Posted by admin on Oct 1, 2012 in |
Ground water is the most preferred water source in current scenario. Once believed to be safe from pollution as it is available many band below the surface, is now provided to be prone to pollution by research investigators. Various causes associated for the contamination of ground water. The major cause of the contamination of ground water may be due to improper disposal of industrial waste. The effort was made to assess the quality of ground water and thrash out the portability of ground water by physico-chemical temperament. Present study was carried out to assess the ground water quality of Singrauli district an energy hub station of Madhya Pradesh state of India Study was conduct in year 2012 by selecting 13 different spots, covered all the four directions of Singrauli. Ground water samples were taken from different sources such as bore well, well water, municipal supplier water etc. Investigations of Physico-chemical characteristics of groundwater quality based on Physico-chemical parameters have been taken up to evaluate its suitability for different objects....
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Posted by admin on Oct 1, 2012 in |
Extracts of hawthorn (Crateagus sp.) have been indicated in the treatment of cardiovascular diseases, however, tablets produced from dry extract due to a multiple of factors such as inconsistent botanical ingredients, moisture content and hygroscopicity turn to be hard with prolong disintegration. Dissolution test is increasingly being employed for the assessment of solid herbal medicinal dosage form due to its ability to predict the bioavailability of active therapeutic agent from herbal products. The aim of this study was to formulate coated tablets containing dry extracts of hawthorn leafs and flowers and to develop and validate a reverse phase high performance liquid chromatography (RP-HPLC) method for assessing in vitro dissolution profile of hawthorn tablet. Comparative extraction procedure studies showed that percolating the plant material with ethanol and extracting with ethyl acetate produce extract with the highest amount of total flavonoids calculated either as rutin or hyperoside and the highest hyperoside content. Assessment of two disintegrating agents; Sodium starch glycolate (SSG) and cross-linked polyvinyl pyrrolidone (PVPP) showed that PVPP was a...
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Posted by admin on Oct 1, 2012 in |
The objective of the present study was to develop and evaluate an oral pulsatile drug delivery system to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined log time of 5 hrs (+ 0.25 hrs). The basic design of the pulse in cap formulation of metoprolol provides time controlled release to treat the nocturnal symptoms of hypertension and angina pectoris. The pulsincap formulation of Metoprolol provides time controlled release to treat the nocturnal symptoms of hypertension and angina pectoris. If the formulation is administered in the night at 10.00 pm symptoms that are experienced in early morning hours could be avoided. In the present study, polymer such as Guargum selected for colon targeting of Metoprolol succinate. Metoprolol succinate granules were prepared using these polymers to prolong and target to the colon. Granules were prepared by wet granulation technique using a guar gum polymer in different ratios. These granules filled into the formaldehyde treated capsules and plugged with optimized HPMC plug, to maintain the...
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Posted by admin on Oct 1, 2012 in |
The present work aim was “Formulation Strategy for Dissolution Enhancement of Simvastatin”. Simvastatin is lipid lowering drug which is known as HMG CoA reductase. The objective of this study was to increase the solubility of poorly water soluble drug, namely simvastatin, by the formation of solid dispersion and complex and also using the microwave induction technique on these formations. For solid dispersion method dispersion carrier used were poloxamer 407 and gelucire 44/14. The fusion method was used to prepare the dispersions. For inclusion complexation method β-cyclodextrin derivative of cyclodextrin was used to prepare complex with drug. Kneading method was used for formulation. After completion of these two techniques these polymers were used for the microwave induced fusion method. All the ratio of drug and polymer were used to heat for different time interval. These samples were used for solubility measurement. In the solid dispersion technique, simvastatin show higher increase in solubility with gelucire 44/14 in the ratio of 1:5 as compare to poloxamer 407. In the microwave induced fusion...
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Posted by admin on Oct 1, 2012 in |
In the present work for the simultaneous estimation of Metolazone (METO) and Spironolactone (SPI) Ratio Derivative Spectrophotometric method have been developed. In this method the overlapping spectra of Metolazone and Spironolactone were well resolved by making use of the first-derivative of the ratios of their direct absorption spectra. Methanol:water (1:4) was used as solvent for the method. Amplitude at 241.0nm and 263.0 nm were selected in the ratio derivative spectra to determine METO and SPI, respectively. Beer’s law was obeyed in the concentration ranges of 1-5μg/mL and 5-25 μg/ mL METO and SPI, respectively in the method. The % assay for commercial formulation was found to be in the range 98.00% – 102.00 % for METO and 99.00% – 102.60 % for SPI by the proposed method. Recovery was found in the range of 99.74 – 100.76 % for METO and SPI in the Formulations. The results of analysis have been validated statistically and recovery studies confirmed the accuracy and reproducibility of the proposed methods which were carried out...
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