Posted by admin on Sep 1, 2012 in |
Aim: Present study was done to know the prevalence of the use of dietary supplements and ayurvedic drugs by patients taking allopathic drugs. Introduction: Allopathic drugs are likely to act with ayurvedic drugs and dietary supplements and concurrently used. This concept is usually not recognized by the patients and physicians. Sometimes this may prove dangerous. Present study was done to find out the prevalence of concurrent administration of these produce so that a message can be spread to reduce these habits in patients and physicians. Method: We did study among private practitioners of medicine, general surgery and gynaecology specialities. The patients were interviewed by our team members and requested to fill a proforma. After completion of study data were segregated and analyzed for various parameters. Results: Results showed that 25.6% patients attending physician, 39.9% attending surgeons and 41.4% attending gynaecologists were taking some or other preparations in various forms. Out of all patients only 18.2% patients knew that these preparations were also a form of drug. Only 9.1% of...
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Posted by admin on Sep 1, 2012 in |
The present study was planned to investigate the effect of ethanolic extract of Leucas Urticifolia on resutured incision, excision and burn wounds in Wistar rats. Resutured incision, excision and dead space wounds were inflicted under light ether anaesthesia aseptically. In incision wound model the control animals receive only distilled water and all test animals were treated with different doses of Lucas urticifolia ethanolic extract (100, 200 and 400 mg/kg), orally for a period of 10 days. On the day 11, wound breaking strength of the resutured incision wound was estimated. In excision and burn wound models the animals were treated topically daily with two different concentrations (5% and 10%w/w) of extracts and the rats of standard groups were treated with 5% povidone iodine ointment topically till the complete closure. The percentage wound contraction and epithelization period were studied from day of creating wound till complete closure of the wound. The ethanolic extract of L. urticifolia show significant wound healing activity against all wound models studies. High wound breaking strength,...
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Posted by admin on Sep 1, 2012 in |
This study was to evaluate the antioxidant and antibacterial efficacy of herbal crude extract of Murraya koenigii againsthuman Cariogenic pathogens. In this study Methanolic extract of Murraya koenigii were studied for phytochemical composition and GC-MS for active compound. Antioxidant potential assay by 1,1-Diphenyl- 2-picrylhydrazyl (DPPH), 2, 2’-azinobis-3 ethylbenzothiazoline-6-sulfonic acid (ABTS) and ferric reducing antioxidant power (FRAP) assays. Further extracts were studied for antibacterial activity. Methanolic extract of Murraya koenigii revealed the presence of terpenoids, alkaloids, tannins, steroids, and saponins. Reducing ability of extracts was in the range (in μm Fe(II)/g) of 3176.98±63.87 were closed to quercetin 3208.27 ± 31.29. A significant inhibitory effect of extract (IC50 = 0.019 ± 0.69 mg/ml) on ABTS free radicals was detected. The antioxidant activity of the extract (96%) DPPH radicals were comparable with that of ascorbic acid (98.8%) and BHT (97.5%). Antibacterial effect of 50% and 10% methanolic extracts was detected on Cariogenic pathogens as compared with standard drug Amoxicillin. GC-MS results revealed the presence of hexadecanoic acid, linoleic acid, oleic acid, propanoic...
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Posted by admin on Sep 1, 2012 in |
Ropinirole hydrochloride is indicated in Parkinson’s disease and Restless leg syndrome. In advanced Parkinson’s disease the usual dose of Ropinirole hydrochloride is 0.25 to 5 mg three to four times a day. Hence, an attempt was made to develop a once-a-day controlled release Osmotic drug delivery system. This may offer significant patient benefits by providing enhanced efficacy and reduced side effects and may also reduce the number of daily doses compared to conventional therapies. An oral push-pull system that can deliver Ropinirole hydrochloride for extended period of time has been developed and characterized. A bilayer osmotic drug delivery system was developed using drilling technique. The push layer swells releasing the drug at a controlled rate. An optimized system was selected to study the effect of pH of dissolution medium and the effect of agitation intensity. The drug release was found to follow zero order kinetics. The developed push-pull osmotic system showed the desired once-a-day release...
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Posted by admin on Sep 1, 2012 in |
Background: Noise has been recognized as one of the risk factors for cardiovascular diseases. Garlic is one of the oldest medications used in human culture. Garlic is used in herbal medicine for thousands of years and also as one of the main food ingredient. The present study was aimed to investigate the cardioprotective effect of garlic after noise exposure in Wistar albino rats. Methods: Animals were exposed to 1 day, 15 days and 30 days of noise stress exposure. The myocardial activity was evaluated by estimating the heart mitochondrial enzymes like malate dehydrogenase, isocitrate dehydrogenase, alpha ketoglutarate dehydrogenase, NADH dehydrogenase and cytochrome C oxidase. Garlic was administered to the animals at the dosage of 125 mg/kg b.w.) Conclusion: The result indicated that noise exposure affects the mitochondrial performance in the myocardium and that long-term consumption of garlic is beneficial. As garlic is already under human consumption, dietary supplementation of garlic for prolonged period may be beneficial as one could not avoid noise in the modern way of living. Results: Exposure...
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