 30, 2023 in |
Antibiotic yield has been raised by numerous pharmaceutical firms in response to the rising population, the COVID-19 outbreak, and the introduction of several new diseases. Several heavy metals are used in the antibiotics’ formulation. The release of antibiotics and heavy metal ions has wreaked havoc on the ecosystem. The issue with heavy metals is that the bulk of them last a long time in the environment and are a leading cause of different types of cancer and other human diseases. On the other hand, experts worldwide are concerned about the presence of antibiotics in the environment, particularly in wastewater, because it leads to the emergence of antibiotic-resistant microorganisms (superbugs) that can cause widespread damage. Bioremediation is a viable approach for treating pharmaceutical industry wastewater with antibiotics and heavy metal ions. Copper, cadmium, nickel, zinc, lead and iron are common heavy metal ions found in wastewater from antibiotic-producing pharmaceutical firms. Along with it, antibiotics like chlortetracycline, oxytetracycline, cefalexin, Sulfamethoxazole, norfloxacin and ciprofloxacin are frequently found in the effluent of pharmaceutical...
Read More
